Evaluation of fosfomycin combined with vancomycin against vancomycin-resistant coagulase negative staphylococci

Ibrahim, Yasser Musa; El-Wafa, Wael Mohamed Abu

doi:10.1080/1120009x.2020.1761638

Cited by 7 publications

(3 citation statements)

References 63 publications

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“…In Germany, beta-lactam antibiotics are often used as empiric therapy for VO, since the rate of methicillin-resistant S. aureus (MRSA) is less than 10% [23]. Due to the high rate of resistance of CoNS to oxacillin and other beta-lactams, as a result such empiric therapy would likely lead to higher treatment failure rates in SIVO [24,25].…”

Section: Discussionmentioning

confidence: 99%

Clinical features and outcome of vertebral osteomyelitis after spinal injection: is it worth the price?

et al. 2023

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Purpose Spinal injections are increasingly used for back pain treatment. Vertebral osteomyelitis (VO) after spinal injection (SIVO) is rare, but patient characteristics and outcome have not been well characterized. The aim of this study was to assess patient characteristics of SIVO in comparison to patients with native vertebral osteomyelitis (NVO) and to determine predictors for 1-year survival. Methods This is a single-center cohort study from a tertiary referral hospital. This is a retrospective analysis of Patients with VO who were prospectively enrolled into a spine registry from 2008 to 2019. Student’s t-test, Kruskal–Wallis test or Chi-square test were applied for group comparisons. Survival analysis was performed using a log-rank test and a multivariable Cox regression model. Results 283 VO patients were enrolled in the study, of whom 44 (15.5%) had SIVO and 239 (84.5%) NVO. Patients with SIVO were significantly younger, had a lower Charlson comorbidity index and a shorter hospital stay compared to NVO. They also showed a higher rate of psoas abscesses and spinal empyema (38.6% [SIVO] vs. 20.9% [NVO]). Staphylococcus aureus (27%) and coagulase-negative staphylococci (CNS) (25%) were equally often detected in SIVO while S. aureus was more frequently than CNS in NVO (38.1% vs. 7.9%).Patients with SIVO (P = 0.04) had a higher 1-year survival rate (Fig. 1). After multivariate analysis, ASA score was associated with a lower 1-year survival in VO. Conclusion The results from this study emphasize unique clinical features of SIVO, which warrant that SIVO should be estimated as a separate entity of VO.

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Section: Discussionmentioning

confidence: 99%

Clinical features and outcome of vertebral osteomyelitis after spinal injection: is it worth the price?

et al. 2023

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“…S. warneri [253][254][255] and S. capitis [256,257] have also joined the list with several isolates resistant to vancomycin, generating outbreaks especially in neonatal units, where S. epidermidis resistant isolates are also frequently found [258]. Fortunately, vancomycin remains an effective antibiotic against most of the CoNS isolates [189,222,245,259], being on the top list of antibiotics used to fight these infections, either alone or in combination with other antibiotics as cefazolin [209], rifampicin [213,260], and fosfomycin [261], among others. Rifampicin is also frequently used to treat staphylococcal infections; however, this antibiotic is associated with the rapid development of resistance when used alone and, as such, it should be used as part of a combined therapy [262][263][264].…”

Section: Resistance To Other Antibioticsmentioning

confidence: 99%

Virulence Factors in Coagulase-Negative Staphylococci

et al. 2021

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Coagulase-negative staphylococci (CoNS) have emerged as major pathogens in healthcare-associated facilities, being S. epidermidis, S. haemolyticus and, more recently, S. lugdunensis, the most clinically relevant species. Despite being less virulent than the well-studied pathogen S. aureus, the number of CoNS strains sequenced is constantly increasing and, with that, the number of virulence factors identified in those strains. In this regard, biofilm formation is considered the most important. Besides virulence factors, the presence of several antibiotic-resistance genes identified in CoNS is worrisome and makes treatment very challenging. In this review, we analyzed the different aspects involved in CoNS virulence and their impact on health and food.

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“…Several studies have reported that over 90% of CoNS are resistant to penicillin, 64.2% to 93.6% of CoNS are resistant to methicillin, and all CoNS are susceptible to vancomycin ( 6 – 9 ). In other studies, vancomycin- and linezolid-resistant CoNS have occasionally been reported ( 10 – 12 ). The trends are not favorable.…”

Section: Introductionmentioning

confidence: 86%

Trends of Antimicrobial Susceptibility in Clinically Significant Coagulase-Negative Staphylococci Isolated from Cerebrospinal Fluid Cultures in Neurosurgical Adults: a Nine-Year Analysis

Tian

Kong

et al. 2022

Microbiol Spectr

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Evaluation of fosfomycin combined with vancomycin against vancomycin-resistant coagulase negative staphylococci

Cited by 7 publications

References 63 publications

Clinical features and outcome of vertebral osteomyelitis after spinal injection: is it worth the price?

Clinical features and outcome of vertebral osteomyelitis after spinal injection: is it worth the price?

Virulence Factors in Coagulase-Negative Staphylococci

Trends of Antimicrobial Susceptibility in Clinically Significant Coagulase-Negative Staphylococci Isolated from Cerebrospinal Fluid Cultures in Neurosurgical Adults: a Nine-Year Analysis

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