“…Animal studies have suggested that there is excellent penetration of drug into most tissues (5, 18, 30-34, 41, 49, 53), but only limited information on tissue penetration of fleroxacin in humans is available (22,26,41,44,53). Initial clinical experience in the treatment of sexually transmitted diseases, urinary tract infection, skin and soft tissue infections, gastrointestinal infection, and even acute exacerbations of chronic bronchitis has been quite promising, with 74 to 100% bacteriological cure rates and a tolerability comparable to those for other drugs of this class (3,12,27,35,38,42,43,45,47). However, to optimize the clinical use of * Corresponding author.…”