Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient

Abstract

Hyperglycemic environment-induced oxidative stress-mediated matrix metalloproteinase-1 (MMP-1) plays a crucial role in the degradation of the extracellular matrix (ECM), which might contribute to premature skin aging. Synthesized, environmentally friendly gallic acid-coated gold nanoparticles (GA–AuNPs) have been evaluated as an anti-aging antioxidant. Their microstructure was characterized by transmission electron microscopy (TEM), which showed that GA–AuNPs are spherical when prepared at pH 11. Dynamic light scattering (DLS) analysis revealed that the average hydrodynamic diameter of a GA–AuNP is approximately 40 nm and with a zeta potential of −49.63 ± 2.11 mV. Additionally, the present data showed that GA–AuNPs have a superior ability to inhibit high glucose-mediated MMP-1-elicited type I collagen degradation in dermal fibroblast cells. Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA–AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFκB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells. Our findings suggest that GA-AuNPs have a superior ability to inhibit high-glucose-mediated MMP-1-elicited ECM degradation, which highlights its potential as an anti-aging ingredient.

Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development

“…Gold nanoparticles (GNPs) are excellent biological carriers because of their good biocompatibility. Moreover, gold is also reported to be an anti-aging metal [ 17 ].…”

In Situ Green Synthesis of Graphene Oxide-Silver Nanoparticles Composite with Using Gallic Acid

“…In the process of synthesizing metal nanoparticles by reduction method, the reaction pH has a crucial influence on the synthesis success or failure of metal nanoparticles ( Wu, et al, 2021 ). To explore the effect of reaction pH on the number and morphology of AgNPs in GO-AgNPs, we synthesized GO-AgNPs at reaction pH of 3, 5, 7, 9, 11, and 13, respectively, and subjected them to Uv-vis characterization analysis.…”

Molecular docking of gallic acid as anti-photoaging in silico

“…The cationic CTAB niosomes loaded with gallic acid demonstrated the highest anti-skin aging activity, including antioxidant (87.03 ± 0.99% cell viability) and inhibition of matrix metalloproteinase-2 (38.46 ± 1.53% of control) [20]. Another in vitro study on the inhibitory activity of gallic acid against MMP-1 in human nasopharyngeal carcinoma cells showed that gallic acid was able to inhibit the excessive production of ROS induced by UV light and was able to inhibit the activity of MMP-1 [21]. Other study examined gallic acid glucoside's potential as a cosmetic ingredient, including its antioxidant and anti-aging effects exerted by MMP-1 and collagen content.…”