Evaluation of five immunoassays and one lateral flow immunochromatography for anti-SARS-CoV-2 antibodies detection

Breva, Silvia Montolio; Clavero, Carmen Molina; F, Bertomeu; Picó-Plana, Ester; Orus, Núria Serrat; Sánchez, Inmaculada Palau; Mestre-Prad, Maria Teresa; Sans-Mateu, Maria Teresa

doi:10.1016/j.eimce.2020.12.007

Cited by 2 publications

(1 citation statement)

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“…where baseline transmission rates (β 0 1 , β 0 2 , β 0 3 , β 0 4 , and β 0 5 ) represent the transmission rates when the viral and bacterial load are extremely low and not detectable by the Reverse Transcription Polymerase Chain Reaction known as RT-PCR which is used for SARS-CoV-2 detection [11] and Polymerase Chain and PCR [55]. However, even at this early stage, some transmission can still occur, although at a low level [76].…”

Section: 3mentioning

confidence: 99%

Multiscale modeling approach to assess the impact of antibiotic treatment for COVID-19 on MRSA transmission and alternative immunotherapy treatment options

Faniran,

Adewole,

Chirouze

et al. 2023

Math Appl Sci Eng

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Methicillin-Resistant Staphylococcus Aureus (MRSA) infection can occur alongside or following COVID-19, which is a concern in healthcare settings. The effectiveness of antiviral treatments for COVID-19 depends on a functioning immune response, but antibiotics used for bacterial infections like MRSA can disrupt the immune response and reduce the effectiveness of antiviral treatments. The emergence of MRSA due to excessive antibiotic usage has led to the widespread use of vancomycin as an alternative treatment. Immunomodulatory antibiotics like azithromycin may also be considered. To study the dynamics of these coinfections, a multiscale model was developed. Parameter estimation and sensitivity analysis were performed, revealing influential parameters affecting the reproduction number. Numerical simulations showed that methicillin may increase the population of co-infected cells, while azithromycin can improve the host immune response but has limited impact on MRSA proliferation. Increased efficacy of vancomycin can lead to MRSA eradication. Combination of immunomodulatory antibiotics and vancomycin has minimal effect on co-infected cell population, but increased vancomycin efficacy can reduce coinfection severity. This study emphasizes the importance of continuous research, surveillance, and the development of effective strategies to combat the complexities of COVID-19 and MRSA coinfection.

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Section: 3mentioning

confidence: 99%