Evaluation of garlic oil in nano-emulsified form: Optimization and its efficacy in high-fat diet induced dyslipidemia in Wistar rats

Ragavan, Gokulakannan; Muralidaran, Yuvashree; Sridharan, Badrinathan; Ganesh, Rajesh Nachiappa; Viswanathan, Pragasam

doi:10.1016/j.fct.2017.04.019

Cited by 50 publications

(26 citation statements)

References 42 publications

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“…One possible mechanism by which dyslipidemia leads to cardiovascular disorders is the generation of free radicals and oxidative stress (Singh et al, 2016). Previous studies demonstrated the antioxidant and antihyperlipidemic potential of both garlic oil and kenaf seed oil (Ragavan et al, 2017;Cheong et al, 2018). Garlic (Allium sativum L.) oil mostly constitutes sulfurcontaining compounds such as alliin, allicin, diallyl sulfide, diallyl disulfide, and diallyl trisulfide which are responsible for antidiabetic, antihyperlipidemic and anti-atherogenic effects (Zheng et al, 2013;Sambu et al, 2015;Ebrahimzadeh-Bideskan et al, 2016).…”

Section: Dyslipidemiamentioning

confidence: 99%

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Nouri

Hajialyani

Izadi

et al. 2020

Front. Bioeng. Biotechnol.

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Metabolic syndrome includes a series of metabolic abnormalities that leads to diabetes mellitus and cardiovascular diseases. Plant extracts, due to their unique advantages like anti-inflammatory, antioxidant, and insulin sensitizing properties, are interesting therapeutic options to manage MetS; however, the poor solubility and low bioavailability of lipophilic bioactive components in the herbal extracts are two critical challenges. Nano-scale delivery systems are suitable to improve delivery of herbal extracts. This review, for the first time, focuses on nanoformulations of herbal extracts in MetS and related complications. Included studies showed that several forms of nano drug delivery systems such as nanoemulsions, solid lipid nanoparticles, nanobiocomposites, and green-synthesized silver, gold, and zinc oxide nanoparticles have been developed using herbal extracts. It was shown that the method of preparation and related parameters such as temperature and type of polymer are important factors affecting physicochemical stability and therapeutic activity of the final product. Many of these formulations could successfully decrease the lipid profile, inflammation, oxidative damage, and insulin resistance in in vitro and in vivo models of MetS-related complications. Further studies are still needed to confirm the safety and efficacy of these novel herbal formulations for clinical application.

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Section: Dyslipidemiamentioning

confidence: 99%

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Nouri

Hajialyani

Izadi

et al. 2020

Front. Bioeng. Biotechnol.

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“…This is a good agreement with Hussein et al, (2013) that the level of total cholesterol, LDL, and triglycerides are decreased on the subject that given extracts with the dose of 500 mg twice a day. A series of experiments have been conducted to examine the effects of garlic in animal studies (Ebrahimi et al, 2015;Ha et al, 2015;Perez-Torres et al, 2016;Ragavan et al, 2017). Summarizes a number of animal studies in the literature, from which we can include garlic preparations usually displayed positive effects.…”

Section: Resultsmentioning

confidence: 99%

Effects of Poly-herbal Tablet as Herbal Medicine on Lipid Level

et al. 2019

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Dyslipidemia is one of the high-risk factors that cause cardiovascular disease and the prevalence is increasing all the time. Garlic (Alii sativi) has been suggested to reduce serum lipid level. Poly-herbal is herbal medicine that has been widely used in Indonesia, and it contains Alii sativi, Belericae fructus, Curcumae aeroginosae, and Amomi fructus extract. This study aimed to evaluate the effects of poly-herbal tablet on lipid levels in dylipidemia subjects. The study was conducted for 6 weeks on 58 dyslipidemic subjects. The subject was divided into 2 groups. Group 1 was given Poly-herbal with the dose 2x1200 mg, and group 2 was not given anti-dyslipidemic drugs (control group). Serum lipid level (total cholesterol, LDL, HDL, and triglycerides) were checked before the treatment (H0) and after the treatment (M6). There was a significant difference on the reduction of serum lipids level between the group that given Poly-herbal vs control group, respectively total cholesterol (-12.04±3.2 vs 8.38±4.3; p=.000), LDL (-4.42±2.8 vs 6.93±4.7; p=.049) and HDL (-2.62+1.0 vs 3.31+1.4; p=.005). Triglyceride level on Poly-herbal group is not significantly decreased. In Poly-herbal group there was also a decrease in HDL levels which was not statistically significant (-2.62±1, p=.015). This is probably due to the HDL baseline in the control group included in the normal HDL category (57.38 ± 14.9) so that the HDL levels after being given treatment did not increase. This study suggests that using Poly-herbal in dyslipidemia subjects can reduce the level of total cholesterol and LDL.

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“…Ragavan et al, 3 have found that formulating NE consisting of GO, tween 80 and water was very effictive in resotring the lipid profile in the mice when compared to the atorvastatin, a cholesterollowering agent, and the free GO. Moreover, the heart profile of the EAC-bearing mice treated with NEGO was amended when compared to the other tested groups.…”

Section: Discussionmentioning

confidence: 99%

“…There have many recent attempts to improve the garlic oil (GO) bioavailability by loading it in NE in order to be used clinically and to benefit from its great potential as an antitumor, anti-hypertension, antilipidemic, antithrombotic and antiplatelet aggregation 3,4 . Docetaxel (Doc) is an effective antineoplastic agent that is used to treat numerous kinds of cancers, such as breast, ovarian, gastric, non-small and small cell lung cancers.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

IJPSR

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Docetaxel (Doc) is an antitumor drug used to treat various types of cancers. However, it has certain limitations in clinical use due to its side effects. The major objective of this study was to assess the antitumor activity and cardiotoxicity of the Doc loaded in a nanoemulsion formulated with the garlic oil (Doc-NEGO) in Ehrlich ascites carcinoma (EAC)-bearing mice. One hundred mice were split into five groups (n = 20). Groups I and II served as untreated mice and untreated EAC-bearing mice, respectively. Groups III-V represented the EAC-bearing mice administered orally by Doc-NEGO, NEGO and Doc dissolved in distilled water, respectively. The antitumor activity included the measurement of the mean survival time (MST) and the lactate dehydrogenase (LDH) activity in the tumor ascetic fluid. The cardiotoxicity was identified by determining the serum enzymes and analyzing the oxidative stress in the heart tissue. It has been found that the z-average diameters of the nanoparticles of NEGO and Doc-NEGO, determined by the zetasizer, were 63.19 ± 1.85 nm and 110.43 ± 14.37 nm, respectively. The administration of NEGO in the EAC-bearing mice has enhanced the LDH activity in the ascetic fluid and ameliorated the heart enzymes when compared to the other groups. Treating the EAC-bearing mice with the Doc-NEGO has improved the MST of the mice (27.7 ± 11.63 days) relative to the MST of EAC-bearing mice treated with Doc-water (23.1 ± 1.52 days). In conclusion, NEGO holds a great potential as a nanocarrier for the Doc in improving its efficacy and eliminating its cardiotoxicity.

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Evaluation of garlic oil in nano-emulsified form: Optimization and its efficacy in high-fat diet induced dyslipidemia in Wistar rats

Cited by 50 publications

References 42 publications

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Effects of Poly-herbal Tablet as Herbal Medicine on Lipid Level

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