Abstract:Surfactant Protein D (SP-D), an essential protein related to innate immunity, is expressed in multiple tissue types throughout the body. A closely-related protein, Surfactant Protein A (SP-A), is present in the mouse retina and is associated with neovascularization (NV) in the Oxygen-Induced Retinopathy (OIR) mouse model, mimicking retinopathy of prematurity (ROP). We hypothesized that SP-D would be present in the retina and is also associated with OIR and ROP, which is one of the leading causes of pediatric b… Show more
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