Evaluation of Heart Rate Variability and Endothelial Function 3 Months After Bariatric Surgery

Braga, Tassia Gomide; Souza, Maria das Graças Coelho de; Maranhão, Priscila Alves; Menezes, Michel; Dellatorre‐Teixeira, Ludmilla; Roux, Carel W. le; Kraemer‐Aguiar, Luiz Guilherme

doi:10.1007/s11695-020-04397-4

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Several hypotheses have been put forward trying to explain individually variable improvement, and one of the issues studied is the role of the ANS function in this process [ 13 , 23 ]. However, these mechanisms are extremely complex and still not fully understood [ 2 , 7 , 11 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…The effects of weight loss following various techniques of bariatric surgery on hyperinsulinemia, insulin resistance and obesity associated neuropathy are still of interest. Available data suggest that various techniques of bariatric surgery improve metabolic control, including glycemic homeostasis and increased insulin sensitivity [ 5 , 6 , 7 , 8 , 9 ]. However, limited recent results are available on assessment of the dynamics of fasting glucose, insulin levels, insulin resistance/sensitivity indices and also ANS indices in patients with class III obesity, who lost weight due to laparoscopic sleeve gastrectomy (LSG), especially at a relatively young age and without severe accompanying diseases.…”

Section: Introductionmentioning

confidence: 99%

“…However, limited recent results are available on assessment of the dynamics of fasting glucose, insulin levels, insulin resistance/sensitivity indices and also ANS indices in patients with class III obesity, who lost weight due to laparoscopic sleeve gastrectomy (LSG), especially at a relatively young age and without severe accompanying diseases. The available data often provide inconclusive and contradictory results too [ 7 , 10 , 11 , 12 , 13 ]. There is also no detailed evaluation of the impact of weight loss following bariatric surgery on the occurrence of various arrhythmias [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Holter-Derived Autonomic Function, Arrhythmias and Carbohydrate Metabolism in Patients with Class III Obesity Treated with Laparoscopic Sleeve Gastrectomy

Bienias

Rymarczyk

Domienik‐Karłowicz

et al. 2021

JCM

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The effects of weight loss following bariatric surgery on autonomic balance, arrhythmias and insulin resistance are still of interest. We prospectively investigated 50 patients with BMI > 40 kg/m2, aged 36.5 (18–56) years who underwent laparoscopic sleeve gastrectomy. Among other examinations, all subjects had 24-h Holter monitoring with heart rate variability (HRV) and heart rate turbulence (HRT) evaluation. After a median of 15 months, BMI decreased from 43.9 to 29.7 kg/m2, the incidence of hypertension decreased from 54 to 32% (p = 0.04) and any carbohydrate disorders decreased from 24 to 6% (p = 0.02). Fasting insulin concentration and insulin resistance index improved significantly (p < 0.001). Improvements in HRV parameters related to the sympathetic autonomic division were also observed (p < 0.001), while HRT evaluation was not conclusive. The enhancement of autonomic tone indices was correlated with reduction of BMI (SDNN-I r = 0.281 p = 0.04; SDNN r = 0.267 p = 0.05), but not with reduction of waist circumference, and it was also associated with decrease of mean heart rate (OR 0.02, 95%CI 0.0–0.1, p < 0.001). The incidence of arrhythmias was low and similar before and after follow-up. In conclusion, improvement of homeostasis of carbohydrate metabolism and autonomic function is observed in relatively young patients after weight loss due to laparoscopic sleeve gastrectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Holter-Derived Autonomic Function, Arrhythmias and Carbohydrate Metabolism in Patients with Class III Obesity Treated with Laparoscopic Sleeve Gastrectomy

Bienias

Rymarczyk

Domienik‐Karłowicz

et al. 2021

JCM

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“…Regardless of the surgical procedure used, studies have shown that in the postoperative period, mainly due to the loss of visceral fat and changes in intestinal peptides, there is a significant improvement in metabolic parameters: lipid profile, glycemic control, reduction of insulin resistance, MAFLD (metabolic associated fatty liver disease), inflammation, sleep apnea, or stricter blood pressure control [ 113 , 114 , 115 , 116 , 117 , 118 , 119 ]. These benefits were assessed in both shorter and longer follow-up periods, which allowed us to observe that some of them are transient.…”

Section: Obesity Treatmentmentioning

confidence: 99%

Clinical and Therapeutic Implications of Male Obesity

Lenart-Lipińska,

Łuniewski,

Szydełko

et al. 2023

JCM

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The prevalence of obesity, a disorder linked to numerous comorbidities and metabolic complications, has recently increased dramatically worldwide and is highly prevalent in men, even at a young age. Compared to female patients, men with obesity more frequently have delayed diagnosis, higher severity of obesity, increased mortality rate, and only a minority of obese male patients are successfully treated, including with bariatric surgery. The aim of this review was to present the current state of knowledge about the clinical and therapeutic implications of obesity diagnosed in males.

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“…Although previous studies have demonstrated low HRV in obesity and sarcopenia [ 4 , 5 , 6 , 7 ] and that bariatric surgery (BS) reduced blood pressure (BP) and cardiac autonomic dysfunction in patients with obesity [ 14 , 15 , 16 , 17 ], there are no data in the literature evaluating the impact of BS on cardiac autonomic modulation in individuals with parameters related to sarcopenia. Considering the probable loss of muscle mass after BS [ 18 ] and that irisin, a myokine that acts in neurons in the nucleus as ambiguous promoting bradycardia, is produced by skeletal muscle, it is reasonable to infer that the benefits of BS on the cardiac autonomic system might be attenuated in individuals with low muscle mass and strength.…”

Section: Introductionmentioning

confidence: 99%

Effects of Preoperative Sarcopenia-Related Parameters on Cardiac Autonomic Function in Women with Obesity Following Bariatric Surgery: A One-Year Prospective Study

et al. 2023

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Objectives: Investigate changes in blood pressure (BP) and heart rate variability (HRV) in women with and without sarcopenia-related parameters who underwent bariatric surgery (BS) during a one-year follow-up. Subjects and Methods: Women were separated into obesity (OB, n = 20) and women with obesity displaying sarcopenia-related parameters (SOP, n = 14) and evaluated before BS and 3, 6, and 12 months after BS. SOP was defined as low handgrip strength (HS) and/or low appendicular skeletal mass adjusted for weight (ASM/wt × 100, %) in the lowest quartile of the sample. ASM/wt × 100, % and HS were significantly lower in SOP than OB over a one-year follow-up of BS (p < 0.05). Results: There was a reduction in diastolic BP, heart rate (HR), SDHR, LF, and the LF/HF ratio (p < 0.05) and an increase in the HF band in both groups during the follow-up period (p < 0.05). SOP women had reduced root mean square differences of successive RR intervals (RMSSD) and HF band and an increased LF band and SD2/SD1 ratio compared to the OB group during the one-year follow-up (p < 0.05). ASM/wt × 100, % was negatively associated with the LF band (r = −0.24, p = 0.00) and positively associated with the HF band (r = 0.22, p = 0.01). Conversely, HS had no association with LF (r = −0.14, p = 0.09) and HF (r = 0.11, p = 0.19). ASM/wt × 100, % and HS were negatively associated with the LF/HF ratio (p < 0.05). Conclusions: Women who underwent BS had an improved HRV over a one-year follow-up. However, the improvement in HRV variables was less pronounced in women with low muscle mass and/or HS during the follow-up period.

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Evaluation of Heart Rate Variability and Endothelial Function 3 Months After Bariatric Surgery

Cited by 6 publications

References 10 publications

Holter-Derived Autonomic Function, Arrhythmias and Carbohydrate Metabolism in Patients with Class III Obesity Treated with Laparoscopic Sleeve Gastrectomy

Holter-Derived Autonomic Function, Arrhythmias and Carbohydrate Metabolism in Patients with Class III Obesity Treated with Laparoscopic Sleeve Gastrectomy

Clinical and Therapeutic Implications of Male Obesity

Effects of Preoperative Sarcopenia-Related Parameters on Cardiac Autonomic Function in Women with Obesity Following Bariatric Surgery: A One-Year Prospective Study

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