Evaluation of fontanel size variation and closure time in children followed up from birth to 24 months

Boran, Perran; Oğuz, Fatma; Furman, Andrzej; Sakarya, Sibel

doi:10.3171/2018.3.peds17675

Cited by 17 publications

(11 citation statements)

References 21 publications

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“…Based on our results, it appears that the majority of the PF in Chihuahuas occurred in similar locations to fontanelles in humans. In children, however, the fontanelles close during early childhood, the anterior fontanelle between 3 and 27 months 16,17 . The posterior fontanelle is open in only 1.5% of newborn children, and in those it closes by 2 months of age 18 .…”

Section: Discussionmentioning

confidence: 99%

“…In children, however, the fontanelles close during early childhood, the anterior fontanelle between 3 and 27 months. 16 , 17 The posterior fontanelle is open in only 1.5% of newborn children, and in those it closes by 2 months of age. 18 The paired sphenoid fontanelles close at around 3 month, and the mastoid fontanelles during the second year of life.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Persistent fontanelles in Chihuahuas. Part I. Distribution and clinical relevance

Kiviranta

Rusbridge

Lappalainen

et al. 2021

Veterinary Internal Medicne

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Background: The Chihuahua dog breed is known for frequent occurrence of a bregmatic fontanelle on the dorsal skull. A common conception is that this skull defect is a clinically irrelevant finding. No studies, however, describe its prevalence or whether it is accompanied by other persistent fontanelles (PFs). Although Chihuahuas are predisposed to Chiari-like malformation (CM) and syringomyelia (SM), it is unknown whether PFs occur more commonly in dogs with clinical signs that are caused by CM or SM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Persistent fontanelles in Chihuahuas. Part I. Distribution and clinical relevance

Kiviranta

Rusbridge

Lappalainen

et al. 2021

Veterinary Internal Medicne

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“…Studies observing calvarial CT imaging and measurements observe that the majority of the sutures close between 30 and 40 months of age while small gaps might be present at most of the sutures except the metopic throughout life ( Opperman, 2000 ; Lottering et al, 2016 ). In fact, the metopic and anterior fontanelle are suggested to fuse as early as 9 months of age ( Hugh et al, 2001 ; Boran et al, 2018 ). Due to the lack of regular CT data for the patient considered here (that clinically is unethical to perform), detail validation of our predictions is challenging while overall it appears that regardless of the rate of bone formation the overall pattern of suture closures is similar to the in vivo data.…”

Section: Discussionmentioning

confidence: 99%

Using Sensitivity Analysis to Develop a Validated Computational Model of Post-operative Calvarial Growth in Sagittal Craniosynostosis

Cross

Khonsari

Galiay

et al. 2021

Front. Cell Dev. Biol.

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Craniosynostosis is the premature fusion of one or more sutures across the calvaria, resulting in morphological and health complications that require invasive corrective surgery. Finite element (FE) method is a powerful tool that can aid with preoperative planning and post-operative predictions of craniosynostosis outcomes. However, input factors can influence the prediction of skull growth and the pressure on the growing brain using this approach. Therefore, the aim of this study was to carry out a series of sensitivity studies to understand the effect of various input parameters on predicting the skull morphology of a sagittal synostosis patient post-operatively. Preoperative CT images of a 4-month old patient were used to develop a 3D model of the skull, in which calvarial bones, sutures, cerebrospinal fluid (CSF), and brain were segmented. Calvarial reconstructive surgery was virtually modeled and two intracranial content scenarios labeled “CSF present” and “CSF absent,” were then developed. FE method was used to predict the calvarial morphology up to 76 months of age with intracranial volume-bone contact parameters being established across the models. Sensitivity tests with regards to the choice of material properties, methods of simulating bone formation and the rate of bone formation across the sutures were undertaken. Results were compared to the in vivo data from the same patient. Sensitivity tests to the choice of various material properties highlighted that the defined elastic modulus for the craniotomies appears to have the greatest influence on the predicted overall skull morphology. The bone formation modeling approach across the sutures/craniotomies had a considerable impact on the level of contact pressure across the brain with minimum impact on the overall predicated morphology of the skull. Including the effect of CSF (based on the approach adopted here) displayed only a slight reduction in brain pressure outcomes. The sensitivity tests performed in this study set the foundation for future comparative studies using FE method to compare outcomes of different reconstruction techniques for the management of craniosynostosis.

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“…The average of the longitudinal and transverse dimensions was recorded as the mean fontanelle size ([AB + CD]/2). Neonates with mean fontanelle size above 97 th percentile were determined as having large fontanelle ( 19 ).…”

Section: Methodsmentioning

confidence: 99%

Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study

Seymen-Karabulut¹,

Günlemez²,

Gökalp³

et al. 2021

Jcrpe

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Objective: Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to describe the characteristics of affected newborns. Methods: Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels. Results: The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median (range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence of vitamin D deficiency (<12 ng/mL) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels, iPTH levels were low or inappropriately normal in 54.2% of the patients. Conclusion: Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.

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Evaluation of fontanel size variation and closure time in children followed up from birth to 24 months

Cited by 17 publications

References 21 publications

Persistent fontanelles in Chihuahuas. Part I. Distribution and clinical relevance

Persistent fontanelles in Chihuahuas. Part I. Distribution and clinical relevance

Using Sensitivity Analysis to Develop a Validated Computational Model of Post-operative Calvarial Growth in Sagittal Craniosynostosis

Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study

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