Evaluation of Histological and non-Invasive Methods for the Detection of Liver Fibrosis: The Values of Histological and Digital Morphometric Analysis, Liver Stiffness Measurement and APRI Score

Abstract

Prognosis and treatment of liver diseases mainly depend on the precise evaluation of the fibrosis. Comparisons were made between the results of Metavir fibrosis scores and digital morphometric analyses (DMA), liver stiffness (LS) values and aminotransferase-platelet ratio (APRI) scores, respectively. Liver biopsy specimens stained with Sirius red and analysed by morphometry, LS and APRI measurements were taken from 96 patients with chronic liver diseases (56 cases of viral hepatitis, 22 cases of autoimmune- and 18 of mixed origin). The strongest correlation was observed between Metavir score and DMA (r = 0.75 p < 0.05), followed in decreasing order by LS and Metavir (r = 0.61), LS and DMA (r = 0.47) LS and APRI (r = 0.35) and Metavir and APRI (r = 0.24), respectively. DMA is a helpful additional tool for the histopathological evaluation of fibrosis, even when the sample size is small and especially in case of advanced fibrosis. The non-invasive methods showed good correlation with the histopathological methods; LS proved to be more accurate than APRI. The stronger correlation between LS values and Metavir scores, as well as the results of DMA in case of appropriate sample size were remarkable.

Construction and analysis for differentially expressed long non-coding RNAs and MicroRNAs mediated competing endogenous RNA network in colon cancer

“…In addition, research reported that up-regulation of lncRNA H19 significantly promotes epithelial to mesenchymal transition (EMT) progression and accelerates colorectal cancer cell growth by competing binding the miR-138 and miR-200a to modulate the derepression of targeted genes Vimentin, ZEB1, and ZEB2[ 24 ]. Peng et al found lncRNA ROR can mediate the expression of miR-145 and participated in proliferation, migration and invasion of colon cancer cell[ 25 ]. Recent studies have revealed that the lncRNA PART-1 was up-regulated in colorectal cancer, functioned as a competitive endogenous RNA to regulate the targeted gene DNMT3A by sponging miR-143, participated in colorectal cancer cell proliferation and metastasis[ 26 ].…”

Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients

“…The invasive nature of this test and the potential risks associated have driven the search of a noninvasive method for diagnosis and follow up of IFALD. The APRI has been validated to grade liver fibrosis in adult patients with chronic viral hepatitis 12 – 16 …”

Ultrasound findings in autoimmune hepatitis

“…TE proved also to be more accurate than APRI score in study published by Halasz et al[ 71 ] including 22 cases of AIH.…”