Evaluation of Fluorodeoxyglucose Positron Emission Tomography in the Detection of Axillary Lymph Node Metastases in Patients With Early-Stage Breast Cancer

Barranger, Emmanuel; Grahek, D.; Antoine, Martine; Montravers, F.; Talbot, Jean-Noël; Uzan, Serge

doi:10.1245/aso.2003.12.019

Cited by 78 publications

(45 citation statements)

References 21 publications

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“…There were seven studies assessing PET/CT [73][74][75][76][77][78][79] and 19 studies assessing PET alone. 44,[80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97] Eight PET studies used ALND as the reference standard for all patients, 44,73,77,84,87,89,92,95,[98][99][100][101] 12 studies used a mixture of ALND and SLNB, [74][75][76][78][79][80][81][82][83]86,88,91,[102]…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Fourteen studies presented data such that the patients analysed in this review were entirely early stage (stage I, II or IIIA), newly diagnosed and non-DCIS, 44,75,76,80,[83][84][85][86][87][88][89]92,94,97 while the remaining 12 studies comprised up to 20% of patients who did not meet these criteria. 73,74,[77][78][79]81,82,90,91,93,95,96 Eight studies consisted entirely of patients who were clinically node negative, 73,76,79,81,83,84,87,88 13 studies included a mixture of node-negative and node-positive patients, 44,74,77,78,80,85,86,[91][92][93][94]96,97 and in five studies nodal status was not reported. 75,...…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The index test was often interpreted blind to other clinical data in addition to the reference standard, possibly to ensure a robust evaluation of PET; however, as this is likely to differ from expected clinical practice, studies where this occurred were scored negatively for the 'relevant clinical information' item. Uninterpretable results were dealt with well in only eight studies, 75,77,79,80,[86][87][88]92 and were not discussed in 16 cases. 73,74,76,78,[81][82][83][84][85]87,[89][90][91]93,94,96 Similarly, blinding of the reference standard results was under-reported, with 20 studies scoring 'unclear' .…”

Section: Magnetic Resonance Imaging Studiesmentioning

confidence: 99%

“…The reference standard was adequate in nearly all cases, with only three studies failing to give sufficient detail, 85,90,93 and two not performing ALND on those patients with large or locally advanced disease. 94,96 The delay between reference standard and index test was acceptable in 14 studies 44,76,78,79,[83][84][85][86][87][88]91,92,94,95 and not reported in 12. [73][74][75]77,[80][81][82]87,89,90,93,96 Where patients were given a different reference standard depending on the index test results (six studies), 75,76,78,79,81,83 this was either ALND or SLNB.…”

Section: Magnetic Resonance Imaging Studiesmentioning

confidence: 99%

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Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation

Cooper

Meng²,

Harnan³

et al. 2011

Health Technol Assess

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An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research a...

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Magnetic Resonance Imaging Studiesmentioning

confidence: 99%

Section: Magnetic Resonance Imaging Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation

Cooper

Meng²,

Harnan³

et al. 2011

Health Technol Assess

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“…To assess the ability of 18 F-FDG PET to determine axillary lymph node metastasis in patients with breast cancer who undergo SLNB, Barranger et al [16] recruited 32 breast cancer patients with clinically negative axillary nodes. All of the patients underwent 18 F-FDG PET, SLNB, and complete ordinal ALND.…”

Section: Comparison Of 18 F-fdg Pet (Pet/ct) and Slnb For Detecting Rmentioning

confidence: 99%

Comparison between 18F-FDG PET (PET/CT) and sentinel lymph node biopsy in the detection of regional lymph node metastasis of various malignancies: review of the literature

Qiu

Chen²

2013

JBGC

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This article reviewed comparative studies of the use of 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) or positron emission tomography/computed tomography (PET/CT) and sentinel lymph node biopsy (SLNB) for the detection of regional lymph node metastasis in patients with various malignancies. We sought to evaluate the diagnostic accuracy of 18 F-FDG PET (PET/CT) compared with SLNB to determine the presence or absence of regional lymph node metastasis. In this paper, we review 15 comparative studies of breast tumors and 17 comparative studies of melanomas that used these methods to detect regional lymph node metastasis. Original articles for other malignancies, including oral and oropharyngeal carcinoma, penile carcinoma, anal cancer, and cervical cancer, are relatively scarce. A consensus has been reached in the literature that SLNB is much more sensitive than 18 F-FDG PET and PET/CT for detecting small lymph node metastasis. 18 F-FDG PET and PET/CT cannot replace SLNB for the evaluation of early-stage regional lymphatic tumor dissemination in this patient population.

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Preoperative FDG-PET for Axillary Metastases in Patients With Breast Cancer

et al. 2006

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Intervention: Whole-body FDG-PET performed before axillary surgery and interpreted blindly. Main Outcome Measures: Axillary FDG activity, quantified by standardized uptake value (SUV); axillary metastases, quantified histologically; and tumor characteristics. Results: There was PET activity in 32 axillae (59%). The SUVs ranged from 0.7 to 11.0. Twenty tumors had an SUV of 2.3 or greater, and 34 had an SUV of less than 2.3. There were no significant differences between these 2 groups except in axillary metastasis size (SUV Յ2.2 vs SUV Ն2.3): mean age, 53 vs 58 years (P=.90); mean modified Bloom-Richardson score, 7.7 vs 7.6 (P=.20); lymphovascular invasion present, 25% vs 36% (P =.40); mean Ki-67 level, 25% vs 32% (P = .20); mean tumor size, 2.9 vs 3.2 cm (P=.05); and axillary metastasis size, 0.9 vs 1.7 (P=.001). By adopting an SUV threshold of 2.3, FDG-PET had a sensitivity of 60%, a specificity of 100%, and a positive predictive value of 100%. Conclusions: Patients with an SUV greater than 2.3 had axillary metastases. This finding obviates the need for sentinel lymph node biopsy or needle biopsy to diagnose axillary involvement. Surgeons can proceed to axillary node dissection to assess the number of nodes involved, eliminate axillary disease, or perhaps provide a survival benefit if preoperative FDG-PET has an SUV greater than 2.3.

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Evaluation of Fluorodeoxyglucose Positron Emission Tomography in the Detection of Axillary Lymph Node Metastases in Patients With Early-Stage Breast Cancer

Cited by 78 publications

References 21 publications

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation

Positron emission tomography (PET) and magnetic resonance imaging (MRI) for the assessment of axillary lymph node metastases in early breast cancer: systematic review and economic evaluation

Comparison between 18F-FDG PET (PET/CT) and sentinel lymph node biopsy in the detection of regional lymph node metastasis of various malignancies: review of the literature

Preoperative FDG-PET for Axillary Metastases in Patients With Breast Cancer

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