Introduction: The TMJ can be affected by end-stage pathologies, such as arthritic disease, trauma, and ankylosis. The main debilitating symptoms result in limited mouth opening and pain. The TMJ prosthesis is indicated for a disease that results in anatomical modification and aims to restore joint function with pain relief. There are two types of prefabricated (stock) and custom computer-aided design/computer-aided manufacturing (CAD/CAM) system devices. Objective: It was to demonstrate through a systematic review whether the customized temporomandibular joint prosthesis has more advantages than the prefabricated prosthesis. Methods: The research was carried out from June to September 2022, using scientific articles from 2013 to 2022. The quality of the studies was based on the GRADE instrument and the risk of bias by the instrument Cochrane (Funnel Plot). Results: It was found 158 studies that underwent eligibility analysis. Conclusion: In general, both TMJ and custom implants work well. However, the added advantages of customized prostheses, along with increasing access to digital technology, are likely to result in customized devices dominating the market in total ATM replacement systems.