Evaluation of Fosfomycin Activity Against Uropathogens in a Fosfomycin-Naive Population in South India: a Prospective Study

Sahni, Rani Diana; Veeraraghavan, Balaji; Varghese, Rosemol; John, James; Tansarli, Giannoula S.; Falagas, Matthew E.

doi:10.2217/fmb.13.31

Cited by 34 publications

(18 citation statements)

References 19 publications

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“…This rate is even higher than reported in some other developing countries (60−70%) (2, 5, 13, 22). By contrast, the prevalence of ESBL-producing isolates among Enterobacteriaceae in developed nations is much lower:<1% in Sweden (23) and 1.7% in France (24).…”

Section: Discussioncontrasting

confidence: 55%

“…Previous study showed that the most prevalent microorganism was E. coli , followed by K. pneumonia , and other Enterobacteriaceae (5, 6, 21, 27). A study from France in 2008 reported that the most prevalent species were E. coli (48.5%), Enterobacter aerogenes (23.7%), and K. pneumoniae (14.8%) (24).…”

Section: Discussionmentioning

confidence: 99%

“…Pan-drug resistant pathogens with acquired resistance to almost all available antimicrobial agents have emerged in recent years and challenged the treatment of infections (2, 3). Strains in the Enterobacteriaceae family have been well documented for their resistance to clinically used antibiotics (4, 5). Extended spectrum β-lactamase (ESBL) and metallo β-lactamase (MBL) production are the commonly recognized resistance mechanisms in Enterobacteriaceae strains worldwide (6).…”

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confidence: 99%

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Prevalence of 16S rRNA methylase genes among β-lactamase-producing Enterobacteriaceae clinical isolates in Saudi Arabia

Sheikh

Marie

John

et al. 2014

Libyan Journal of Medicine

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BackgroundCo production of 16S rRNA methylases gene and β-Lactamase gene among Enterobacteriaceae isolates conferring resistance to both therapeutic options has serious implications for clinicians worldwide.MethodsTo study co existence of 16S rRNA methylases (armA, rmtA, rmtB, rmtC, rmtD, and npmA) and β-Lactamase (blaTEM-1, blaSHV-12, blaCTX-M-14) genes, we screened all phenotypic positive β-Lactamase producing enterobacteriaceae by polymerase chain reaction (PCR) targeting above genes. A total of 330 enterobacteriaceae strains were collected during study period out of that 218 isolates were identified phenotypically as β-Lactamase producers, which include 50 (22.9%) Escherichia coli; 92 (42.2%) Klebsiella pneumoniae, 44 (20.2%), Citrobactor freundii and 32 (14.7%) Enterobacter spp.ResultsAmong this 218, only 188 isolates harbored the resistant gene for β-Lactamase production. Major β-Lactamase producing isolates were bla TEM-1 type. 122 (56 %) isolates were found to produce any one of the 16S rRNA methylase genes. A total of 116 isolates co produced β-Lactamase and at least one 16S rRNA methylases gene Co production of armA gene was found in 26 isolates with rmtB and in 4 isolates with rmtC. The rmtA and rmtD genes were not detected in any of the tested isolates. Six isolates were positive for a 16S rRNA methylase gene alone.Conclusionβ-Lactamase producing isolates appears to coexist with 16S rRNA methylase predominantly armA and rmtB genes in the same isolate. We conclude the major β-Lactamase and 16S rRNA methylases co-producer was K. pneumoniae followed by E. coli. We suggest further work on evaluating other β-lactamases types and novel antibiotic resistance mechanisms among Enterobacteriaceae.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Prevalence of 16S rRNA methylase genes among β-lactamase-producing Enterobacteriaceae clinical isolates in Saudi Arabia

Sheikh

Marie

John

et al. 2014

Libyan Journal of Medicine

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“…However, fosfomycin was reported to have a good activity on all UTI isolates in various studies [27,28]. In the present study, only one Enterococcus isolate was resistant to vancomycin and teicoplanin, but it was also resistant to fosfomycin.…”

Section: Discussioncontrasting

confidence: 43%

Antibacterial Activity of Fosfomycin against Uropathogens

Sun

Chen²,

Qiu³

et al. 2014

Chemotherapy

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Background: In recent years, the rising rates of resistance to antimicrobial drugs among pathogens have caused great difficulty for clinicians treating infectious diseases. The aim of the study was to assess the curative effect of fosfomycin in treating urinary tract infections (UTIs) in China. Methods: We collected clinical isolates of UTIs to determine their susceptibility to fosfomycin by the agar dilution method and to analyze extended-spectrum β-lactamase (ESBL)-producing isolates by the double-disc method on Mueller-Hinton agar. Fosfomycin-modifying enzyme analysis was conducted by PCR. Differences between the different groups were determined by the χ² test. Results: We collected 433 UTI isolates, and the result showed that the susceptibility rates of clinical isolates were all above 80%. Only Klebsiella pneumoniae was fosA positive, with a positive rate of 26.7%. No correlation was found for the resistance between the antibiotic drugs tested and fosfomycin in the other bacteria, except for cefepime, levofloxacin and ciprofloxacin in Enterobacter cloacae and imipenem in K. pneumoniae. Conclusion: Our data suggest that fosfomycin may be a suitable antimicrobial agent for UTI isolates and ESBL-producing bacteria in our hospital.

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“…In a study from Southern part of India, Sahni RD and co-workers reported Fosfomycin susceptibility of 83 and 99% for E. coli and Enterococcus spp, respectively. Among these, 81% of extendedspectrum β-lactamase producing E.coli was susceptible to fosfomycin, while 75.7% of multidrug resistant were found to be susceptible to fosfomycin [20].…”

Section: Resultsmentioning

confidence: 99%

Fosfomycin: An Alternative Therapy for the Treatment of UTI Amidst Escalating Antimicrobial Resistance

Sabharwal

Sharma

2015

JCDR

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Evaluation of Fosfomycin Activity Against Uropathogens in a Fosfomycin-Naive Population in South India: a Prospective Study

Abstract: Fosfomycin exhibits good in vitro activity against both the uropathogens tested. Therefore, it might be considered as a treatment option for urinary tract infections in India; however, clinical trials should first reinforce the in vitro findings.

Cited by 34 publications

References 19 publications

Prevalence of 16S rRNA methylase genes among β-lactamase-producing Enterobacteriaceae clinical isolates in Saudi Arabia

Prevalence of 16S rRNA methylase genes among β-lactamase-producing Enterobacteriaceae clinical isolates in Saudi Arabia

Antibacterial Activity of Fosfomycin against Uropathogens

Fosfomycin: An Alternative Therapy for the Treatment of UTI Amidst Escalating Antimicrobial Resistance

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