Evaluation of Fetal Serum Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Fetal Distress

Erol, Seyit Ahmet; Altınboğa, Orhan; Öztürk, Filiz Halıcı; Özgü, Burçin Salman; Taşçı, Yasemin; Neşeli̇oğlu, Salim; Erel, Özcan; Şahın, Dilek

doi:10.1080/15513815.2020.1831662

Cited by 9 publications

(5 citation statements)

References 31 publications

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“…These investigations specifically focused on examining thiol-disulfide dynamics in pregnant women. Based on the findings of previous research and the outcomes of our present investigation, it can be stated that the practice of fasting among pregnant women leads to a change in thioldisulfide hemostasis towards an oxidant state (25)(26)(27)(28)(29)(30)(31)(32). It can be said that pregnant women should not fast in order not to be exposed to oxidative stress during Ramadan and postpone it until after birth and even to the end of the breastfeeding period.…”

Section: Discussionsupporting

confidence: 53%

The Consequences of Fasting During Pregnancy on the Thiole/Disulfide Balance: An Observational Study

BAKİ ERİN,

ÇEBİ

2023

Medical Records

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Objective: The aim of this study was to investigate the effect of fasting on thiol-disulfide hemostasis in healthy pregnant women. Methods: The study, conducted during Ramadan in 2021, included a control group of 53 pregnant women who were fasting and 57 pregnant women with similar demographics who were not fasting. Analyses were conducted on the disulfide, native thiol, and total thiol concentrations in plasma obtained from centrifuged and venous blood, respectively. The ratios "disulphide/thiol 100," "disulphide/total thiol 100," and "thiol/total thiol 100" were all calculated. Results: There were 32 pregnant women in the second trimester and 21 pregnant women in the third trimester among fasting participants, whereas there were 33 pregnant women in the second trimester and 24 pregnant women in the third trimester among non-fasting participants. Disulfide, and disulfide/nativethiol*100, disulfide/totalthiol*100, and native/totalthiol*100 ratios were not significantly different between groups. There was a statistically significant difference between the groups when the native thiol mean values and the total thiol mean values were compared. Conclusion: Thiol-Disulfide our study is the first to evaluate homeostasis in fasting pregnant women; it is the first report in this field. The investigation revealed that there had been a shift in the thiol-disulfide equilibrium in the direction of oxidation. Fasting during pregnancy is associated with an increase in oxidative stress.

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Section: Discussionsupporting

confidence: 53%

The Consequences of Fasting During Pregnancy on the Thiole/Disulfide Balance: An Observational Study

BAKİ ERİN,

ÇEBİ

2023

Medical Records

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“…The latest guidelines propose that SOD activity should be used for the characterization and quantitation of OS risk in general. More specifically, for DNA and RNA damage, 8-hydroxydeoxyguanosine (8-OHdG) is recommended; for lipid peroxidation, malondialdehyde (MDA) is recommended; and for the characterization of OS in gestational disorders nitrogen monoxide (NO), total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI) and glutathione (GSH) are recommended [19][20][21][22]. Total antioxidant capacity denotes the cumulative effect of all antioxidants present in a biological sample, whereas total oxidant status characterizes the cumulative oxidant effects in the whole organism.…”

Section: Markers Of Oxidative Stress In Obstetricsmentioning

confidence: 99%

“…Specific markers have been identified that predict outcomes in specific obstetric conditions. In pre-eclampsia and associated IUGR, the best predictors for outcomes include MDA, GSH, CA, free thiol (FT), leptin, ischemia-modified albumin (IMA) and receptor for advanced glycation end products (sRAGE) [20][21][22][23][24][25][26]. In gestational diabetes, MDA (malondialdehyde), TAC, GSH, CAT and NO have been recommended as specific predictors [19,[27][28][29].…”

Section: Markers Of Oxidative Stress In Obstetricsmentioning

confidence: 99%

“…Quantitative Markers of Oxidative Stress pre-eclampsia + IUGR MDA, GSH, CAT, FT leptin, IMA, sRAGE [20][21][22][23][24][25] gestational diabetes MDA, TAC, GSH, CAT, NO [19,[27][28][29] premature delivery 8-OHdG, GPx, CAT, NO, TAC, TOS, OSI [30][31][32][33]36,37] 8-OHdG: 8-hydroxydeoxyguanosine; CAT: catalase; FT: free-thiol; GPx: glutathione peroxidase; GSH: glutathione; IMA: ischemia-modified albumin; IUGR: intrauterine growth restriction; MDA: malondialdehyde; NO: nitric oxide; OSI: oxidative stress index; sRAGE: soluble receptor for advanced glycation end products; TAC: total antioxidant capacity; TOS: total oxidant status.…”

Section: Conditionmentioning

confidence: 99%

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Disrupted Balance of the Oxidant–Antioxidant System in the Pathophysiology of Female Reproduction: Oxidative Stress and Adverse Pregnancy Outcomes

Joó,

Sulyok,

Bódis

et al. 2023

CIMB

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The significance of oxidative stress in the pathophysiology of male reproductive processes has been closely studied in the last two decades. Recently, it has become clear that oxidative stress can lead to numerous pathological conditions during female reproductive processes as well, contributing to the development of endometriosis, polycystic ovary syndrome and various forms of infertility. During pregnancy, physiological generation of reactive oxygen species (ROS) occurs in association with several developmental processes including oocyte maturation and implantation. An overproduction of ROS can lead to disturbances in fetal development and increases the risk for missed abortion, intrauterine growth restriction, pre-eclampsia, premature delivery and gestational diabetes. Our review focuses on the etiological role of the disrupted oxidant–antioxidant system during human gestation as it relates to adverse pregnancy outcomes.

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“…10 During the foetal distress pathogenesis, increased ischemic modified albumin levels maybe the best indicator of an underlying non -acute ischemic condition. 11 Hypoxia during intrapartum causes difficulties in nearly 1% of labours and results in mortality in almost 0.5 in 1000 pregnancies as well as cerebral palsy, a long-term neurological sequelae of intrapartum hypoxia, in a similar number of pregnancies. 12 For the obstetric anaesthetist, emergency caesarean deliveries for foetal distress can be challenging given the limited time, the increased threat to the foetus and the well-being of the mother.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Review of Decision to Delivery Time Interval for Foetal Distress at a Central Hospital

Khumalo¹,

Leonard²,

Scribante³

et al. 2022

IJWH

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Purpose The aim of this study was to describe the trajectory of emergency caesarean deliveries for foetal distress at Chris Hani Baragwanath Academic Hospital (CHBAH). Patients and Methods A retrospective, contextual, descriptive study, using consecutive convenience sampling was done reviewing all the records of emergency caesarean deliveries for foetal distress at CHBAH in February 2019 until a minimum sample size of 385 was reached. Results During the study period, a total of 617 caesarean deliveries were done, of which 572 (92.7%) were emergencies. Foetal distress accounted for 395 (69.1%) of the emergency caesarean deliveries. No emergency caesarean delivery for foetal distress conformed to the 30-minute DDI and the mean (SD) DDI was 411 (291) minutes. The mean (SD) 5-minute and 10-minute Apgar scores were 8.4 (1.6) and 9.6 (1.3), respectively. There was a significant difference between the type of anaesthetic (general or neuraxial), with those receiving general anaesthesia having shorter anaesthetic start to cut time (p=0.0110). However, those delivered following neuraxial anaesthesia had better 5-minute (p=0.0002) and 10-minute (p=0.0175) Apgar scores. Conclusion This study showed that a DDI of 30-minutes, was not achieved at CHBAH during the study period. Most babies diagnosed with foetal distress pre-delivery had 5-minute and 10-minute Apgar scores inconsistent with this diagnosis. This over-diagnosis of foetal distress in some cases could have led to delays in delivery of babies who had actual foetal distress and where a 30-minute DDI could have improved outcome.

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Evaluation of Fetal Serum Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Fetal Distress

Cited by 9 publications

References 31 publications

The Consequences of Fasting During Pregnancy on the Thiole/Disulfide Balance: An Observational Study

The Consequences of Fasting During Pregnancy on the Thiole/Disulfide Balance: An Observational Study

Disrupted Balance of the Oxidant–Antioxidant System in the Pathophysiology of Female Reproduction: Oxidative Stress and Adverse Pregnancy Outcomes

A Retrospective Review of Decision to Delivery Time Interval for Foetal Distress at a Central Hospital

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