Evaluation of Fractal‐Coated Temporary Pacing Leads in the Early Postoperative Course

Mellert, Fritz; Konietzko, Peter; Schneider, Christian; Gersing, E.; Kreuz, Jens; Balta, Osman; Preusse, C. J.; Welz, Armin

doi:10.1111/j.1540-8159.2007.00969.x

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…POAF is usually transient or self‐limiting, unlike other forms of AF, with a return to sinus rhythm once the atrial substrate, that is, postoperative pericarditis, resolves. The progressive increases in pacing thresholds and AERP over postoperative periods in the canine model are consistent with prior observations in patients with POAF after surgery 24–26 . In comparison with the swine sterile pericarditis model, all electrophysiologic data from the swine model were consistent with the canine sterile pericarditis model 9,13,15,16 with respect to (1) the range of both pacing threshold and AERP; (2) the progressive increase in threshold and AERP over time; (3) a 40%–50% incidence of POAF.…”

Section: Discussionsupporting

confidence: 84%

“…The progressive increases in pacing thresholds and AERP over postoperative periods in the canine model are consistent with prior observations in patients with POAF after surgery. [24][25][26] In comparison with the swine sterile pericarditis model, all electrophysiologic data from the swine model were consistent with the canine sterile pericarditis model 9,13,15,16 with respect to (1) the range of both pacing threshold and AERP; (2) the progressive increase in threshold and AERP over time; (3) a 40%-50% incidence of POAF. In addition, the swine sterile pericarditis study can be performed in the conscious closed-chest state on postoperative days.…”

Section: Swine Versus Canine Sterile Pericarditis Model For Studying ...supporting

confidence: 57%

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Validation of a new species for studying postoperative atrial fibrillation: Swine sterile pericarditis model

Lee,

Khrestian,

Laurita

et al. 2023

Pacing Clinical Electrophis

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BackgroundThe canine sterile pericarditis model associated with atrial inflammation is an experimental counterpart of postoperative atrial fibrillation (POAF). However, the use of canines for research is restricted by ethics committees in many countries, and social acceptance is declining.ObjectiveTo validate the feasibility of the swine sterile pericarditis model as an experimental counterpart to study POAF.MethodsSeven domestic pigs (35–60 kg) underwent initial pericarditis surgery. On two or more postoperative days in the closed‐chest state, we performed electrophysiological measurements of pacing threshold and atrial effective refractory period (AERP) while pacing from the right atrial appendage (RAA) and the posterior left atrium (PLA). The inducibility of POAF (>5 min) by burst pacing was determined in both the conscious and anesthetized closed‐chest state. These data were compared to previously published canine sterile pericarditis data for validation.ResultsThe pacing threshold increased from day 1 to day 3 (2 ± 0.1 to 3.3 ± 0.6 mA in the RAA, 2.5 ± 0.1 to 4.8 ± 0.2 mA in the PLA). Also, the AERP increased from day 1 to day 3 (118 ± 8 to 157 ± 16 ms in the RAA; 98 ± 4 to 124 ± 2 ms in the PLA, both p < .05). Induction of sustained POAF occurred in 43% (POAF CL range 74–124 ms). All electrophysiologic data from the swine model were consistent with the canine model with respect to (1) the range of both pacing threshold and AERP; (2) the progressive increase in threshold and AERP over time; (3) a 40%–50% incidence of POAF.ConclusionA newly developed swine sterile pericarditis model demonstrated electrophysiologic properties consistent with the canine model and patients after open heart surgery.

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Section: Discussionsupporting

confidence: 84%

Section: Swine Versus Canine Sterile Pericarditis Model For Studying ...supporting

confidence: 57%

Validation of a new species for studying postoperative atrial fibrillation: Swine sterile pericarditis model

Lee,

Khrestian,

Laurita

et al. 2023

Pacing Clinical Electrophis

View full text Add to dashboard Cite

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Detection of (Reversible) Myocardial Ischemic Injury by Means of Electrical Bioimpedance

Mellert

Winkler

Schneider

et al. 2011

IEEE Trans. Biomed. Eng.

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The scope of this paper was to determine whether ischemic and reperfusion damage in cardiac surgery can be detected by measurement of electrical bioimpedance (EBI). Conventional pacing wires were replaced by pacing wires with sputtered iridium coating in order to reduce polarization associated with two-electrode impedance measurements. A custom-built bioimpedance analyzer (Osypka Medical GmbH, Berlin, Germany) measured the real part of impedance Re(Z) and the phase (ϕ) at three frequencies (1, 10, and 1000 kHz) and determined an extracellular space index (EZRI) as the quotient of Re(Z) at 1000 kHz and Re(Z) at 1 kHz. Our study included six patients (conventional coronary artery bypass graft, age 68.1 ± 8.3 years) subject to routine cardioplegic ischemia and reperfusion. Preischemic bioimpedance measurements were not impaired by interference of the beating heart. Intraischemically, bioimpedance at 1 kHz and phase at 10 kHz increased until opening of a bypass graft, which is probably induced by closure of gap junctions and cell swelling processes. After cross clamping, EZRI slowly decreased as an effect of mild cell swelling. After ischemia, values returned almost to baseline measurements, indicating sufficient reperfusion processes. Measurement of EBI correlates with myocardial ischemic injury and is applicable in a two-electrode setup providing low-polarization pacing wires.

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Evaluation of Fractal‐Coated Temporary Pacing Leads in the Early Postoperative Course

Cited by 2 publications

References 18 publications

Validation of a new species for studying postoperative atrial fibrillation: Swine sterile pericarditis model

Validation of a new species for studying postoperative atrial fibrillation: Swine sterile pericarditis model

Detection of (Reversible) Myocardial Ischemic Injury by Means of Electrical Bioimpedance

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