Evaluation of Hepatoprotective and Oxidative Stress Reducing Activities of Garlic And/or Ginger Against Cisplatin-induced Liver Toxicity in Rats.

Abstract

Cisplatin is an anticancer drug with high efficiency against various types of tumors including head and neck, bladder, ovarian, lung, and testicular cancers. However, its use is limited due to its toxicity to various tissues including hepatotoxicity. Seven groups (n=10) of rats were used. Group I received normal saline, group II received garlic (200 mg/kg) and group III received ginger (310 mg/kg body weight) orally once per day for 21 consecutive days. Group IV received saline plus cisplatin on the 16 th day (10 mg/kg, intraperitoneal). Group V received garlic plus cisplatin on the 16 th day. Group VI received ginger plus cisplatin on 16 th day and group VII received garlic and ginger plus cisplatin on 16 th day. Cisplatin induced a significant (P<0.05) increase in hepatic serum biomarkers including AST, ALT, and ALP levels and a significant (P<0.05) decrease in ALB level. Moreover, cisplatin induced a significant (P<0.05) increase in MDA level and caused a significant (P<0.05) depletion in CAT, GSH and SOD levels in liver tissues. Furthermore, cisplatin induced severe histopathological alteration in liver tissue. Garlic and ginger have hepatoprotective and antioxidant activities, which may be beneficial for protecting against liver damage.