Evaluation of Glucose Tolerance, Post-Prandial Hyperglycemia and Hyperinsulinemia Influencing the Incidence of Coronary Heart Disease

Yamasa, Toshihiko; Ikeda, Satoshi; Koga, Seiji; Kawahara, Eisuke; Muroya, Takahiro; Shinboku, Hiroki; Kohno, Shigeru

doi:10.2169/internalmedicine.46.6231

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…The serum values were non-fasting. However, non-fasting triglyceride values are found to influence cardiovascular and all-cause mortality [23], and postprandial glucose values seem to influence the risk of coronary heart disease [24]. We do not consider that these factors will distort cross-sectional associations.…”

Section: Strengths and Limitationsmentioning

confidence: 88%

Risk factors for cardiovascular diseases and diabetes in disability pensioners aged 40—42 years: A cross-sectional study in Norway

Hewitt

Graff-Iversen

2009

Scand J Public Health

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Section: Strengths and Limitationsmentioning

confidence: 88%

Risk factors for cardiovascular diseases and diabetes in disability pensioners aged 40—42 years: A cross-sectional study in Norway

Hewitt

Graff-Iversen

2009

Scand J Public Health

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“…On the other hand, postprandial plasma glucose was generally considered as an important risk factor for macro-vascular complications. Postprandial plasma glucose was proven to be associated with CVD events not only in cross-sectional studies 8 , 18 but also in cohort studies. 19 Meanwhile, postprandial plasma glucose was found to be related to CKD in an earlier study.…”

Section: Discussionmentioning

confidence: 99%

Association of different glucose traits with kidney function decline risk in a Chinese community-based population without chronic kidney disease

Wang

Fan

Jia

et al. 2018

TCRM

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BackgroundChronic kidney disease (CKD) has become a major issue worldwide and hyperglycemia is known as an important risk factor responsible for CKD progression. Few studies have investigated whether fasting plasma glucose (FPG) could predict kidney function decline (KFD) risk better than postprandial plasma glucose, and vice versa. In this study, we investigated the roles of FPG and 2-hour plasma glucose (2 h-PG) in predicting KFD risk in a Chinese community-based population without baseline deterioration of kidney functions.MethodsSubjects with normal kidney function from an atherosclerosis cohort in Beijing, China were followed up for 2.3 years. The outcome was KFD (a drop in glomerular filtration rate category accompanied by 25% or greater decline of estimated glomerular filtration rate from the baseline or a sustained decline of more than 5 mL/min/1.73 m2/year rate).ResultsA total of 3,738 subjects were included of which, 7.7% of the subjects suffered from KFD. After covariates adjustments, both FPG (OR =1.23, P<0.001) and 2 h-PG (OR =1.07, P<0.001) were associated with KFD. Furthermore, FPG was independent of 2 h-PG to predict KFD (OR =1.26, P<0.001). Subgroup analyses and interaction tests including diabetes mellitus, after adjusting all covariates, revealed no significant heterogeneity among analyzed subgroups. We also found subjects with FPG level of 6.1–7.0 mmol/L and >7.0 mmol/L had 1.83 times and 2.51 times KFD risk respectively, compared to subjects with FPG level <5.6 mmol/L.ConclusionFPG was superior to 2 h-PG in predicting KFD in a Chinese community-based population without CKD. FPG screening may be an important measure for CKD primary prevention even in subjects with impaired fasting glucose.

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Impact of diabetic serum on endothelial cells: An in-vitro-analysis of endothelial dysfunction in diabetes mellitus type 2

Münzel

Lehle

Haubner

et al. 2007

Biochemical and Biophysical Research Communications

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Evaluation of Glucose Tolerance, Post-Prandial Hyperglycemia and Hyperinsulinemia Influencing the Incidence of Coronary Heart Disease

Abstract: Background Recently, the frequency of patients who have glucose intolerance has been increasing in Japan

Cited by 5 publications

References 12 publications

Risk factors for cardiovascular diseases and diabetes in disability pensioners aged 40—42 years: A cross-sectional study in Norway

Risk factors for cardiovascular diseases and diabetes in disability pensioners aged 40—42 years: A cross-sectional study in Norway

Association of different glucose traits with kidney function decline risk in a Chinese community-based population without chronic kidney disease

Impact of diabetic serum on endothelial cells: An in-vitro-analysis of endothelial dysfunction in diabetes mellitus type 2

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