Evaluation of Hereditary Risk in a Mammography Population

Jones, Julie L.; Hughes, Kevin S.; Kopans, Daniel B.; Moore, Richard H.; Howard-McNatt, Marissa; Hughes, Sherwood S.; Lee, Nancy Y.; Roche, Constance A.; Siegel, Nancy; Gadd, Michele A.; Smith, Barbara L.; Michaelson, James

doi:10.3816/cbc.2005.n.007

Cited by 21 publications

(16 citation statements)

References 17 publications

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“…A number of studies have reported that patients of all races/ethnicities, geographical areas, and socioeconomic status are able and willing to enter certain data using a computer, and that these data are reliable [13][14][15][16][17][18]. In addition, several studies have shown that screening for hereditary risk of cancer using family history is feasible in both a primary care setting and in women presenting for screening mammography [19][20][21].…”

Section: Discussionmentioning

confidence: 99%

Screen positive rates among six family history screening protocols for breast/ovarian cancer in four cohorts of women

et al. 2008

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It has been estimated that approximately 2% of the general population has a family history that is indicative of hereditary breast/ovarian cancer. We aim to further document the proportions of women identified by several protocols as having a positive family history of breast/ovarian cancer, as a prelude to offering genetic counseling and BRCA1/2 mutation testing. This is a critical component of the evidence base needed when considering implementation of family history screening in primary care. We apply six separate family history screening protocols for breast/ovarian cancer to four cohorts of women, 21 to 55 years of age, for whom self-reported personal, and first and second degree family histories of breast/ovarian cancer have been obtained. We analyzed family history for 3,073 women in the four cohorts. The screen positive rates among the protocols vary widely both within and among the cohorts. In Cohort 4, the screen positive rate ranges between 6.9% to 20.8%, depending on the protocol. Applying one of the protocols to the four cohorts yields screen positive rates between 5.0% and 16.7%. The proportion of women that is screen positive on all six protocols (or three, if Ashkenazi Jewish) ranges from 1.9% to 4.0%. Used alone, none of the recommended family history protocols yields an acceptable screen positive rate. A more acceptable 2% to 4% screen positive rate can be expected when all six protocols agree.

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Section: Discussionmentioning

confidence: 99%

Screen positive rates among six family history screening protocols for breast/ovarian cancer in four cohorts of women

et al. 2008

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“…A UK study estimated that in an average general practice of 2,000 patients, 30–40 patients aged 35–64 years would have a first-degree relative with one of four common cancers [15]. Other studies have estimated a similar prevalence of cancer and at risk family members [16,17,18,19]. While not all patients with only one relative with cancer would be eligible for referral, it seems likely that Ontario family physicians are making too few referrals.…”

Section: Discussionmentioning

confidence: 99%

Genetic Services for Hereditary Breast/Ovarian and Colorectal Cancers – Physicians’ Awareness, Use and Satisfaction

Carroll

Cappelli²,

Miller³

et al. 2008

Public Health Genomics

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Objectives: In 2000, the Ministry of Health in Ontario, Canada, introduced a publicly funded program to provide genetic services for hereditary breast/ovarian and colorectal cancers. We surveyed physicians to determine their awareness, use and satisfaction with this program. Methods: A self-administered questionnaire was mailed to a random sample of 25% of Ontario family physicians and all gynecologists, oncologists (radiation, surgical and medical), gastroenterologists and general surgeons. Results: Response rate was 49% (n = 1,427). Awareness of genetic testing for breast/ovarian cancer was high (91%) but less for colorectal cancer (60%). Use of services was associated with physician age of 40 or greater, urban location, confidence in knowledge of referral criteria and core competencies in genetics, and awareness of the program and where to refer. Almost half were dissatisfied with notification about the program. Conclusions: Ontario physicians are aware of cancer genetics services, and use is associated with increased knowledge of services, and confidence in skills. They would like more timely services and education about hereditary cancers and susceptibility testing.

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“…A challenge remains in applying our awareness of current and evolving knowledge of hereditary risk to a broad population in a practical way, given the variation in hereditary risk models. 24 Family history information can have value apart from just risk assessment. A patient's breast cancer screening behavior and beliefs about the benefits of such early detection practices seem to be influenced by not only presence or absence of a family history of cancer, but other dimensions of family history as well.…”

Section: Breast Cancer Family History Effectsmentioning

confidence: 99%

The impact of family history of breast cancer and cancer death on women's mammography practices and beliefs

Tracy¹,

Quillin²,

Wilson³

et al. 2008

Genetics in Medicine

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Evaluation of Hereditary Risk in a Mammography Population

Cited by 21 publications

References 17 publications

Screen positive rates among six family history screening protocols for breast/ovarian cancer in four cohorts of women

Screen positive rates among six family history screening protocols for breast/ovarian cancer in four cohorts of women

Genetic Services for Hereditary Breast/Ovarian and Colorectal Cancers – Physicians’ Awareness, Use and Satisfaction

The impact of family history of breast cancer and cancer death on women's mammography practices and beliefs

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