Evaluation of Genetic Variants in MicroRNA-Related Genes and Risk of Bladder Cancer

Yang, Hushan; Dinney, Colin P.; Ye, Yuanqing; Zhu, Yong; Grossman, H. Barton; Wu, Xifeng

doi:10.1158/0008-5472.can-07-5991

Cited by 241 publications

(212 citation statements)

References 47 publications

(55 reference statements)

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“…Recently, SNPs that could affect response to miRs were noted in miR target site sequences (159,160). Correlations between miR polymorphisms and SNPs in miR target sites with risk of bladder and colorectal cancers were reported (161)(162)(163). Hence, examination of SNPs in miR-binding sites may also provide key insights into various human diseases.…”

Section: Clinical Applications Therapeutic Strategies and Perspectivesmentioning

confidence: 99%

MicroRNAs and Their Role in Progressive Kidney Diseases

Kato

Arce

Natarajan

2009

Clinical Journal of the American Society of Nephrology

145

105

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MicroRNAs (miRs) are a family of short non-coding RNAs. These endogenously produced factors have been shown to play important roles in gene regulation. The discovery of miRs has greatly expanded our knowledge of gene regulation at the posttranscriptional level. miRs inhibit target gene expression by blocking protein translation or by inducing mRNA degradation and therefore have the potential to modulate physiologic and pathologic processes. The imperative need to determine their cellular targets and disease relevance has sparked an unprecedented explosion of research in the miR field. Recent findings have revealed critical functions for specific miRs in cellular events such as proliferation, differentiation, development, and immune responses and in the regulation of genes relevant to human diseases. Of particular interest to renal researchers are recent reports that key miRs are highly expressed in the kidney and can act as effectors of TGF-␤ actions and high glucose in diabetic kidney disease. Moreover, podocyte-specific deletion of Dicer, a key enzyme involved in miR biogenesis, led to proteinuria and severe renal dysfunction in mice. Hence, studies aimed at determining the in vitro and in vivo functions of miRs in the kidney could determine their value as therapeutic targets for progressive renal glomerular and tubular diseases. Translational approaches could be facilitated by the development of effective inhibitors of specific miRs and methods for optimal delivery of anti-miRs to the kidney. The major goal of this review is to highlight key functions of these miRs and their relationships to human diseases, with special emphasis on diabetic kidney disease.

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Section: Clinical Applications Therapeutic Strategies and Perspectivesmentioning

confidence: 99%

MicroRNAs and Their Role in Progressive Kidney Diseases

Kato

Arce

Natarajan

2009

Clinical Journal of the American Society of Nephrology

145

105

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“…[9][10][11][12][13] It is possible that association of miRNA polymorphisms may be cancer specific. However, the non-significant results of our study could be explained because of inherent difficulties in validating and replicating association studies with complex traits such as cancer and/or as a consequence of ethnic variation.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Various single nucleotide polymorphisms (SNPs) are known to exist in miRNA genes, which can lead to variations in the quantity of miRNAs resulting in diverse functional consequences and, therefore, may represent ideal candidate biomarkers for cancer prognosis. 8 Various genetic association studies have explored the function of pre-miRNA polymorphisms in cancers including non-small cell lung cancer (NSCLC), 9 breast cancer, 10 hepatocellular carcinoma, 11 bladder cancer 12 and papillary thyroid carcinoma. 13 However, the function of genetic variants of miRNA genes in GBC is yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population

Srivastava

Mittal

2010

J Hum Genet

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MicroRNAs (miRNAs) are small, non-coding RNA molecules that function as negative regulators of gene expression. Common genetic variants (single nucleotide polymorphisms, SNPs) in miRNA genes may alter their expression or maturation resulting in varied functional consequences. Present case-control study evaluated the potential association of three SNPs (rs2910164, rs11614913 and rs3746444) in pre-miRNAs with gallbladder cancer (GBC) risk in 230 GBC cases and 230 controls in a North Indian population. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated for the association of individual SNPs and their interactions with GBC. A non-significant increased risk was observed between carriers of variant genotypes of rs2910164, rs11614913 and rs3746444 (ORs¼1.3, 1.3 and 1.1, respectively). This increased risk was more profound in GBC patients with gallstones (ORs¼1.4, 1.6 and 1.1, respectively). To further evaluate the cumulative effects of the variant allele, we did a combined unfavorable genotype analysis, which showed a borderline statistical significance. In comparison with the low-risk group (0-2 variant alleles), the high-risk group (42 variant alleles) had a 1.7-fold (95% CI¼1.0-2.8) increased risk for GBC (P trend ¼0.056). These findings suggest, for the first time, that common miRNA variants may not contribute to GBC susceptibility in North Indian population.

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“…Wu et al 56 studied 100 human tumor tissues and 20 cancer cell lines and have identified a mutation in miRNA let-7e that causes a significant reduction of its expression in vivo contributing to tumorigenesis. A similar study by Yang et al 57 has genotyped several SNPs from miRNA genes in 746 matched normal and bladder cancer tissues and discovered that SNPs in GEMIN3 gene can affect miRNA binding, thereby significantly increasing bladder cancer risk.…”

Section: Micrornas In Complex Diseasesmentioning

confidence: 95%