Evaluation of Gd-DOTA-labeled dextran polymer as an intravascular MR contrast agent for myocardial perfusion

Casali, Cendrine; Janier, Marc; Canet, Emmanuelle; Obadia, Jean François; Benderbous, Soraya; Corot, Claire; Revel, D.

doi:10.1016/s1076-6332(98)80109-8

Cited by 55 publications

(43 citation statements)

References 6 publications

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“…As shown in a previous study, CMD-A2-GD-DOTA is a high relaxivity contrast agent and the dose required in this study was fivefold less than that needed for Gd-DOTA (19). In the present study, the intravascular properties of the new contrast agent have been demonstrated by output comparison with a standard intravascular indicator.…”

Section: Discussionsupporting

confidence: 67%

Kinetic characterization of CMD-A2-Gd-DOTA as an intravascular contrast agent for myocardial perfusion measurement with MRI

et al. 2000

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Section: Discussionsupporting

confidence: 67%

Kinetic characterization of CMD-A2-Gd-DOTA as an intravascular contrast agent for myocardial perfusion measurement with MRI

et al. 2000

Self Cite

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“…Using eq 2, k wl can be rewritten in terms of the liposomal molar concentration [l] (4) where f(r) is the fraction of liposomes with radius r, and N A is Avogadro's number. Thus the exchange rate is directly proportional to the membrane permeability and the total membrane surface area.…”

Section: Theorymentioning

confidence: 99%

Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes

et al. 2008

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Liposome-based chemical exchange saturation transfer (lipoCEST) agents have shown great sensitivity and potential for molecular magnetic resonance imaging (MRI). Here we demonstrate that the size of liposomes can be exploited to enhance the lipoCEST contrast. A concise analytical model is developed to describe the contrast dependence on size for an ensemble of liposomes. The model attributes the increased lipoCEST contrast in smaller liposomes to their larger surface-to-volume ratio, causing an increased membrane water exchange rate. Experimentally measured rates correlate with size, in agreement with the model. The water permeability of liposomal membrane is found to be 1.11 ± 0.14 μm/s for the specific lipid composition at 22 °C. Availability of the model allows rational design of the size of liposomes and quantification of their properties. These new theoretical and experimental tools are expected to benefit applications of liposomes to sensing the cellular environment, targeting and imaging biological processes, and optimizing drug delivery properties.

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“…CMD-A2-Gd-DOTA has been shown to be a potential intravascular contrast agent for studying myocardial perfusion with MR imaging (5).…”

mentioning

confidence: 99%

Blood pool contrast agent CMD-A2-Gd-DOTA-enhanced MR imaging of infarcted myocardium in pigs

Kroft

Doornbos

Geest

et al. 1999

J. Magn. Reson. Imaging

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Evaluation of Gd-DOTA-labeled dextran polymer as an intravascular MR contrast agent for myocardial perfusion

Cited by 55 publications

References 6 publications

Kinetic characterization of CMD-A2-Gd-DOTA as an intravascular contrast agent for myocardial perfusion measurement with MRI

Kinetic characterization of CMD-A2-Gd-DOTA as an intravascular contrast agent for myocardial perfusion measurement with MRI

Size-Induced Enhancement of Chemical Exchange Saturation Transfer (CEST) Contrast in Liposomes

Blood pool contrast agent CMD-A2-Gd-DOTA-enhanced MR imaging of infarcted myocardium in pigs

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