Evaluation of hepatitis B and hepatitis C virus-infected renal allograft recipients with liver biopsy and noninvasive parameters

Fehr, Thomas; Riehle, Hans-Martin; Nigg, Luzia; Grüter, Erwin; Ammann, Peter; Renner, Eberhard L.; Ambühl, Patrice M.

doi:10.1016/s0272-6386(03)00423-2

Cited by 27 publications

(14 citation statements)

References 32 publications

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“…It has been suggested that <10% of HCV-infected patients develop advanced liver fibrosis even 10 years after infection [4,47]. In our study, only 2 patients (11%) developed advanced liver fibrosis/cirrhosis.…”

Section: Hepatitis C Virus Infection Is a Common And Important Diseascontrasting

confidence: 50%

Lack of Impact of Hepatitis C Virus Infection on Graft Survival After Kidney Transplantation—A Portuguese Single-Center Experience

Magalhães-Costa

Lebre

Machado³

et al. 2015

Transplantation Proceedings

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Section: Hepatitis C Virus Infection Is a Common And Important Diseascontrasting

confidence: 50%

Lack of Impact of Hepatitis C Virus Infection on Graft Survival After Kidney Transplantation—A Portuguese Single-Center Experience

Magalhães-Costa

Lebre

Machado³

et al. 2015

Transplantation Proceedings

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“…In a previous survey in Iran, HCV RNA was detected in 6.4% of liver transplant recipients (26). Moreover, the infection in renal transplant recipients varies between 2.6% and 66% in different geographical areas of the world (27)(28)(29).…”

Section: Discussionmentioning

confidence: 96%

Hepatitis C Virus Load in Seropositive Liver and Kidney Transplant Recipients by Quantitative Real-Time PCR Before and After Transplantation

Behzadi

Ziyaeyan

2013

Jundishapur J Microbiol

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Background: Hepatitis C virus (HCV) infection is one the major health concern among the infected transplant patients. Considering several complications of the disease in them, pre and post-transplantation studies should be performed for monitoring of the infection, as well as, developing new treatment protocols. Objectives: The current study was conducted to determine the Hepatitis C Virus RNA level among seropositive liver and kidney transplant recipients in Namazi Hospital; the main transplantation center in southern Iran. Materials and Methods: RNAs were extracted from 105 serum samples of seropositive liver and kidney transplant recipients and analyzed by Real-time PCR assay using a set of primers. Results: HCV RNA was detected in a total of 46/105 (43.8%) recipients' serum samples [39/46 (84.8%) males and 7/46 (15.2%) females]. Moreover, 8/46 (17.4%) and 38/46 (82.6%) were kidney and liver recipients, respectively. The copy number of HCV RNA, measured by the Real-time PCR assay, ranged from 5 × 102 to 3.14 × 109 copies/mL; Median 2.37 × 105 copies/mL and 1.7 × 103 to 9.44 × 104 copies/mL; Median 2.89 × 104 copies/ mL in liver and renal transplant patients, respectively. The comparison of viral load between liver pre transplant recipients group and post transplant counterpart indicated that the copy number of HCV RNA was significantly higher in the post transplant recipients (P = 0.033). The prevalence of the viral nucleic acid was significantly higher in males than in females (P = 0.026). Similarly, with regards to the age groups, the prevalence of HCV RNA was significantly higher in age group ≥ 45 years than age group < 45 years (P = 0.028). Conclusions: Considering the results, it can be concluded that HCV RNA detection is strongly suggested in transplant patients group to determine the prevalence of the disease and their responses to antiviral therapy and diagnosis of drug resistance. In addition, continuous and regular surveillance of HCV RNA level in such patients is highly recommended in order to better manage the complications of graft loss and reduce the mortality rate. Further studies are needed to find new therapeutic methods to lower the incidence of infection of new healthy allograft tissues in HCV RNA positive recipients.

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“…Although BUN and serum creatinine levels alter as liver fibrosis progresses, and could be defined as indirect markers, they have not been used as noninvasive markers of liver fibrosis [23]. In a cross-sectional study of 900 renal allograft recipients, no correlation was observed between the eGFR and histologic activity of liver disease [24]. Therefore, FibroTest that includes assessment of eGFR may not be superior to FibroTest without eGFR, even though serum creatinine level is an independent predictor of survival in cirrhotic patients.…”

Section: Discussionmentioning

confidence: 99%

Renal Function in Patients with Liver Cirrhosis

Chen

Chang³

et al. 2010

Nephron Clin Pract

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Background: Despite the poor prognosis of patients with both cirrhosis and renal failure, most reports on renal function and outcomes of cirrhosis have come from liver transplant registries. The present study aimed to investigate the association between renal function and cirrhosis in a broader population. Methods: 3,857 patients were enrolled after the exclusion of patients with incomplete data. The most recent demographic data after the latest laboratory measurements obtained at outpatient or inpatient department were collected. Results: In predicting renal function, estimated glomerular filtration rate (eGFR) was found to be dissociated from Child-Pugh points (β = –0.01, p = 0.691), different causes of cirrhosis, and presence of diabetes (β = –0.03, p = 0.112). In terms of predicting in-hospital mortality, the sensitivity (60–82%) and specificity (70–90%) of the model for end-stage liver disease (MELD) score increased with the decrease in eGFR. However, the blood urea nitrogen (BUN)/creatinine ratio was better than the MELD score in patients with normal eGFR. Conclusion: In contrast to prerenal causes of kidney injury, the underlying causes of cirrhosis or diabetes had relatively minor effects on renal function in cirrhotic patients. The BUN/creatinine ratio was a better index than the MELD score in predicting in-hospital mortality in cirrhotic patients with normal renal function.

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Evaluation of hepatitis B and hepatitis C virus-infected renal allograft recipients with liver biopsy and noninvasive parameters

Cited by 27 publications

References 32 publications

Lack of Impact of Hepatitis C Virus Infection on Graft Survival After Kidney Transplantation—A Portuguese Single-Center Experience

Lack of Impact of Hepatitis C Virus Infection on Graft Survival After Kidney Transplantation—A Portuguese Single-Center Experience

Hepatitis C Virus Load in Seropositive Liver and Kidney Transplant Recipients by Quantitative Real-Time PCR Before and After Transplantation

Renal Function in Patients with Liver Cirrhosis

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