Evaluation of Hematological Parameters of Helicobacter pylori-Infected Adult Patients at Southern Ethiopia: A Comparative Cross-Sectional Study

Abstract

Background Helicobacter pylori ( H. pylori ) infection is a global public health problem, a higher burden of the infection was reported in developing countries including Ethiopia. It has been associated with several gastrointestinal diseases, and recently implicated in some hematological abnormalities. Despite the high prevalence of H. pylori infection in Ethiopia, there was limited data regarding the relationship between hematological parameters with H. pylori infection. Therefore, this study aimed to evaluate selected hematological parameters of H. pylori -infected patients attending Wachemo University Nigist Eleni Mohammed Memorial Referral Hospital (WUNEMMRH), Hosanna, Southern, Ethiopia. Methods and Materials A comparative cross-sectional study was conducted from January to May 2019 among 374 (187 H. pylori -infected patients and 187controls) study participants. Data on socio-demographic characteristics were collected using a structured questionnaire. A five-milliliter venous blood sample was collected for hematological parameter analysis. Approximately two gram of stool specimen was collected to assess the presence of H. pylori antigen. Data were entered and analyzed by using SPSS version 21. Pearson correlation analysis and independent sample T-test was performed, and P-value < 0.05 was considered statistically significant. Results Mean value of Hgb (p<0.001), RBC count (p<0.001), HCT (p<0.001), MCV (p=0.003), MCH (p=0.008), and MCHC (p=0.006) of H. pylori -infected patients were significantly lower than control group. However, the mean value of RDW (p=0.003) in H. pylori -infected patients was significantly higher than in the control group. About 13.3%, 7%, 6.4%, and 18.2% of H. pylori -infected patients showed reduced Hgb concentration, RBC count, HCT, and MCV values, respectively. Conclusion The study showed a statistically significant difference in the mean value of Hgb, RBC count, HCT, MCV, MCH, MCHC, and RDW of H. pylori -infected patients and controls. Thus, hematological parameters should be considered for proper diagnosis and management of H. pylori -infected patients and eradication of this microorganism from infected patients, determination of hematological parameters for H. pylori -infected patients were recommended.

Impact of Helicobacter pylori-Related Metabolic Syndrome Parameters on Arterial Hypertension

“…Likewise, Helicobacter pylori (H. pylori) infection is a global public health problem [34], with higher burdens in the developing nations [34,35], mostly owing to low socio-economic levels, and the potential drinking of contaminated water. H. pylori infection is very common with a mean global prevalence of 58%, partly due to immigrants coming from countries with a high prevalence of H. pylori infection [36].…”

Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults

“…Such triggers may include but are not limited to certain infections that may be conducive to anemia of inflammation and elevated RDW (e.g. H. pylori infection) (Haile and Timerga, 2021). In fact, H. pylori infection is more prevalent and can lead to atrophic gastritis to a greater extent among men than among women (Ferro et al, 2019) and was shown recently to be associated with incident AD mostly among men (Beydoun et al, 2018).…”

Acute Helicobacter pylori infection prevalence and association with metabolic abnormality in general Chinese population: A retrospective study

“…Helicobacter pylori (H pylori ) infection was a global public health problem, with higher burdens in the developing countries. [ 1 , 2 ] Nevertheless, epidemiological researches in China yielded inconsistent conclusion. [ 3 ] At the same time, the prevalence of H pylori infection in China might be diverse among different ethnics and different regions.…”