Evaluation of fibromyalgia syndrome in patients with rosacea

Abstract

Objectives: This study aims to investigate the frequency of fibromyalgia syndrome (FMS) in rosacea patients and the relationship between disease disability score of FMS and quality of life score of rosacea. Patients and methods: This cross-sectional controlled clinical trial was performed between December 2017 and December 2018. One hundred female rosacea patients (mean age 43.2±10.1; range, 21 to 65 years) and 100 age-and sex-matched control subjects (mean age 41.2±11.1; range, 22 to 68 years) with no history of skin disease and systemic diseases including diabetes, cardiovascular, renal and hepatic diseases were recruited. Dermatology Life Quality Index (DLQI) scores were calculated using a 10-item self-administered questionnaire. The diagnosis of FMS was established according to 2010 American College of Rheumatology diagnostic criteria. Fibromyalgia Impact Questionnaire (FIQ) was used to determine the clinical severity and functional disability, while Visual Analog Scale (VAS) was used to determine pain severity in the patients with FMS. Results: The frequency of FMS in patient group was significantly higher than control group (p=0.019). The mean duration of FMS in patient group was significantly higher than control group (p=0.001). There was no significant difference in terms of the age of onset of FMS, FIQ and VAS scores between groups (p=0.53, p=0.54, p=0.07, respectively). DLQI scores were significantly correlated with FIQ scores in the patient group (r=0.43, p=0.008). Conclusion:The frequency of FMS in rosacea patients was significantly higher than control subjects without any skin disease and there was a correlation between disability score of FMS and quality of life score of rosacea. Investigating fibromyalgia symptoms in rosacea patients may be helpful for providing patient-based therapeutic approaches where neurologically based treatments may also be beneficial for rosacea.

Quality of life measurement in rosacea. Position statement of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

“…From the 207 articles identified in the literature search, 139 were excluded based on the exclusion criteria, leaving 68 publications 20–87 for the further analysis.…”

“…Another generic HRQoL instrument EuroQoL (EQ)‐5D 55,67 and its modifications EQ‐5D‐3L 76 and EQ‐5D‐visual analogue scale 77 were also used to assess quimp in rosacea. The dermatology‐specific Dermatology Life Quality Index (DLQI) was used for quimp assessment in 45 studies on rosacea 20–23,25,28–30,32,34,35,37,40–42,46,48–57,60,62–69,72–74,77,78,80,82,83,86,87 . Data on the DLQI scores from included articles is given in Figure 1.…”

“…26 Comorbidities DLQI scores were significantly correlated with Fibromyalgia Impact Questionnaire scores in the patients with rosacea. 80 Significantly higher DLQI, anxiety and depression scores were observed in the rosacea group compared to the control group. The total DLQI score of patients was positively related to anxiety and depression scores in the Hospital Anxiety and Depression Scale.…”

The Legitimacy of the Extension of State Sovereignty in the Airspace in International Law

“…Sözleşmeye taraf devletler ayrıca, ulusal egemenlik altında bulunan hava sahalarında, "yabancı ülke gemilerine karasularında tanınan zararsız geçiş hakkına benzer bir hakkı, barış zamanında diğer taraf devletlerin uçaklarına ayrım gözetmeksizin" tanıyacakları ifade edilebilir 58 . Devletin egemenliğini idame ettirdiği hava sahasında mutlak ve münhasır yetkiye sahip olmasının sonuçlarından biri, ulusal hava sahasına yabancı olarak addedilen hava araçlarının girişinin devletin iznine tabi olmasıdır 59 . Bir diğer sonucu ise, devlet kendi hava sahası içerisinde tüm ulusal yasalarını kural olarak herkese karşı ileri sürme ve uygulama yetkisine sahip olmasıdır 60 .…”

“…Devletin egemenliğini idame ettirdiği hava sahasında mutlak ve münhasır yetkiye sahip olmasının sonuçlarından biri, ulusal hava sahasına yabancı olarak addedilen hava araçlarının girişinin devletin iznine tabi olmasıdır 59 . Bir diğer sonucu ise, devlet kendi hava sahası içerisinde tüm ulusal yasalarını kural olarak herkese karşı ileri sürme ve uygulama yetkisine sahip olmasıdır 60 .…”