Evaluation of hepatoprotective and antioxidant activity of &lt;i&gt;Ichnocarpus frutescens&lt;/i&gt; (Linn.) R.Br. on paracetamol-induced hepatotoxicity in rats

Dash, Deepak Kumar; Yeligar, Veerendra C.; Nayak, Siva S.; Ghosh, Tapas; Rajalingam, D.; Sengupta, Pinaki; Maiti, B. R.; Maity, Tapan K.

doi:10.4314/tjpr.v6i3.14656

Cited by 104 publications

(82 citation statements)

References 20 publications

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“…Lipid peroxidation has been postulated to the destructive process of liver injury due to cadmium administration. The increase in MDA levels in liver suggests enhanced lipid peroxidation leading to tissue damage and failure of antioxidant defense mechanisms to prevent formation of excessive free radicals [32]. Group III and Group IV rats administered with low and high doses of Ocimum sanctum extract showed a significant (P \ 0.01) decrease in the liver LPO levels when compared to Group II rats.…”

Section: Studies On Antioxidant Enzymesmentioning

confidence: 95%

Antioxidant Activities of Hydroalcoholic Extract of Ocimum sanctum Against Cadmium Induced Toxicity in Rats

Ramesh

Satakopan

2010

Indian J Clin Biochem

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The present study was undertaken to analyze the antioxidant (both enzymic and nonenzymic) activities of leaves of Ocimum sanctum hydroalcoholic extract against cadmium induced damage in albino rats. Oral administration of cadmium as CdCl 2 (6.0 mg/kg body weight) led to significant elevation of lipid peroxidation (LPO) levels and significantly decreased Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx), Reduced Glutathione (GSH) and Vitamin C (Ascorbate) levels. Administration of Ocimum sanctum extract (100 mg/kg body weight, po) and (200 mg/kg body weight, po) before and after cadmium intoxication showed a significant decrease in LPO levels and significant increase in SOD, CAT, GPx, GSH and Ascorbate levels. The results suggest that oral administration of Ocimum sanctum extract provides significant protection against cadmium induced toxicity in Wistar albino rats.

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Section: Studies On Antioxidant Enzymesmentioning

confidence: 95%

Antioxidant Activities of Hydroalcoholic Extract of Ocimum sanctum Against Cadmium Induced Toxicity in Rats

Ramesh

Satakopan

2010

Indian J Clin Biochem

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“…CAT, hemeprotein, catalyzes the reduction of hydrogen peroxides 29 , acts as preventive antioxidant and plays an important role in protection against the deleterious effects of lipid peroxidation 30 .The activity levels of catalase in tissue decreased in CCl 4 treated animals might be due to the inhibition of CAT activity, which is suggestive to enhanced synthesis of O 2 -is a powerful inhibitor of catalase 31 .…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and antioxidant effect of Polygala chinensis L. whole plant against CCl4 induced hepatotoxicity in rats

Mohan¹,

Sakthidevi²

2013

Int J of Biomed & Adv Res

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“…Recently, it has been suggested that certain physiological disorders attributed to this heavy metal are directly or indirectly related to the generation of reactive oxygen species (ROS) that leads to a condition termed as oxidative stress [2,14,20]. Plant extracts and phytoconstituents have been found to be effective as radical scavengers and inhibitors of lipid peroxidation [10]. It has been hypothesized that usage of an antioxidant agent in the presence of a chelator would increase the efficacy of intoxication treatment with lead [12].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

Al-Otaibi¹,

Virk²,

Elobeid³

2015

Acta Biologica Hungarica

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The present study investigates the protective efficacy of stem bromelain against lead-induced toxicity in male Wistar rats. There were six experimental groups; Group I was negative control, Group II was administered only 20 mg/kg of stem bromelain. Group III and V were orally exposed to 30 mg/kg/day and 60 mg/kg/day of lead acetate, respectively. Group IV and Group VI were exposed to both low and high dose of lead acetate, respectively, and treated with 20 mg/kg stem bromelain. The experimental period was 21 days. The end points evaluated were, lead accumulation in kidney, liver and spleen, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity, serum malonaldehyde (MDA) cholesterol and triglycerides levels. Co-administration of stem bromelain with lead markedly reduced the lead accumulation in the kidney and spleen. The treatment of stem bromelain also reduced the serum MDA levels in the group exposed to lower dose of lead and serum triglyceride level in the group exposed to higher dose of lead. The lead-induced modulated levels of serum ALT and AST were also alleviated by bromelain treatment. Our key findings suggest a chelating potential of stem bromelain for combating lead toxicity and oxidative stress. Bromelain represents a novel approach to the treatment of metal toxicity and metabolic disorders with a limited therapeutic window.

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Evaluation of hepatoprotective and antioxidant activity of <i>Ichnocarpus frutescens</i> (Linn.) R.Br. on paracetamol-induced hepatotoxicity in rats

Cited by 104 publications

References 20 publications

Antioxidant Activities of Hydroalcoholic Extract of Ocimum sanctum Against Cadmium Induced Toxicity in Rats

Antioxidant Activities of Hydroalcoholic Extract of Ocimum sanctum Against Cadmium Induced Toxicity in Rats

Hepatoprotective and antioxidant effect of Polygala chinensis L. whole plant against CCl4 induced hepatotoxicity in rats

Ameliorative potential of stem bromelain on lead-induced toxicity in Wistar rats

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