Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor

Lau, Aik Jiang; Yang, Guang; Rajaraman, Ganesh; Baucom, Christie C.; Chang, Thomas K. H.

doi:10.1016/j.jep.2012.11.038

Cited by 10 publications

(4 citation statements)

References 37 publications

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“…Ginkgolide C, a compound derived from Ginkgo biloba leaves, has anti-inflammatory and antiallergy properties and can treat ischemic and thromboembolic illnesses [ 116 , 117 ]. Pretreatment with ginkgolide C can improve the survivability of H/R-induced ventricular myocytes and their tolerance to inflammatory damage by reducing NF-B p65 subunit translocation, phosphorylation of IB, and the activity of IKK [ 118 , 119 ]. Congestive heart failure, coronary artery disease, myocardial necrosis, angina, atherosclerosis, and ischemia-reperfusion injury are all treated by arjunolic acid, a powerful component of Terminalia arjuna bark [ 120 , 121 ].…”

Section: Plant-derived Phytochemicals In Prevention and Treatment Of Cvdmentioning

confidence: 99%

Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

Bachheti

Abate

Gonfa

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cardiovascular diseases (CVDs) are the world’s leading killers, accounting for 30% deaths. According to the WHO report, CVDs kill 17.9 million people per year, and there will be 22.2 million deaths from CVD in 2030. The death rates rise as people get older. Regarding gender, the death rate of women by CVD (51%) is higher than that of men (42%). To decrease and prevent CVD, most people rely on traditional medicine originating from the plant (phytochemicals) in addition to or in preference to commercially available drugs to recover from their illness. The CVD therapy efficacy of 92 plants, including 15 terrestrial plants, is examined. Some medicinal plants well known to treat CVD are, Daucus carota, Nerium oleander, Amaranthus Viridis, Ginkgo biloba, Terminalia arjuna, Picrorhiza kurroa, Salvia miltiorrhiza, Tinospora cordifolia, Mucuna pruriens, Hydrocotyle asiatica, Bombax ceiba, and Andrographis paniculate. The active phytochemicals found in these plants are flavonoids, polyphenols, plant sterol, plant sulphur compounds, and terpenoids. A general flavonoid mechanism of action is to prevent low-density lipoprotein oxidation, which promotes vasodilatation. Plant sterols prevent CVD by decreasing cholesterol absorption in the blood. Plant sulphur compound also prevent CVD by activation of nuclear factor-erythroid factor 2-related factor 2 (Nrf2) and inhibition of cholesterol synthesis. Quinone decreases the risk of CVD by increasing ATP production in mitochondria while terpenoids by decreasing atherosclerotic lesion in the aortic valve. Although several physiologically active compounds with recognized biological effects have been found in various plants because of the increased prevalence of CVD, appropriate CVD prevention and treatment measures are required. More research is needed to understand the mechanism and specific plants’ phytochemicals responsible for treating CVD.

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Section: Plant-derived Phytochemicals In Prevention and Treatment Of Cvdmentioning

confidence: 99%

Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

Bachheti

Abate

Gonfa

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Some studies and clinical trials have observed that Ginkgo biloba L. shows potent actions on cardiovascular system and cerebral vascular activity. Furthermore, due to its antioxidant properties, it has been used in Alzheimer's patients [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Determination of Total Flavonoids Contents and Antioxidant Activity ofGinkgo bilobaLeaf by Near-Infrared Reflectance Method

Zhao

Liu

Xiong

et al. 2018

International Journal of Analytical Chemistry

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Background Total flavonoids content (TFC) is one of the most important quality indexes of Ginkgo biloba leaf, and it is concerned with total antioxidant activity. Near-infrared spectroscopy (NIR) method has showed its advantages in fast, accurate, qualitative, and quantitative analysis of various components in many quality control researches. In this study, a calibration model was built by partial least squares regression (PLSR) coupling with NIR spectrum to quantitatively analyze the TFC and total antioxidant activity of Ginkgo biloba leaf. Results During the model establishing, some spectrum pretreatment and outlier diagnosis methods were optimized to establish the final model. The coefficients of determination (R2) for TFC and total antioxidant activity prediction were 0.8863 and 0.8486, respectively; and the root mean square errors of prediction (RMSEP) were 2.203 mg/g and 0.2211 mM/g, respectively. Conclusion These results showed that NIR method combined with chemometrics is suitable for quantitative analysis of main components and their activities and might be applied to quality control of relevant products.

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“…Along with GBL, the reddish APL is also excellent as a natural antioxidant because it has accumulated a large amount of anthocyanins. In some clinical trials, GBL has potent ef icacy in cardiovascular or cerebrovascular activity, and it is also applied to Alzheimer's patients due to its natural antioxidant (Lau et al, 2013). Total lavonoid content is used as an important qual-ity index for GBL and APL and lavonoids are the main chemical component of the standard extract of G. biloba leaf (EGB761) (more than 24% of the mass).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Antioxidative Efficacy of Ginkgo Biloba Leaves and Acer Palmatum Leaves

Park

2020

ijrps

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Modern people pay attention to the antioxidant effects that protect human aging and damage, but active ingredients used in cosmetics or pharmaceutical raw materials of synthetic ingredients are exposed to a number of problems. An alternative method for solving the problem was selected, and Ginkgo Biloba Leaves (GBL) and Acer Palmatum Leaves (APL) were selected to compare and analyze antioxidant efficacy evaluations such as total polyphenol, total flavonoid, DPPH ability, ABTS radical scavenging ability, and FRAP activity measurement. In the results of the study, GBL and APL showed DPPH activity at all concentrations (μg/ml). ABTS activity and FRAP Value also showed antioxidant activity in both GBL and APL and in particular, APL has been found to be potent and is considered a rich antioxidant. ABTS activity and FRAP Value also showed antioxidant activity in both GBL and APL, and in particular, APL has been found to be more potent. Therefore, these species can be evaluated as rich antioxidants. This study hopes to provide GBL and APL extracts as data for the development of natural antioxidants in cosmetics and pharmaceuticals.

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Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor

Cited by 10 publications

References 37 publications

Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

Prevention and Treatment of Cardiovascular Diseases with Plant Phytochemicals: A Review

Determination of Total Flavonoids Contents and Antioxidant Activity ofGinkgo bilobaLeaf by Near-Infrared Reflectance Method

Comparison of Antioxidative Efficacy of Ginkgo Biloba Leaves and Acer Palmatum Leaves

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