Evaluation of functional characteristics of preactivated thiolated chitosan as potential therapeutic agent for dry mouth syndrome

Laffleur, Flavia; Fischer, Alexander; Schmutzler, Matthias; Hintzen, Fabian; Bernkop‐Schnürch, Andreas

doi:10.1016/j.actbio.2015.04.016

Cited by 32 publications

(16 citation statements)

References 30 publications

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“…The manufactured polymeric discs comprising HA and HA–SH were evaluated for its water uptake capacity in various body fluids following a gravimetric method . The initial weight ( W 0 ) was determined and discs were immersed in simulated body fluids.…”

Section: Methodsmentioning

confidence: 99%

Comparative mucoadhesive study of hyaluronic acid‐based conjugates on different mucosae

Laffleur

2017

J of Applied Polymer Sci

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The incentive of this study was to provide a detailed mucoadhesive comparison on adhesive properties on diverse mucosal surfaces such as nasal, buccal, and vaginal mucosa, respectively. Mucoadhesive hyaluronic acid-cysteine ethyl ester (HA-SH) conjugate was synthesized by the anchorage of sulfhydryl groups (SH) on the polymeric backbone of HA via amide bond formation between the carboxylic acid moieties of hyaluronic acid and sulfhydryl groups of cysteine ethyl ester. Histology assay in terms of alcian blue staining was performed on mucosal tissue in order to evaluate the potential impact on viability. The proficiency of water uptake was studied in various simulated body fluid. Moreover, mucoadhesive assays based on rotating cylinder, total work of adhesion, and maximum detachment force were carried out on various mucosae. The findings revealed in presence of 2.7-, 2.6-, and 1.25-fold improvement in swelling behavior in comparison to unmodified HA on nasal, buccal, and vaginal mucosa. Furthermore, mucoadhesive studies showed a 3.2-, 2.6-, 2.6-fold more extended residence time on nasal, buccal, and vaginal in presence of HA-SH in comparison to unmodified HA, respectively. Taken together, the comprehensive mucoadhesive study serve as guidance in the development of mucoadhesive drug delivery systems for versatile application.

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Section: Methodsmentioning

confidence: 99%

Comparative mucoadhesive study of hyaluronic acid‐based conjugates on different mucosae

Laffleur

2017

J of Applied Polymer Sci

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“…Chitosan-thioglycolic-mercaptonicotinamide conjugates, which were non-toxic against Caco-2 cells and synthesized by the oxidative S-S coupling of chitosan-thioglycolic acid with 6-mercaptonicotinamide, manifested improved swelling and cohesive characteristics compared with unmodified chitosan and were promising for therapy of dry mouth syndrome in which lubrication and mucoadhesiveness of the mucosa are wanting [ 151 ].…”

Section: Applicationsmentioning

confidence: 99%

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

et al. 2015

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Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application. Nevertheless, chemical modification into composites or hydrogels brings to it new functional properties for different applications. Chitosans are recognized as versatile biomaterials because of their non-toxicity, low allergenicity, biocompatibility and biodegradability. This review presents the recent research, trends and prospects in chitosan. Some special pharmaceutical and biomedical applications are also highlighted.

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“…Hintzen et al determined also an increased viscosity for 100% preactivated polymers (Hintzen et al, 2013). Laffleur et al (2015) showed a rheological synergism for preactivated chitosan derivatives compared to unmodified polymers. Further studies could show that the rheological synergism applies not only for polymers, but also for other mucoadhesive excipients, for example nanoparticles and microemulsions (Carvalho et al, 2010).…”

Section: Discussionmentioning

confidence: 93%