Evaluation of gastric motility by Fourier analysis of condensed images

Linke, Rainer; Muenzing, Wolfgang; Hahn, Klaus; Tatsch, Klaus

doi:10.1007/s002590000331

Cited by 17 publications

(36 citation statements)

References 21 publications

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“…Thereafter, blood samples were taken at 30-min intervals until 330 min. The scrambled eggs and Jell-O were labeled with 99m Tc-Sn-colloid at ϳ70 MBq for measurements of gastric emptying by high-resolution scintigraphy (20 images/min; Orbiter, Siemens, Erlangen, Germany) starting immediately after completion of the meal and continuing for the remainder of the experiment (14,15).…”

Section: Subjectsmentioning

confidence: 99%

“…Completion of gastric emptying was assumed at a reduction of the initial activity to Ͻ5%. Loss of activity was corrected for the radioactive half-life of 99mTc (14). According to the procedure guidelines of The Society of Nuclear Medicine (6), a continuous framing rate of 30 -60 s is recommended to accurately determine lag phase and half-time of gastric emptying.…”

Section: Subjectsmentioning

confidence: 99%

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Importance of changes in gastric emptying for postprandial plasma glucose fluxes in healthy humans

Woerle¹,

Albrecht²,

Linke³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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Objective: Regulation of postprandial (pp) plasma glucose excursions is complex. Insulin and glucagon are thought to play the predominant role. Nevertheless, only 50% of the variation in pp plasma glucose excursions is explained by variations by the latter. Theoretically, gastric emptying (GE) should be another important factor. However, its impact on pp glucose homeostasis is unknown. Research Design and Methods: We examined the consequences of pramlintide-induced delay in GE on pp glycemia and glucose fluxes, determined isotopically. GE was recorded by scintigraphy. Fourteen healthy subjects (8 men, 6 women; age 40 ± 3 yr, body mass index 27.8 ± 1.1 kg/m2) ate a mixed meal, and 30 μg of pramlintide (PRAM) or placebo (PBO) were injected subcutaneously. Results: At 60 min, greater proportions of the initial gastric contents remained in the stomach (PBO vs. PRAM). Thereafter, GE slopes paralleled until 240 min. Fifty percent retention times were lower when PBO was given ( P < 0.001). GE was greater from 240 min to the end of the PRAM experiments, so that only slightly greater proportions of the meal remained in the stomach at 330 min. Reductions of GE lowered pp glucose (7.5 ± 0.3 vs. 6.0 ± 0.2 mmol/l, P < 0.001), even though plasma insulin was lower with PRAM (164 ± 13 vs. 138 ± 13 pmol/ml, both P < 0.01). Reduction in total glucose appearance ( P < 0.001) was due to reduced meal-derived glucose appearance (10.2 ± 0.5 vs. 7.0 ± 0.4 μmol·kg−1·min−1, P < 0.001). Endogenous glucose appearance was greater with PRAM ( P < 0.001). Splanchnic glucose uptake was greater with PRAM (26.5 ± 1.6 vs. 32.5 ± 2.1%, P = 0.014). Conclusions: These data support the concept that GE is an important physiological regulator of pp glucose homeostasis in humans.

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Section: Subjectsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Importance of changes in gastric emptying for postprandial plasma glucose fluxes in healthy humans

Woerle¹,

Albrecht²,

Linke³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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“…The study protocol has been published previously [11]. After an overnight fast, the subjects were asked to ingest a standardized semisolid test meal consisting of 25 g oatmeal (Kölln Schmelzflocken®], Elmshorn, Germany) dissolved in 400 ml of water (temperature 37-40 °C) labeled with 60-70 MBq 99mTc-Sn-colloid.…”

Section: Materials and Methods S Subjectsmentioning

confidence: 99%

“…During the time period from the 10-17th minute, the frame rate was increased to 20 frames per minute in order to analyze gastric motor function as previously described [11,14]. Data were acquired in a 64 ϫ 64 matrix.…”

Section: Materials and Methods S Subjectsmentioning

confidence: 99%

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An advanced approach for the assessment of gastric motor function in long-term Type 1 diabetes mellitus with and without autonomic neuropathy

Meier¹,

Linke²,

Tatsch³

et al. 2002

Clinical Autonomic Research

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Gastric motor dysfunction is a frequent and deleterious long-term complication in diabetes mellitus (DM) but the exact contribution of diabetic autonomic dysfunction remains unclear. The aim of this study was to assess indices of gastric motor function in long-term Type 1 DM in the light of the presence and absence of autonomic neuropathy by means of an advanced dynamic scintigraphic technique. Gastric scintigraphy with condensed images of a short dynamic sequence was applied to 27 long-term Type 1 diabetic patients (duration > 10 years) and 15 control subjects. Two indices of gastric peristalsis, the frequency of contractions (FC) and amplitude of contractions (AC), were assessed scintigraphically together with half-time of gastric emptying (t 1/2). Five cardiac reflex tests were performed to study electrocardiogram (ECG)-based cardiac autonomic neuropathy (CAN). Mean AC was significantly decreased in diabetic patients compared to control subjects (13 +/- 9% vs. 28 +/- 8%, p < 0.005). Mean FC was comparable between diabetic patients and control subjects min(-1). (3.1 +/- 0.4 min(-1) vs. 3.1 +/- 0.2 Compared to control subjects, half-time of gastric emptying was significantly prolonged in diabetic patients (31 +/- 17 min vs. 20 +/- 3 min, p < 0.001). Mean AC, FC and t 1/2 did not differ significantly between diabetic patients with (n = 10) and without (n = 17) ECG-based CAN. Our study demonstrates that in both long-term Type 1 DM with and without autonomic neuropathy, the amplitude but not the frequency of gastric contractions, is frequently reduced. A delay of gastric emptying in Type 1 DM is confirmed although it was independent from the presence of cardiac autonomic neuropathy (CAN). Analyzing gastric motor function with dynamic scintigraphic techniques using condensed images is a promising clinical approach to further elucidate the mechanisms of impaired gastric motility in DM.

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Gastric motor function and emptying in the right decubitus and seated body position as assessed by magnetic resonance imaging

Treier

Steingoetter

Weishaupt

et al. 2006

Magnetic Resonance Imaging

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Purpose:To determine the effect of the right decubitus lying body position (RP) on relevant parameters of human gastric motor function in healthy volunteers. Materials and Methods:Postprandial gastric function after ingestion of a solid/liquid meal (150 g/150 mL) was assessed over 90 minutes in volunteers in the RP and seated position (SP). Ten healthy volunteers were imaged using two MRI systems that differed in architecture and field strength. Stomach and intragastric air volume, intragastric meal distribution, gastric emptying, and gastric peristalsis were compared between the RP and SP.Results: Body position did not affect gastric relaxation (RP, 372 mL vs. SP, 384 mL) and initial gastric volumes (stomach: RP, 458 mL vs. SP, 462 mL; meal: RP, 377 mL vs. SP, 399 mL; intragastric air: RP, 110 mL vs. SP, 98 mL). Postprandial stomach volume and gastric activity (RP and SP, 3.1 minute -1 ) were also similar. Meal emptying showed different characteristics, resulting in a significant but small difference in meal volume of -43 mL at t ϭ 90 minutes (P Ͻ 0.05). Conclusion:Gastric MRI in RP is feasible for clinical research assessing gastric motor function. The subtle difference in meal emptying may be induced by posture-dependent vagal activity. This study confirms that MRI is a highly sensitive imaging technique for assessing gastrointestinal function in humans. MAGNETIC RESONANCE IMAGING (MRI) has been established as a valuable technique in human gastrointestinal (GI) research for analyzing gastric function (1-4). In comparison with radionuclide and ultrasound imaging methods, MRI offers improved spatial and temporal image resolution, and thus is ideal for noninvasive and reliable assessment of GI physiology (5). It will therefore play an important role in GI research and clinical diagnosis in the future (6,7).The most common body position during and following meal ingestion is sitting; however, the horizontally aligned whole-body architecture of modern high-field MRI systems restricts measurements of organ function to the lying body position. Several studies using ␥-scintigraphy (8 -12), intraluminal manometry (9), and MRI (13) have shown that posture influences gastric function, and thus may present a limitation for gastric MRI. In those studies, however, gastric emptying was analyzed only at discrete time points, and peristaltic motility was determined as antropyloroduodenal pressure events. Differences in the gastric emptying rate and the number of antropyloric contraction waves were detected between the lying and seated positions. Because of the very different measurement principles involved (i.e., radioactive decay vs. hydrostatic pressure vs. MR), scintigraphy and manometry data are not directly comparable with data derived using MRI. To evaluate gastric MRI for its use in clinical research and diagnosis of GI pathophysiology, one must simultaneously investigate gastric emptying, stomach volume, intragastric meal distribution, and gastric peristalsis in the lying position and detect differences compared to th...

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Evaluation of gastric motility by Fourier analysis of condensed images

Cited by 17 publications

References 21 publications

Importance of changes in gastric emptying for postprandial plasma glucose fluxes in healthy humans

Importance of changes in gastric emptying for postprandial plasma glucose fluxes in healthy humans

An advanced approach for the assessment of gastric motor function in long-term Type 1 diabetes mellitus with and without autonomic neuropathy

Gastric motor function and emptying in the right decubitus and seated body position as assessed by magnetic resonance imaging

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