Evaluation of height-dependent and height-independent methods of estimating baseline serum creatinine in critically ill children

Abstract

Height-dependent and height-independent bSCr estimation methods were comparable. This may have significant implications for performing pediatric AKI research using large databases, and in clinical care to define AKI when height is unknown.

Factors that influenced undergoing renal replacement therapy and survival in children with acute kidney injury

“…Overall mortality rate was 26.9%, but of the 59 dead patients, 11 died after recovery from AKI. Median time for mortality was 8 days (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Overall patient survival rates were 83.6% for 10 days and 47.3% for 28 days.…”

“…Pottel et al has shown before that their height independent formula has a good correlation with the Schwartz formula. Very recently, Hessey et al showed that height independent formulas are comparable with the height dependent formulas in estimating GFR in children with AKI . We have calculated a baseline creatinine concentration for patients who had no serum creatinine concentration 3 months prior to AKI.…”

“…Very recently, Hessey et al showed that height independent formulas are comparable with the height dependent formulas in estimating GFR in children with AKI. 17 We have calculated a baseline creatinine concentration for patients who had no serum creatinine concentration 3 months prior to AKI. These patients had mostly no underlying disease and thus had normal creatinine concentrations.…”

Healthcare Utilization after Acute Kidney Injury in the Pediatric Intensive Care Unit

“…Index hospitalization data were collected by retrospective chart review (described previously) (14). Before final analysis, independent reviewers from each center reassessed 50 randomly selected charts to evaluate and correct for sources of reduced reliability (92% of continuous variables had inter-rater correlation $0.90 and 96% of categoric variables had $90% agreement).…”

Big Data and Pediatric Acute Kidney Injury: The Promise of Electronic Health Record Systems

“…A final option for patients without a known baseline, is to apply an age-based normative creatinine value. In this scenario, a population-based serum creatinine is assigned to each patient based on their demographic characteristics (23,24). Each of these potential solutions have been validated and, ultimately, the approach applied should reflect the goals of the diagnostic tool.…”