Evaluation of focused ultrasound algorithms: Issues for reducing pre-focal heating and treatment time

Yiannakou, Marinos; Trimikliniotis, Michael; Yiallouras, Christos; Damianou, Christakis

doi:10.1016/j.ultras.2015.10.007

Cited by 15 publications

(13 citation statements)

References 24 publications

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“…Figure 10 shows a T2‐weighted fast spin echo MR image of the transducer of the positioning device and the agar phantom that was used to produce MR thermometry. No MRI compatibility evaluation was performed, since the same motors and encoders were used in previous studies by our group 23,27,28,29 . Note the excellent contrast between water, the agar‐based phantom, and the transducer.…”

Section: Resultsmentioning

confidence: 99%

“…An application was developed using the C# programming language (Visual Studio 2010 Express; Microsoft Corporation, Redmond, WA), which aimed to enhance the user interface. The two motion axes of the device are controlled by selecting an automated algorithm 23 or by specifying a direction and step to move. The software includes additional functions, such as an interface with the MRI, magnetic resonance (MR) thermometry, and US control (eg, frequency, power, and sonication time).…”

Section: Methodsmentioning

confidence: 99%

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Magnetic Resonance Imaging–Guided Focused Ultrasound Positioning System for Preclinical Studies in Small Animals

Drakos

Giannakou

Menikou

et al. 2020

J of Ultrasound Medicine

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Objectives A positioning device compatible with magnetic resonance imaging (MRI) used for preclinical studies in small animals was developed that fits in MRI scanners up to 7 T. The positioning device was designed with two computer‐controlled linear stages. Methods The positioning device was evaluated in an agar‐based phantom, which mimics soft tissues, and in a rabbit. Experiments with this positioning device were performed in an MRI system using the agar‐based phantom. The transducer used had a diameter of 50 mm, operated at 0.5 MHz, and focused energy at 60 mm. Results Magnetic resonance thermometry was used to assess the functionality of the device, which showed adequate deposition of thermal energy and sufficient positional accuracy in all axes. Conclusions The proposed system fits in MRI scanners up to 7 T. Because of the size of the positioning device, at the moment, it can be used to perform preclinical studies on small animals such as mice, rats, and rabbits.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Magnetic Resonance Imaging–Guided Focused Ultrasound Positioning System for Preclinical Studies in Small Animals

Drakos

Giannakou

Menikou

et al. 2020

J of Ultrasound Medicine

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“…The software controls the motion of the positioning device and has the following functionalities: (a) Interfacing with MRI and (b) automatic or manual motion of the two axes. Automatic motion is achieved by six different algorithms 18 . (c) MR thermometry and (d) ultrasound control (frequency, power, sonication time, duty factor and pulse duration).…”

Section: Methodsmentioning

confidence: 99%

Focused ultrasound robotic system for very small bore magnetic resonance imaging

Damianou

Giannakou

Evripidou

et al. 2020

Robotics Computer Surgery

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Background: A magnetic resonance imaging (MRI) compatible robotic system for focused ultrasound was developed for small animal like mice or rats that fits into a 9.4 T MRI scanner (Bruker Biospec 9420, Bruker Biospin, Ettlingen, Germany). The robotic system includes two computer-controlled linear stages. Materials and Methods: The robotic system was evaluated in a mouse-shaped, realsize agar-based mimicking material, which has similar acoustical properties as soft tissues. The agar content was 6% weight per volume (w/v), 4% w/v silica while the rest was degassed water. The transducer used has a diameter of 4 cm, operates with 2.6 MHz and focuses energy at 5 cm. Results: The MRI compatibility of the robotic system was evaluated in a 9.4 T small animal scanner. The efficacy of the ultrasonic transducer was evaluated in the mimicking material using temperature measurements. Conclusions: The proposed robotic system can be utilized in a 9.4 T small animal MRI scanner. The proposed system is functional, compact and simple thus providing a useful tool for preclinical research in mice and rats.

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“…In future therapies, the user will position the angular axis appropriately using manual mode; then, based on the radius of curvature of the FUS transducer and target plane, one of the other three axes will be positioned manually (e.g. the Z axis), then ablation will be initiated in the X–Y plane using one of the six algorithms created for this type of robot . (c) History (functions activated).…”

Section: Methodsmentioning

confidence: 99%

MRI-guided focused ultrasound robotic system for the treatment of bone cancer

Menikou

Yiallouras

Yiannakou

et al. 2016

Int J Med Robotics Comput Assist Surg

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Evaluation of focused ultrasound algorithms: Issues for reducing pre-focal heating and treatment time

Cited by 15 publications

References 24 publications

Magnetic Resonance Imaging–Guided Focused Ultrasound Positioning System for Preclinical Studies in Small Animals

Magnetic Resonance Imaging–Guided Focused Ultrasound Positioning System for Preclinical Studies in Small Animals

Focused ultrasound robotic system for very small bore magnetic resonance imaging

MRI-guided focused ultrasound robotic system for the treatment of bone cancer

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