Evaluation of gastric motility through surface electrogastrography in critically ill septic patients. Comparison of metoclopramide and domperidone effects: A pilot randomized clinical trial

Asencio, C. Mancilla; Gálvez-Arévalo, L.R.; Tobar, Eduardo; Landskron-Ramos, G.; Madrid-Silva, A.M.

doi:10.1016/j.rgmxen.2018.06.009

Cited by 8 publications

(12 citation statements)

References 32 publications

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“…We included 102 studies with a total of 8830 patients (Figure 1). Eighty‐six studies (84%) were clinical trials 13–98 and 16 (14%) were observational studies 99–114 . Nine studies (7%) were only available in the form of a conference abstract; seven clinical trials and two observational studies 88–93,96,100,107 .…”

Section: Resultsmentioning

confidence: 99%

“…The most frequently assessed patient‐centred adverse events in both ICU and non‐ICU setting were adverse events related to the cardiovascular system ( n = 26) 13,15,17,19,22,29,36,37,42–44,53,59,65,67,68,76,77,80,82,83,87,99,107,112,113 including mean blood pressure, heart rate, arrhythmias, changes in electrocardiogram and QT‐prolongation. This was followed by different GI symptoms, which were assessed in 24 studies 13,14,26,29,32,34,36,38,40,47,49,53,54,59,65,67,69,74,76,80,83,99,110,112 .…”

Section: Resultsmentioning

confidence: 99%

“…All 58 studies in the ICU reported non‐patient‐centred outcomes. In total 41 studies 13–23,25–37,40,41,44–46,50–52,54–56,76,85,92,95,100,101 addressed gastric emptying, which was reported in different ways, for example, as gastric residual volume 15–23,26,27,30,32,36,40,41,44–47,49,52,54–56,76,92,95,100,101 or the percentage of enteral nutrition received 14,21,23,26,29,36,40,41,47,49,54,99,102 …”

Section: Resultsmentioning

confidence: 99%

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Use of prokinetic agents in hospitalised adult patients: A scoping review

Crone

Møller

Bækgaard

et al. 2023

Acta Anaesthesiol Scand

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Background: Gastrointestinal motility is important for adequate uptake of fluids and nutrition but is often impaired in hospitalised patients. Prokinetic agents enhance gastrointestinal motility and are prescribed for many hospitalised patients. In this scoping review, we aimed to systematically describe the body of evidence on the use of prokinetic agents in hospitalised patients. We hypothesised, that the body of evidence would be limited and derive from heterogeneous populations. Methods: We conducted this scoping review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews statement. We searched Medline, Embase, Epistemonikos and the Cochrane Library for studies assessing the use of prokinetic agents on any indication and outcome in adult hospitalised patients. We used a modified version of the Grading of Recommendations Assessment, Development and Evaluation (GRADE) to assess the certainty of evidence. Results:We included 102 studies with a total of 8830 patients. Eighty-six studies were clinical trials (84%), and 52 (60%) of these were conducted in the intensive care unit, with feeding intolerance as the main indication. In the non-intensive care setting the indications were wider; most studies assessed use of prokinetic agents before gastroscopy to improve visualisation. The most studied prokinetic agent was metoclopramide (49% of studies) followed by erythromycin (31%). In total 147 outcomes were assessed with only 67% of the included studies assessing patient-centred outcomes, and with gastric emptying as the most frequently reported outcome. Overall, the data provided no firm evidence on the balance between the desirable and undesirable effects of prokinetic agents. Conclusions:In this scoping review, we found that the studies addressing prokinetic agents in hospitalised adults had considerable variations in indications, drugs and outcomes assessed, and that the certainty of evidence was judged to be low to very low.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Use of prokinetic agents in hospitalised adult patients: A scoping review

Crone

Møller

Bækgaard

et al. 2023

Acta Anaesthesiol Scand

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“…One study demonstrated a dose–response relationship for the effect of domperidone [ 19 ]. A recently published parallel-group trial on patients with septic shock showed no significant difference in terms of gastric electrical rhythm measured by surface electrogastrography [ 20 ]. Taken together, the present study indicates the potential for domperidone administered via the feeding tube in the treatment of patients with EFI, but the optimal dose, route of administration, and comparable dose of metoclopramide should be taken into consideration when designing future studies.…”

Section: Discussionmentioning

confidence: 99%

Association between Domperidone Administered via Feeding Tube and Feeding Success in Critically Ill Patients with Enteral Feeding Intolerance

Cheng

Chen

Yang

et al. 2021

JPM

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One nutritional challenge in critically ill patients is enteral feeding intolerance (EFI), but current prokinetic agents have uncertain efficacy and safety profiles. We conducted a longitudinal, single-center, retrospective study to evaluate the efficacy and safety of domperidone administered via the feeding tube versus intravenous (IV) metoclopramide among adult patients with EFI. The primary outcome was feeding success, defined as the proportion of patients with average percentage of daily protein prescription >80% of the target dose. The secondary outcomes were safety endpoints. Among 28,814 intensive care unit (ICU) admissions, 552 patients with EFI were included, 38 receiving IV metoclopramide and 514 receiving tube feeding domperidone. The proportion of feeding success in patients receiving tube feeding domperidone and IV metoclopramide was 42.02% and 21.05%, respectively. After 1:2 matching (IV metoclopramide to tube feeding domperidone), the proportion of feeding success was 40.79% in patients receiving tube feeding domperidone. Basically, after matching, there were no differences in any safety endpoints (mortality and length of stay during ICU and hospitalization, organ-support-treatment free days) or adverse events (recurrence of EFI, electrolyte disturbance, abdominal and other symptoms) between the two groups (p > 0.05). A logistic regression analysis in the matched cohort indicated that domperidone administered via the feeding tube was independently associated with feeding success. We found that tube feeding domperidone was efficient in increasing enteral nutrition delivery performance among critically ill adult patients with EFI.

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“…Our study was motivated by previous evidence that core disgust images reduce normogastric activity, 11,12 although domperidone restores normogastric activity. 18 We predicted that gastric dysrhythmias may be one important cause of disgust avoidance. We report that domperidone reduces oculomotor avoidance of disgusting images after an exposure intervention.…”

Section: Reportmentioning

confidence: 99%