Evaluation of Guar Gum in the Preparation of Sustained-Release Matrix Tablets

Khullar, Praveen; Khar, Roop K.; Agarwal, Shivam

doi:10.3109/03639049809089955

Cited by 80 publications

(41 citation statements)

References 4 publications

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“…Binder, disintegrant, thickening agent, emulsifier, laxative, sustained release agent [47,48,49] 12 Gum acacia Acacia arabica Leguminoseae Suspending agent, emulsifying agent, binder in tablets, demulcent and emollient in cosmetics [50] 13 Gum ghatti Anogeissus latifolia Combretaceae Binder, emulsifier, suspending agent [51] 14 …”

Section: Disadvantages Of Natural Gums and Mucilagesmentioning

confidence: 99%

Natural Gums, Mucilage’s and Their Applications in Novel Drug Delivery Systems – A Comprehensive Review

Muthukumaran¹

2017

WJPPS

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Active ingredient and excipients are two main ingredients of any pharmaceutical formulation. Excipients help in the manufacturing of dosage form as well as improve physicochemical parameters of the dosage form. Polymers play a vital role in any dosage form as excipients. The influencing capacity of polymers towards the drug release and should be compatible, non-toxic and stable and economic etc. Nowadays, due to many problems associated with drug release and side effects of synthetic polymers manufacturers are inclined towards using natural polymers. Natural polymers being polysaccharides are biocompatible and without any side effects. This article is intended to provide an overview of various types of naturally occurring polymers, applications, isolations and characterizations which has been considered for the delivery of conventional and novel dosage forms.

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Section: Disadvantages Of Natural Gums and Mucilagesmentioning

confidence: 99%

Natural Gums, Mucilage’s and Their Applications in Novel Drug Delivery Systems – A Comprehensive Review

Muthukumaran¹

2017

WJPPS

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“…Tamarind gum was extracted from the kernel by a method described by Khullar et al, (1998), in three batches at laboratory scale. To 20 grams of tamarind kernel powder, 200 ml of cold distilled water was added and slurry was prepared.…”

Section: Polysaccharide Extractionmentioning

confidence: 99%

Optimizing Roasting Standards for Quality Gum Production in Tamarind Seed Gum Production

Nagajothi¹,

Balasubramanian²,

Renganayaki³

et al. 2017

Int.J.Curr.Microbiol.App.Sci

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“…Naturally occurring polymers are increasingly becoming the focus of research on hydrophilic matrices for oral controlled release (Naggar et al, 1992;Bonferoni et al, 1993;Kristmundsdo´ttir et al, 1995;Sujja-areevath et al, 1996;Talukdar et al, 1996;Khullar et al, 1998;Vervoort et al, 1998;Nep 2015). They hydrate and swell on contact with water forming the gel layer controlling drug release from the tablet matrices.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of sesamum gum as an excipient in matrix tablets

Nep

Asare-Addo²,

Ngwuluka

et al. 2016

British Journal of Pharmacy

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In developing countries modern medicines are often beyond the affordability of the majority of the population. This is due to the reliance on expensive imported raw materials despite the abundance of natural resources which could provide an equivalent or even an improved function. The aim of this study was to investigate the potential of sesamum gum (SG) extracted from the leaves of Sesamum radiatum (readily cultivated in sub-Saharan Africa) as a matrix former. Directly compressed matrix tablets were prepared from the extract and compared with similar matrices of HPMC (K4M) using theophylline as a model water soluble drug. The compaction, swelling, erosion and drug release from the matrices were studied in deionized water, 0.1 N HCl (pH 1.2) and phosphate buffer (pH 6.8) using USP apparatus II. The data from the swelling, erosion and drug release studies were also fitted into the respective mathematical models. Results showed that the matrices underwent a combination of swelling and erosion, with the swelling action being controlled by the rate of hydration in the medium. SG also controlled the release of theophylline similar to the HPMC and therefore may have use as an alternative excipient in regions where Sesamum radiatum can be easily cultivated.

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Evaluation of Guar Gum in the Preparation of Sustained-Release Matrix Tablets

Cited by 80 publications

References 4 publications

Natural Gums, Mucilage’s and Their Applications in Novel Drug Delivery Systems – A Comprehensive Review

Natural Gums, Mucilage’s and Their Applications in Novel Drug Delivery Systems – A Comprehensive Review

Optimizing Roasting Standards for Quality Gum Production in Tamarind Seed Gum Production

Evaluation of sesamum gum as an excipient in matrix tablets

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