Evaluation of GLUT1, IGF-2, VEGF, FGF 1, and angiopoietin 2 in infantile hemangioma

Köker, Sultan Aydın; Kömüroğlu, Ahmet Ufuk; Köksoy, Adem Yasin; Şiraz, Ülkü Gül; Tekin, Emine; Köker, Alper

doi:10.1016/j.arcped.2021.02.009

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…It has been detected to be highly expressed during the proliferating phase of IH, but the underlying mechanism is unclear ( Yu et al, 2004 ). The same results can be found in Muller’s experiments that the serum levels of GLUT1, IGF-2, and VEGF-A in IH were significantly higher than those in healthy control ( Aydin Köker et al, 2021 ). IGF2 can stimulate multiple steps of endothelial progenitor cells (EPC) homing in vitro and promote both EPC recruitment and incorporation into the neovascular area, resulting in enhanced angiogenesis ( Maeng et al, 2009 ).…”

Section: Discussionsupporting

confidence: 83%

Transcriptional data analysis reveals the association between infantile hemangiomas and venous malformations

Huang

Zhang²,

Zhong³

et al. 2022

Front. Genet.

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Background: Infantile hemangiomas (IH) and venous malformations (VM) are the most common types of vascular abnormalities that seriously affect the health of children. Although there is evidence that these two diseases share some common genetic changes, the underlying mechanisms need to be further studied.Methods: The microarray datasets of IH (GSE127487) and VM (GSE7190) were downloaded from GEO database. Extensive bioinformatics methods were used to investigate the common differentially expressed genes (DEGs) of IH and VM, and to estimate their Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Trough the constructing of protein-protein interaction (PPI) network, gene models and hub genes were obtained by using Cytoscape and STRING. Finally, we analyzed the co-expression and the TF-mRNA-microRNA regulatory network of hub genes.Results: A total of 144 common DEGs were identified between IH and VM. Functional analysis indicated their important role in cell growth, regulation of vasculature development and regulation of angiogenesis. Five hub genes (CTNNB1, IL6, CD34, IGF2, MAPK11) and two microRNA (has-miR-141-3p, has-miR-150-5p) were significantly differentially expressed between IH and normal control (p < 0.05).Conclusion: In conclusion, our study investigated the common DEGs and molecular mechanism in IH and VM. Identified hub genes and signaling pathways can regulate both diseases simultaneously. This study provides insight into the crosstalk of IH and VM and obtains several biomarkers relevant to the diagnosis and pathophysiology of vascular abnormalities.

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Section: Discussionsupporting

confidence: 83%

Transcriptional data analysis reveals the association between infantile hemangiomas and venous malformations

Huang

Zhang²,

Zhong³

et al. 2022

Front. Genet.

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“…The mechanism that regulates the proliferation and migration of vascular endothelial cells is complex and involves the regulation of multiple cytokines. In previous studies, VEGF, basic fibroblast growth factor (bFGF), glucose transporter 1 and MMP were found to be closely associated with proliferation of hemangiomas ( 21-23 ). There are numerous methods to detect the expression of these factors in patients with infantile hemangiomas, e.g., by urine, serum, or hemangioma tissue.…”

Section: Discussionmentioning

confidence: 97%

Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma

Pan

Huang²,

Xiao-pin

et al. 2022

Mol Clin Oncol

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Infantile hemangioma is a common benign tumor in infants. However, the molecular mechanism that controls the proliferation and differentiation of hemangioma is not well understood. Annexin A1 (ANX A1) is a phospholipid-binding protein involved in a variety of biological processes, including inflammation, cell proliferation and apoptosis. To explore the significance of ANX A1 in the process of proliferation or differentiation of hemangioma, proliferating and involuting hemangioma tissues were collected to detect the expression of ANX A1 using immunohistochemistry and western blotting. Normal skin tissues were used as the negative control. The results revealed that ANX A1 was upregulated in the proliferative phase of hemangioma, and its expression was decreased when the hemangioma entered the involuting phase. Additionally, in the proliferative phase, the strongest staining of ANX A1 was observed in newly born capillaries, and the staining of ANX A1 became weaker in enlarged vessels, indicating that ANX A1 plays an important role in promoting the formation of capillaries. The expression of hypoxia-inducible factor (HIF)-1α was positively associated with the expression trend of ANX A1, suggesting that the overexpression of ANX A1 may be associated with the increase of HIF-1α. In summary, the results of the present study revealed that the expression of ANX A1 was increased in proliferating hemangioma tissue, and that high expression of ANX A1 may be closely associated with the formation of capillaries in infantile hemangioma.

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“…The VEGF signaling pathway is involved in the pathogenesis of IHs and regulates angiogenesis. Propranolol can cause vasoconstriction, tumor growth inhibition, angiogenesis inhibition, and induce apoptosis ( 21 ). Makkeyah et al.…”

Section: Discussionmentioning

confidence: 99%

Low-dose sclerotherapy with lauromacrogol in the treatment of infantile hemangiomas: A retrospective analysis of 368 cases

Wang

Sun²,

Guo³

et al. 2022

Front. Oncol.

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BackgroundIntralesional injection of lauromacrogol has proven to be an efficient treatment method for infantile hemangioma. This study aims to explore a novel injection therapy and evaluate its efficacy and complications.MethodsThe medical records of 368 children with infantile hemangioma who received a lauromacrogol injection from January 2021 to April 2022 were retrospectively analyzed. All patients were reviewed every 4 weeks, and their condition was assessed according to symptoms and medical records. The patient’s age, lesion type, location, size and thickness, lesion photographs, ultrasound, and complications were recorded.ResultsAmong the 368 infants who accept sclerotherapy with lauromacrogol, 226(61.4%)achieved excellent regression. In total, 108(29.4%)cases achieved good regression. 24(6.5%)achieved complete moderate regression. 10(2.7%)achieved poor regression. The reported incidence of adverse events was 4.9% and severe complications were not observed. Before and after three courses of treatment, the median vascular endothelial growth factor levels were 104.12 pg/ml and 28.982 pg/ml. There was a significant difference between the two groups (P=0.0043).ConclusionsThe results showed that this novel injection therapy a safe and effective treatment method. The therapy accelerated the regression of infantile hemangiomas without serious complications.

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Evaluation of GLUT1, IGF-2, VEGF, FGF 1, and angiopoietin 2 in infantile hemangioma

Cited by 5 publications

References 30 publications

Transcriptional data analysis reveals the association between infantile hemangiomas and venous malformations

Transcriptional data analysis reveals the association between infantile hemangiomas and venous malformations

Overexpression of Annexin A1 is associated with the formation of capillaries in infantile hemangioma

Low-dose sclerotherapy with lauromacrogol in the treatment of infantile hemangiomas: A retrospective analysis of 368 cases

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