Evaluation of Health-related Quality of Life for Hypothesized Medical States Associated with Cervical Cancer

Murasawa, Hideki; Konno, Ryo; Okubo, Ichiro; Arakawa, Ichiro

doi:10.7314/apjcp.2014.15.22.9679

Cited by 9 publications

(13 citation statements)

References 14 publications

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“…The mean (SD) EQ-5D utility scores of cancer stage I, II, III, and IV in this study were 0.85 (0.19), 0.76 (0.20), 0.71 (0.21), and 0.77 (0.13), respectively. The mean (SD) EQ-5D utility scores by cancer stage in Japanese sample were 0.80 (0.15), 0.78 (0.11), 0.64 (0.15), 0.63 (0.15), 0.71 (0.15), 0.50 (0.17), 0.52 (0.17), 0.21 (0.28) for cancer stage IA1, IA2, IB1, IB2, IIA, IIB, III, and IV, respectively (Murasawa et al, 2014). The utility scores of Indonesian sample were higher as compared to Japanese sample.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies had been conducted to evaluate the quality of life of patients with cervical cancer in many settings using either the specific instruments (Goker et al, 2011;Azmawati et al, 2014) or generic instruments (Lang et al, 2010;Murasawa et al, 2014) and presenting the report as either a health profile in the format of score of each dimension of patient health status (Lang et al, 2010;Goker et al, 2011;Azmawati et al, 2014) or utility scores (Lang et al, 2010;Murasawa et al, 2014). Utility can be converted from EQ-5D health states using a countryspecific scoring algorithm and value sets.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia

Endarti

Riewpaiboon²,

Thavorncharoensap³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Evaluation of health-related quality of life (HRQOL) in cervical cancer patients is important in order to design the interventions for improving patient outcomes. Reports of HRQOL among cervical cancer patients in Indonesia are limited. Moreover, measurement using EQ-5D-3L is to our best knowledge has hitherto not been performed. This study aimed to examine the HRQOL of cervical cancer patients in Indonesia using EQ-5D-3L. Materials and Methods: A cross-sectional study was conducted by interviewing cervical cancer patients using the EQ-5D-3L questionnaire. Percentages of patients who reported having problems in each dimension of EQ-5D as well as EQ-5D index score (utility) were calculated. Results: Our findings indicated that the most frequent reported problems were pain/discomfort (67.8%) followed by anxiety/depression (57.5%). The mean of EQ-5D VAS was 75.8 (SD=17.0). The mean (SD) utility scores were 0.85 (0.19), 0.76 (0.20), 0.71 (0.21), and 0.77 (0.13) for cervical cancer patients in stage I, II, III, and IV, respectively. Conclusions: Cervical cancer significantly affects patient HRQOL. Efforts should be made to improve the quality of life of cervical cancer patients especially in terms of pain /discomfort and anxiety/depression reduction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia

Endarti

Riewpaiboon²,

Thavorncharoensap³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…When Endarti et al [46] examined patients with cervical cancer, disutilities based on EQ-5D-3L were greatest for stage IV vs stage I (− 0.080) compared with [30]: EQ-5D-3L, own health state, patients and healthy controls. c Murasawa [47]: SG, hypothetical health states, general population (female students). d Endarti [46]: EQ-5D-3L, own health state, patients.…”

Section: Cervical Cancermentioning

confidence: 99%

“…b Hildebrandt[30]: EQ-5D-3L, own health state, patients and healthy controls. c Murasawa[47]: SG, hypothetical…”

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confidence: 99%

Health state utility values by cancer stage: a systematic literature review

Pourrahmat¹,

Kim

Kansal

et al. 2021

Eur J Health Econ

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Objectives Cancer diagnoses at later stages are associated with a decrease in health-related quality of life (HRQOL). Health state utility values (HSUVs) reflect preference-based HRQOL and can vary based on cancer type, stage, treatment, and disease progression. Detecting and treating cancer at earlier stages may lead to improved HRQOL, which is important for value assessments. We describe published HSUVs by cancer type and stage. Methods A systematic review was conducted using Embase, MEDLINE®, EconLit, and gray literature to identify studies published from January 1999 to September 2019 that reported HSUVs by cancer type and stage. Disutility values were calculated from differences in reported HSUVs across cancer stages. Results From 13,872 publications, 27 were eligible for evidence synthesis. The most frequent cancer types were breast (n = 9), lung (n = 5), colorectal (n = 4), and cervical cancer (n = 3). Mean HSUVs decreased with increased cancer stage, with consistently lower values seen in stage IV or later-stage cancer across studies (e.g., − 0.74, − 0.44, and − 0.51 for breast, colorectal, and cervical cancer, respectively). Disutility values were highest between later-stage (metastatic or stage IV) cancers compared to earlier-stage (localized or stage I–III) cancers. Conclusions This study provides a summary of HSUVs across different cancer types and stages that can inform economic evaluations. Despite the large variation in HSUVs overall, a consistent decline in HSUVs can be seen in the later stages, including stage IV. These findings indicate substantial impairment on individuals’ quality of life and suggest value in early detection and intervention.

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“…Hal ini sejalan dengan hasil penelitian di Jepang. 26 Demikian pula dengan hasil penelitian di Malaysia yang menunjukkan bahwa kualitas hidup pasien makin menurun seiring dengan makin parahnya kanker serviks yang diderita. 27 Pasien stadium I yang telah menjalani kemoterapi, diperoleh data nilai indeks kondisi kesehatan pasien (utility) meningkat secara bermakna.…”

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Quality of Life Evaluation of Cervical Cancer Inpatients Before and After Chemotherapy by Using the EQ-5D Questionnaire

Suwendar

Fudholi

Andayani

et al. 2017

Indones J Clin Pharm

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AbstrakKualitas hidup merupakan salah satu acuan keberhasilan dari upaya pengobatan termasuk kemoterapi pada pasien kanker. Pasien kanker yang menjalani kemoterapi dapat mengalami perubahan pada kualitas hidupnya. Tujuan penelitian ini adalah untuk menilai kualitas hidup pasien kanker serviks dengan menggunakan kuesioner EQ-5D sebelum dan setelah mendapatkan kemoterapi. Penelitian ini merupakan penelitian non-eksperimental bersifat analitik menurut perspektif pasien dengan teknik pengumpulan data secara prospektif. Subjek penelitian adalah pasien kanker serviks rawat inap kelas 3 yang memenuhi kriteria inklusi. Penelitian dilakukan di RSUP Dr. Hasan Sadikin Bandung. Data yang digunakan adalah data pasien dari bulan Juni sampai Desember 2015. Penelitian dilakukan dengan menggunakan kuesioner EQ-5D. Selanjutnya dilakukan perhitungan persentase permasalahan pasien, nilai indeks EQ-5D (utility) dan nilai EQ-5D VAS. Nilai utility dan EQ-5D VAS dianalisis secara statistik dengan uji Wilcoxon (α=5%) untuk melihat terjadinya perubahan kondisi yang bermakna sebelum dan setelah kemoterapi. Hasil menunjukkan bahwa setelah kemoterapi siklus pertama, persentase masalah kemampuan berjalan/bergerak dan kegiatan yang biasa dilakukan mengalami peningkatan, rasa sakit/ tidak nyaman dan rasa cemas/depresi mengalami penurunan, sedangkan perawatan diri tidak mengalami perubahan. Berdasarkan hasil uji statistik, setelah kemoterapi siklus pertama, nilai utility dan EQ-5D VAS mengalami peningkatan dan menunjukkan peningkatan bermakna (nilai T hitung masing-masing 2,0 dan 4,5) pada pasien stadium I.Kata kunci: Kanker serviks, kemoterapi, kualitas hidup, kuesioner EQ-5D Quality of Life Evaluation of Cervical Cancer Inpatients Before and After Chemotherapy by Using the EQ-5D Questionnaire AbstractThe quality of life is one of success parameters of the treatment effort including chemotherapy in cancer patients. Cancer patients undergoing chemotherapy may experience changes in their quality of life. This study aimed to assess the quality of life of patients with cervical cancer in Indonesia using the EQ-5D questionnaire pre and post-chemotherapy. The research was an analitycal non-experimental study according to the patient's perspective using prospective data collection techniques. The research subjects were the patients who suffered from cervical cancer who were hospitalized in class 3 and fullfilled the inclusive requirement. The research was conducted in Dr. Hasan Sadikin Bandung general hospital, from June until December 2015. The study was conducted by the EQ-5D questionnaire. Futhermore, the percentage of the patients' problems, EQ-5D index (utility) and EQ-5D VAS were calculated. Utility and EQ-5D values was analysed statistically using Wilcoxon test (α=5%) to determine if there were significant condition changes before and after chemotherapy. The results showed that after the first cycle of chemotherapy, the percentage of patients reporting problem is related to ability to walk/move and the usual activities problem increased, pain/...

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Evaluation of Health-related Quality of Life for Hypothesized Medical States Associated with Cervical Cancer

Cited by 9 publications

References 14 publications

Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia

Evaluation of Health-Related Quality of Life among Patients with Cervical Cancer in Indonesia

Health state utility values by cancer stage: a systematic literature review

Quality of Life Evaluation of Cervical Cancer Inpatients Before and After Chemotherapy by Using the EQ-5D Questionnaire

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