Evaluation of Haematological Parameters of Obese Individuals Based on Age Groups at Omisanjana Area of Ado Ekiti, Ekiti State

Obeagu, Emmanuel Ifeanyi; Rashid, Huba Khamis; Okafor, Chukwuma J.; Omotunde, Precious

doi:10.9734/jpri/2022/v34i12a35546

Cited by 10 publications

(13 citation statements)

References 8 publications

(9 reference statements)

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“…Managing obstetric hemorrhage effectively often necessitates prompt and targeted interventions, with blood transfusions playing a pivotal role in stabilizing the patient and preventing severe complications. [15][16][17][18][19][20][21][22][23] Postpartum hemorrhage resulting from uterine atony, a failure of the uterus to contract effectively after childbirth, is one of the most common causes of excessive bleeding. Transfusions are often…”

Section: Indications For Blood Transfusions During Pregnancy Obstetri...mentioning

confidence: 99%

“…Addressing these challenges effectively requires comprehensive strategies, and blood transfusions emerge as indispensable lifesaving interventions. [7][8][9][10][11][12] The administration of blood and blood products has revolutionized obstetric care, providing a crucial lifeline in managing acute blood loss, correcting anemia, and mitigating complications during pregnancy and childbirth. While the primary focus of blood transfusions is to stabilize maternal conditions, their impact extends to ensuring the optimal growth and development of the fetus.1 [3][4][5][6][7][8][9][10][11][12][13][14] This paper aims to provide a comprehensive overview of the importance of blood transfusions during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review

Obeagu,

Obeagu

2024

Asian J Dental Health Sci

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Pregnancy is a remarkable yet complex physiological state that can be accompanied by various complications, including obstetric hemorrhage and severe anemia, which significantly affect maternal and fetal health. Blood transfusions serve as crucial interventions to manage these complications and mitigate potential risks. This comprehensive review synthesizes the pivotal role of blood transfusions during pregnancy, encompassing their indications, benefits, risks, and advancements in transfusion medicine. Exploring the multifaceted landscape of transfusions in addressing obstetric challenges, anemia, and other maternal conditions, this article underscores the paramount importance of timely and appropriate transfusion interventions to safeguard the health and well-being of both mother and child. Through an in-depth analysis of current knowledge and emerging trends, this review aims to provide a holistic understanding of the significance of blood transfusions in optimizing outcomes during pregnancy. Keywords: Blood Transfusions, Pregnancy, Maternal Health, Hemorrhage, Anemia, Obstetrics, Fetal Health, Transfusion Medicine

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Section: Indications For Blood Transfusions During Pregnancy Obstetri...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review

Obeagu,

Obeagu

2024

Asian J Dental Health Sci

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“…Obstetric hemorrhage, often unforeseen and rapid in onset, poses substantial risks to both maternal and fetal health, necessitating immediate and effective interventions (2). Transfusion therapy, encompassing the administration of blood and blood products, serves as a cornerstone in stabilizing maternal hemodynamics, restoring adequate oxygenation, and addressing coagulopathies during obstetric emergencies (3)(4)(5)(6)(7). Transfusion therapy in obstetrics encompasses a multifaceted approach involving the timely and judicious utilization of blood components to address acute maternal bleeding, which frequently arises from complications such as postpartum hemorrhage, placental abruption, uterine atony, or surgical procedures.…”

Section: Introductionmentioning

confidence: 99%

Understanding Transfusion Therapy in Obstetrics: Ensuring Maternal and Fetal Health

E.I.,

G.U,

P.M.

2023

KJHS

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Transfusion therapy plays a pivotal role in obstetrics, serving as a critical intervention to address various maternal and fetal health challenges. The review encompasses the indications, types, and implications of transfusion therapy, aiming to provide a thorough understanding of its role in ensuring optimal outcomes for both mother and fetus. Obstetric hemorrhage remains a leading cause of maternal morbidity and mortality globally. Transfusion therapy, involving the administration of blood and blood products, emerges as a cornerstone in the management of obstetric hemorrhage, offering a lifeline in critical situations. This abstract delves into the specific scenarios, such as postpartum hemorrhage and placental abruption, where timely transfusions are essential to prevent severe complications. Anemia, a prevalent concern in pregnancy, necessitates a nuanced approach to transfusion therapy. Understanding the thresholds for transfusion in the context of pregnancy-related anemia is crucial for balancing the benefits against potential risks. This review discusses the challenges in managing anemia, exploring the role of transfusion in alleviating symptoms and optimizing maternal and fetal health. In conclusion, this paper synthesizes the current knowledge on transfusion therapy in obstetrics, emphasizing its pivotal role in managing obstetric hemorrhage, anemia, and blood disorders. By elucidating the intricacies of transfusion therapy and its implications for maternal and fetal health, this review aims to guide healthcare professionals in making informed decisions, ultimately contributing to enhanced obstetric care and improved outcomes for pregnant individuals and their infants.

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“…Additionally, we explore the regulatory mechanisms governing neutrophil activation, the release of inflammatory mediators, and the potential utility of biomarkers associated with heightened inflammation as predictive tools for adverse pregnancy outcomes. The significance of comprehending the impact of neutrophil-derived inflammation on pregnancy outcomes extends to clinical practice, necessitating a deeper understanding to inform obstetric care, prenatal monitoring, and therapeutic interventions [11][12][13]. Ultimately, uncovering the nuanced role of neutrophil-driven inflammation during gestation holds promise for deciphering pathways to optimize maternal-fetal health and offers avenues for future research to bridge knowledge gaps in this critical realm of perinatal immunology.…”

Section: Introductionmentioning

confidence: 99%

“…Neutrophil Functions and Inflammatory Responses Neutrophils, as essential components of the innate immune system, play a pivotal role in mounting inflammatory responses to combat infections and maintain tissue homeostasis [14][15][16]. Neutrophils are rapidly mobilized to sites of infection or tissue injury through a process called chemotaxis [17].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-Derived Inflammation and Pregnancy Outcomes

Obeagu,

Igwe

et al. 2023

NIJSES

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Inflammation, orchestrated by immune cells like neutrophils, plays a crucial role in maintaining homeostasis and protecting against pathogens. However, during pregnancy, the delicate balance of immune responses is paramount to support fetal development while safeguarding maternal health. Neutrophils, as pivotal contributors to the innate immune system, significantly influence the inflammatory milieu, yet excessive or dysregulated neutrophil-derived inflammation can impact pregnancy outcomes. This paper aims to dissect the multifaceted role of neutrophil-derived inflammation in shaping pregnancy outcomes. It delves into the mechanisms by which neutrophils orchestrate inflammatory responses during gestation and scrutinizes the implications of heightened inflammation on maternalfetal health. Specifically, it explores the association between increased neutrophil-driven inflammation and adverse outcomes such as preterm birth, preeclampsia, intrauterine growth restriction, and fetal developmental abnormalities. Examining the intricate balance between protective and detrimental roles of neutrophil-derived inflammation, this review assesses alterations in neutrophil functions, activation pathways, and the release of inflammatory mediators during normal and pathological pregnancies. Additionally, it evaluates potential regulatory mechanisms governing neutrophil-derived inflammation and identifies putative biomarkers indicative of heightened inflammatory responses linked to adverse pregnancy outcomes. The clinical implications of understanding the impact of neutrophil-derived inflammation on pregnancy outcomes are highlighted, emphasizing its significance in obstetric care, prenatal monitoring, and potential therapeutic interventions. Furthermore, this review delineates the NEWPORT INTERNATIONAL JOURNAL OF SCIENTIFIC AND EXPERIMENTAL SCIENCES (NIJSES) Volume 4 Issue 2 2023 ©NIJSES Publications Open Access ONLINE ISSN: 2992-5819 PRINT ISSN: 2992-6149 Obeagu et al., 2023 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Page | 11 critical need for future research avenues focusing on molecular investigations, therapeutic modulation of neutrophildriven inflammation, and longitudinal studies to elucidate the long-term consequences on maternal and fetal wellbeing. In conclusion, unraveling the intricate interplay between neutrophil-derived inflammation and pregnancy outcomes is imperative. A deeper understanding of these interactions holds promise for informing clinical strategies, improving prenatal care, and ultimately optimizing maternal and fetal health.

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Evaluation of Haematological Parameters of Obese Individuals Based on Age Groups at Omisanjana Area of Ado Ekiti, Ekiti State

Cited by 10 publications

References 8 publications

The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review

The Vital Role of Blood Transfusions during Pregnancy: A Comprehensive Review

Understanding Transfusion Therapy in Obstetrics: Ensuring Maternal and Fetal Health

Neutrophil-Derived Inflammation and Pregnancy Outcomes

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