Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor

Suliburska, Joanna; Kocyłowski, Rafał; Grzesiak, Mariusz; Gaj, Zuzanna; Chan, Benny B.; Kaisenberg, Constantin von; Lamers, Yvonne

doi:10.5114/aoms.2018.78776

Cited by 5 publications

(7 citation statements)

References 38 publications

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“…Folate-a water-soluble vitamin B found in fruits, legumes, cereals, and green leafy vegetables-is required for placental tissue growth [10] and neural tube formation [11]. More recently, its role as a methyl donor in several molecular pathways and epigenetic mechanisms has been demonstrated [12,13].…”

Section: Introductionmentioning

confidence: 99%

Dietary Folate Intake and Folic Acid Supplements among Pregnant Women from Southern Italy: Evidence from the “Mamma & Bambino” Cohort

Barchitta

Maugeri

Lio

et al. 2020

IJERPH

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Folate requirement among women who plan to become pregnant should be raised to 600 μg/day during the periconceptional period. To meet this need, several countries began to promote the use of folic acid supplements before and during pregnancy. Here, we investigated prevalence and determinants of dietary folate intake and folic acid supplement use among 397 pregnant women (aged 15–50 years old, median = 37 years old). We also investigated their effects on neonatal outcomes in a subgroup of women who completed pregnancy. For doing that, we used data from the “Mamma & Bambino” project, an ongoing mother-child cohort settled in Catania (Italy). Inadequate folate intake was evaluated using a Food Frequency Questionnaire and defined as an intake < 600 μg/day. Women were also classified as non-users (i.e., women who did not use folic acid supplements), insufficient users (i.e., women who did not take folic acid supplements as recommended), and recommended users of folic acid supplements. Neonatal outcomes of interest were preterm birth (PTB) and small for gestational age (SGA). Nearly 65% of women (n = 257) reported inadequate folate intake, while 74.8% and 22.4% were respectively classified as insufficient or recommended users of supplements. We demonstrated higher odds of inadequate folate intake among smoking women (OR = 1.457; 95%CI = 1.046–2.030; p = 0.026), those who followed dietary restrictions (OR = 2.180; 95%CI = 1.085–4.378; p = 0.029), and those with low adherence to the Mediterranean Diet (OR = 3.194; 95%CI = 1.958–5.210; p < 0.001). In a subsample of 282 women who completed pregnancy, we also noted a higher percentage of SGA among those with inadequate folate intake (p < 0.001). Among 257 women with inadequate folate intake, those with low educational level were more likely to not take folic acid supplements than their more educated counterpart (OR = 5.574; 95%CI = 1.487–21.435; p = 0.012). In a subsample of 184 women with inadequate folate intake and complete pregnancy, we observed a higher proportion of SGA newborns among women who did not take supplement before pregnancy and those who did not take at all (p = 0.009). We also noted that the proportion of PTB was higher among non-users and insufficient users of folic acid supplements, but difference was not statistically significant. Our study underlined the need for improving the adherence of pregnant women with recommendations for dietary folate intake and supplement use. Although we proposed a protective effect of folic acid supplement use on risk of SGA, further research is encouraged to corroborate our findings and to investigate other factors involved.

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Section: Introductionmentioning

confidence: 99%

Dietary Folate Intake and Folic Acid Supplements among Pregnant Women from Southern Italy: Evidence from the “Mamma & Bambino” Cohort

Barchitta

Maugeri

Lio

et al. 2020

IJERPH

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“…The levels of study elements and folate in AF and MS in groups with abnormalities were compared with healthy deliveries as previously published [ 21 , 23 ]. The control group consisted of healthy women without birth defects or any chronic diseases such as diabetes and hypertension, not smoking, without alcohol abuse and preterm birth.…”

Section: Resultsmentioning

confidence: 99%

“…This essential mineral is necessary for the growth of the body and plays an important role in the metabolism of the fetus. Its deficiency in pregnancy may increase the risk of health disorders for both the mother and the newborn, such as mortality and morbidity, gestational diabetes, preterm labor, preeclampsia, and small for gestational age or intrauterine growth restriction [ 21 , 25 ]. It is suggested that the influence of Mg on early development relates to the TRPM7 and TRPM6 ion channels that have been implicated in the control of the homeostasis of Mg ions.…”

Section: Discussionmentioning

confidence: 99%

“…Folate analysis in AF and MS was performed according to the method described in our previous article [ 21 ]. We used chloramphenicol-resistant Lactobacillus casei as the test microorganism.…”

Section: Methodsmentioning

confidence: 99%

“… Note: Min, minimum value; max, maximum value; SD, standard deviation. * p = 0.04 significant differences vs. healthy women [ 21 ]. …”

Section: Figurementioning

confidence: 99%

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Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities

et al. 2019

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Congenital birth defects may result in a critical condition affecting the baby, including severe fetal/neonatal handicap and mortality. Several studies have shown that genetic, nutritional, and environmental factors may have an impact on fetal development and neonatal health. The relevance of essential and toxic elements on fetal development has not yet been fully investigated, and the results of recent research indicate that these elements may be crucial in the assessment of the risk of malformations in neonates. We determined the association between essential and toxic elements and the level of folate in maternal serum (MS) and amniotic fluid (AF), along with neonatal abnormalities. A total of 258 pregnant Polish women in the age group of 17–42 years participated in this study. AF and MS were collected during vaginal delivery or during cesarean section. An inductively coupled plasma mass spectrometry technique was used to determine the levels of various elements in AF and MS. The results of this exploratory study indicate that the levels of essential and toxic elements are associated with fetal and newborn anatomical abnormalities and growth disorders.

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Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

Fragoso-Bargas

Page

Joubert

et al. 2022

Preprint

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AimTo perform an epigenome-wide association study (EWAS) of serum folate in maternal blood.MethodsWe performed cross-ancestry (Europeans=302, South Asians=161) and ancestry-specific EWAS in the EPIPREG cohort, followed by methyl quantitative trait loci (mQTL) analysis and association with cardiometabolic phenotypes. We attempted replication using folate intake estimated from a food frequency questionnaire and maternal blood methylation data from MoBa, and in a previous published EWAS of maternal serum folate in cord blood.Resultscg19888088 (cross-ancestry) inEBF3, cg01952260 (Europeans), and cg07077240 (South Asians) inHERC3were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants inCASC15. The findings were not replicated in the independent samples.ConclusionSerum folate was associated with methylation at three CpG sites.

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Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor

Cited by 5 publications

References 38 publications

Dietary Folate Intake and Folic Acid Supplements among Pregnant Women from Southern Italy: Evidence from the “Mamma & Bambino” Cohort

Dietary Folate Intake and Folic Acid Supplements among Pregnant Women from Southern Italy: Evidence from the “Mamma & Bambino” Cohort

Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities

Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

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