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Raphinus sativus Linn (Cruciferae) commonly known as 'Radish' is a multipurpose herb cultivated in different parts of the world for its edible roots and leaves. The present study was aimed to evaluate the antiulcer activity of leaf extracts of R. sativus Linn on acetic acid induced chronic gastric ulcer and pylorus ligation induced gastric ulcer in rats. The acute oral toxicity study revealed that all the extracts were safe up to 2000 mg/kg per oral dose; hence one-tenth of this dose was selected for evaluation of antiulcer activity. In acetic acid induced gastric ulcer models, the ERS, CRS, EARS and AQRS have offered significant protection against acetic acid induced ulcers when compared to control group. While in pylorus ligation induced ulcer model the ERS, EARS and AQRS showed significant protection by decreasing the ulcer index, total acidity and free acidity. In conclusion the leaf extracts of R. sativus Linn are found to possess antiulcer property in the experimental animal models of gastric ulcers, which is consistent with the literature report in the folk medicine.
Raphinus sativus Linn (Cruciferae) commonly known as 'Radish' is a multipurpose herb cultivated in different parts of the world for its edible roots and leaves. The present study was aimed to evaluate the antiulcer activity of leaf extracts of R. sativus Linn on acetic acid induced chronic gastric ulcer and pylorus ligation induced gastric ulcer in rats. The acute oral toxicity study revealed that all the extracts were safe up to 2000 mg/kg per oral dose; hence one-tenth of this dose was selected for evaluation of antiulcer activity. In acetic acid induced gastric ulcer models, the ERS, CRS, EARS and AQRS have offered significant protection against acetic acid induced ulcers when compared to control group. While in pylorus ligation induced ulcer model the ERS, EARS and AQRS showed significant protection by decreasing the ulcer index, total acidity and free acidity. In conclusion the leaf extracts of R. sativus Linn are found to possess antiulcer property in the experimental animal models of gastric ulcers, which is consistent with the literature report in the folk medicine.
Background: Colon cancer is a major health problem worldwide and rated among as one of the top frequent cancers and is a major cause of morbidity and mortality. Treatment outcome is still not satisfactory and other treatment options are strongly needed. Carbohydrate protein interactions play a major role in numerous biological processes including cancer. However, the seeds of Raphanus sativus have never been tested for its anticancer effects on colon cancer. Therefore, this study aimed at elucidating the anti-carcinogenic effect of Raphanus sativus in combating chemically (DMH) induced colon cancer. Materials and methods: polysaccharides extract of Raphanus sativus (RS) was tested for its ability to reverse the carcinogenic effects of 1, 2 dimethylhydrazine (DMH) which is used for chemical induction of colon cancer in animal models. Rats were injected with DMH and the effects of RS extract either concomitant with or after the administration of DMH were evaluated.. We measured the serum Carcinoembryonic antigen and Carbohydrate antigen as a tumor markers, Glutathione reducatse and Glutathione S transferase as markers of antioxidant activity and liver functions. Results: RS significantly reduced Serum CEA (P<0.01) and CA19-9 (P<0.01) as an evidence of its anticarcinogenic effect in colon cancer. Moreover, RS was able to significantly increase activity of Glutathione reductase (p<0.01) and Glutathione-S-transferase (p<0.01) as a measure of antioxidant compared with DMH untreated group. Also RS was able to significantly increase activities of ALAT, ASAT and ALP (p<0.01). Chemical analysis of RS done by NMR and paper chromatography revealed that the polysaccharide in RS was -galactan and the type of bond that exists between sugar residues is 1, 3 and 1, 6 glucosidic linkages. Conclusions: This study shows that -galactan of Raphanus sativus has pronounced cytotoxic effects on colon cancer cell line. Moreover, it reduces serum tumor markers and enhancing antioxidant activity in the DMH injected animals. This polysaccharide might be a suitable candidate as a chemopreventive and as an adjuvant therapy for colon cancer.
In the present study crude powder and various extracts of Teucrium stocksianum were evaluated for anti-diabetic effect in alloxan-induced diabetic rabbits. Crude extract significantly reduced blood glucose level of normal and diabetic rabbits. The results were comparable with standard drug glibenclamide. Ethyl acetate extract (500 mg/kg) produced maximum decrease in blood glucose level among all the extracts and was selected for further study. Ethyl acetate extract significantly inhibited rise in glucose level in normal rabbits after an oral glucose load. The extract showed synergistic effect with different doses of insulin. Serum insulin level of diabetic rabbits was also significantly increased by the extract. HbA1c level was significantly (p<0.05) reduced whereas hemoglobin level was significantly increased by the extract. It is concluded that ethyl acetate extract may be a good remedy to manage diabetes and its complications. Article Info
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