Evaluation of group vaccination of sows and gilts against Salmonella Typhimurium with an attenuated vaccine in subclinically infected pig herds

Peeters, Linda; Dewulf, Jeroen; Boyen, Filip; Brossé, C.; Vandersmissen, Tamara; Rasschaert, Geertrui; Heyndrickx, Marc; Cargnel, Mickaël; Mattheus, Wesley; Pasmans, Frank; Haesebrouck, Freddy; Maes, Dominiek

doi:10.1016/j.prevetmed.2020.104884

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Using dexamethasone administration to mimic preslaughter stress and induce Salmonella recrudescence, Leyman et al (134) demonstrated reduced Salmonella loads in intestinal contents and tissues from vaccinated pigs compared to nonvaccinated pigs. Evaluation of the Salmoporc vaccine in various stages of pig production (sows, piglets, fattening pigs, sows and piglets, sows and fattening pigs) revealed a decrease in the prevalence of S. Typhimurium field strain-positive lymph nodes at slaughter (131) but did not significantly decrease Salmonella shedding in the herd (129). The authors observed elevated concentrations of maternally derived antibodies in 3-day-old piglets from vaccinated sows but also determined that high antibody levels in vaccinated piglets and fattening pigs interfered with serology-based Salmonella monitoring programs in slaughter pigs, demonstrating a need for DIVA (differentiating infected from vaccinated animals) vaccines (130).…”

Section: Vaccination As An Intervention Against Salmonella In Swinementioning

confidence: 96%

“…Although not licensed by CVB, the Salmoporc vaccine is available in the European Union, and several studies have shown its effectiveness at reducing Salmonella in pigs (118,(129)(130)(131)(132)(133). Using dexamethasone administration to mimic preslaughter stress and induce Salmonella recrudescence, Leyman et al (134) demonstrated reduced Salmonella loads in intestinal contents and tissues from vaccinated pigs compared to nonvaccinated pigs.…”

Section: Vaccination As An Intervention Against Salmonella In Swinementioning

confidence: 99%

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Salmonellain Swine: Prevalence, Multidrug Resistance, and Vaccination Strategies

Bearson

2022

Annu. Rev. Anim. Biosci.

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An estimated 1.3 million Salmonella infections and 420 deaths occur annually in the United States, with an estimated economic burden of $3.7 billion. More than 50% of US swine operations test positive for Salmonella according to the National Animal Health Monitoring System, and 20% of Salmonella from swine are multidrug resistant (resistant to ≥3 antimicrobial classes) as reported by the National Antimicrobial Resistance Monitoring System. This review on Salmonella in swine addresses the current status of these topics by discussing antimicrobial resistance and metal tolerance in Salmonella and the contribution of horizontal gene transfer. A major challenge in controlling Salmonella is that Salmonella is a foodborne pathogen in humans but is often a commensal in food animals and thereby establishes an asymptomatic reservoir state in such animals, including swine. As food animal production systems continue to expand and antimicrobial usage becomes more limited, the need for Salmonella interventions has intensified. A promising mitigation strategy is vaccination against Salmonella in swine to limit animal, environmental, and food contamination. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 10 is February 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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Section: Vaccination As An Intervention Against Salmonella In Swinementioning

confidence: 96%

Section: Vaccination As An Intervention Against Salmonella In Swinementioning

confidence: 99%

Salmonellain Swine: Prevalence, Multidrug Resistance, and Vaccination Strategies

Bearson

2022

Annu. Rev. Anim. Biosci.

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“…Current S.Tm vaccinations have some efficacy in disease prevention and variable efficacy in reduction of shedding, but they do not decolonize the herd. Correspondingly, it remains impossible to completely exclude Salmonella from a farm with known carriage, without culling all animals [6][7][8][9][10]. In a model mimicking pre-slaughter stress, fecal shedding was not different between pigs vaccinated with the licensed Salmoporc vaccine and unvaccinated animals [3].…”

Section: Introductionmentioning

confidence: 99%

A rationally designed inactivatedSalmonellaTyphimurium vaccine induces strong and long-lasting immune responses in pigs

Lentsch

Aslani

Echtermann

et al. 2023

Preprint

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Salmonella enterica subspecies enterica serovar Typhimurium (S.Tm) poses a considerable threat to public health due to its zoonotic potential. Human infections are mostly foodborne, and pork and pork products are ranked among the top culprits for transmission. In addition, the high percentage of antibiotic resistance, especially in monophasic S.Tm, limits treatment options when needed. Better S.Tm control would therefore be of benefit both for farm animals and for safety of the human food chain. A promising pre-harvest intervention is vaccination. In this study we tested safety and immunogenicity of an oral inactivated S.Tm vaccine, which has been recently shown to generate an evolutionary trap and to massively reduce S.Tm colonization and transmission in mice. We show that this vaccine is highly immunogenic and safe in post-weaning pigs and that administration of a single oral dose results in a strong and long-lasting serum IgG response. This has several advantages over existing - mainly live - vaccines against S.Tm, both in improved seroconversion and reduced risk of vaccine-strain persistence and reversion to virulence.

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“…Londrina, v. 44, n. 6, p. 2079-2094, nov./dez. 2023 studies evaluating Salmonella vaccination have variable results (Costa et al, 2020;Cruz et al, 2017;Gil et al, 2020;Peeters et al, 2019Peeters et al, , 2020Schwarz et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Efficiency evaluation of a novel orally administered subunit vaccine to reduce the prevalence of Salmonella enterica in swine under field conditions

Reichen,

Coldebella,

Dezen

et al. 2023

Sem. Ci. Agr.

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Salmonella enterica can be carried by pigs and can reach the final product and the consumer. Thus, Salmonella reduction strategies along the swine production chain should be studied. In this sense, the objective of the study was to evaluate a subunit vaccine based on secondary antigens administered orally against natural infection in swine farms in Brazil. A field trial study was conducted to estimate the effect of the vaccination on the Salmonella spp. seroprevalence, presence in lymph nodes, and fecal content in commercial pig herds in a vertical integration system belonging to an agroindustry. Furthermore, nMPN, qPCR, and phagocytic activity were performed. There were no significant differences in seroprevalence between groups. The mMPN count of Salmonella spp. in feces was higher in vaccinated group (VG), ranging from 0 to 2.46 log mMPN/g, while in control group (CG) it ranged from 0.0 to 4 log mMPN/g, showing a significant group effect (p<0.05), being confirmed in the qPCR. The activity of phagocytic monocytes was not altered by vaccination on farms. Thus, the oral subunit vaccination strategy at this stage of development did not reduce the spread and amplification of the infection in farms that would impact the prevalence of pigs carrying and shedding Salmonella spp. until slaughter.

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Evaluation of group vaccination of sows and gilts against Salmonella Typhimurium with an attenuated vaccine in subclinically infected pig herds

Cited by 5 publications

References 41 publications

Salmonellain Swine: Prevalence, Multidrug Resistance, and Vaccination Strategies

Salmonellain Swine: Prevalence, Multidrug Resistance, and Vaccination Strategies

A rationally designed inactivatedSalmonellaTyphimurium vaccine induces strong and long-lasting immune responses in pigs

Efficiency evaluation of a novel orally administered subunit vaccine to reduce the prevalence of Salmonella enterica in swine under field conditions

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