Evaluation of fipronil spot‐on in the treatment of flea allergic dermatitis in dogs

Abstract

The purpose of this study was to evaluate the effectiveness of treatment with 10 per cent fipronil solution for controlling signs of flea allergic dermatitis in dogs under field conditions. Thirty-one client-owned dogs with flea allergic dermatitis were treated with three monthly applications of 10 per cent fipronil solution. Flea counts and pruritus were significantly reduced at all post-treatment visits. At the final visit, on day 90, flea counts were reduced by 98 per cent, and pruritus was reduced or eliminated in 84 per cent of the study dogs. Dermatological lesion scores for erythema, crusts, scales and papules were also significantly improved by the final visit. The overall assessment of efficacy on day 90 was 'excellent' to 'good' for 87 per cent of the study dogs. The results demonstrate that treatment with monthly topical applications of 10 per cent fipronil solution is effective in reducing the prevalence and severity of signs of flea allergic dermatitis in dogs.

A randomized, blinded, controlled USA field study to assess the use of fluralaner tablets in controlling canine flea infestations

“…The following signs of FAD were separately graded by a masked veterinarian (No Sign, Mild, Moderate, or Severe): erythema [10, 11], alopecia [11], papules [10, 11], scales [10], crusts [10] and excoriations [11]. When present (i.e., Mild, Moderate, or Severe), each sign was further assessed by the masked veterinarian concerning anatomic location and whether or not the sign was indicative of FAD.…”

Efficacy of Cefpodoxime with Clavulanic Acid in the Treatment of Recurrent Pyoderma in Dogs

“…Ticks and lice were treated with ivermectin at 200  μ g/kg body weight, subcutaneously once, followed by external application of cypermethrin once a week to prevent recurrence of external parasitic infestation. Flea infestation was treated with fipronil spray twice a month [10]. Hypothyroidism was treated with oral Levothyroxine sodium at 20  μ g/kg body weight twice a day.…”

Epidemiological survey of anti-flea IgE in dogs in Japan by using an antigen-specific IgE quantitative measurement method

“…Flea bites may induce pruritus and the major pathogenic effect is flea allergic dermatitis (FAD). FAD prevention is based on the control of the flea infestation, involving regular and continued use of anti-flea drugs, which are usually topical formulations but can also be given orally (Beugnet & Franc, 2010; Farkas et al , 2009; Masuda et al , 2002; Medleau et al , 2003). No reports on epidemiological surveys regarding flea infestations in dogs in Japan have been published.…”

“…Cat flea salivary extracts also show great antigenic diversity recognized by IgE from artificially sensitized dogs or from those with FAD (Lee et al , 1999). McDermott et al cloned a major 18-kD allergen, called Cte f 1 in the international nomenclature (Medleau et al , 2003). Its structure is very similar to that of the original molecule in terms of flea IgE-binding (Medleau et al , 2003).…”

“…McDermott et al cloned a major 18-kD allergen, called Cte f 1 in the international nomenclature (Medleau et al , 2003). Its structure is very similar to that of the original molecule in terms of flea IgE-binding (Medleau et al , 2003). …”