Evaluation of fetal cardiac morphology and functions in pregnant women with familial Mediterranean fever

Oluklu, Deniz; Kara, Özgür; Turgut, Ezgi; Ayhan, Şule Göncü; Yıldırım, Muradiye; Şahın, Dilek

doi:10.1111/echo.15336

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…Maternal inflammatory processes may have effects on the fetal circulatory system. In a previous study, cardiac diastolic functions changed in fetuses with maternal familial Mediterranean fever compared to healthy fetuses, and fetal cardiac systolic functions changed as the duration of maternal disease increased 15 . In a study that included 55 SARS‐CoV‐2 infected pregnant women, fetal pulmonary artery AT and AT/ET ratio were lower in the group admitted to NICU 16 .…”

Section: Discussionmentioning

confidence: 80%

“…In a previous study, cardiac diastolic functions changed in fetuses with maternal familial Mediterranean fever compared to healthy fetuses, and fetal cardiac systolic functions changed as the duration of maternal disease increased. 15 In a study that included 55 SARS-CoV-2 infected pregnant women, fetal pulmonary artery AT and AT/ET ratio were lower in the group admitted to NICU. 16 In addition, in another study that included 41 pregnant women who recovered from COVID-19, fetal AT and AT/ET ratio values were significantly lower than healthy fetuses.…”

Section: Discussionmentioning

confidence: 93%

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Effect of maternal autoimmune diseases on fetal pulmonary artery Doppler indices: A case–control study

et al. 2023

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Objective To compare the fetal pulmonary artery Doppler indices of pregnant women with autoimmune diseases such as systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and antiphospholipid syndrome (APS) with healthy pregnant women. Methods Thirty‐nine pregnancies were included in the case group, 19 of them SLE, 12 with SS, and eight with APS. The gestational age‐matched 54 healthy pregnant women were included in the control group. Peak systolic velocity, time‐averaged velocity, systolic/diastolic ratio, pulsatility index, resistance index, acceleration time (AT), ejection time (ET), and AT/ET ratio were obtained from pulmonary artery waveform by using spectral Doppler ultrasound. Results Significantly shorter AT and lower AT/ET ratio were detected in the case group (p = < .001, p = < .001, respectively). The shortening of AT and decreasing of the AT/ET ratio were more predominant in the APS group. However, there was no significant difference between the SLE, SS, and APS groups in fetal pulmonary artery Doppler indices. Also, a moderate correlation was found between maternal disease duration (years) and fetal pulmonary artery AT (r = −.516, p = .001) and AT/ET ratio (r = −.558, p = < .001). Conclusion Fetal pulmonary artery Doppler indices may be affected in maternal autoimmune diseases. Further studies are needed to evaluate fetal pulmonary Doppler indices such as AT and AT/ET ratio to predict neonatal respiratory morbidity and lung maturation in pregnant women with SLE, SS, and APS.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 93%

Effect of maternal autoimmune diseases on fetal pulmonary artery Doppler indices: A case–control study

et al. 2023

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“…As the duration of maternal FMF increases, systolic functions may also change. 14 In our study, we found that MPI and LCO parameters did not change, but E wave and E/A ratio values were lower in the asthma group. We also found a prolongation of IVRT in the asthma group.…”

Section: Discussionmentioning

confidence: 38%

“…14 Control cases were planned as 60 participants as well.The Kolmogorov-Smirnov test was used whether the variables were normally distributed or not. Because the variables were normally distributed, descriptive analyses were reported as mean and standard deviation.…”

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confidence: 99%

Assessment of fetal cardiac functions in pregnant women with asthma

et al. 2023

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Aim This study aims to investigate the effects of maternal asthma on fetal cardiac functions. Methods The study was planned with 30 pregnant women who presented to a tertiary health center and were diagnosed with asthma and 60 healthy controls with similar gestational ages. The fetal echocardiographic assessment was assessed between 33 and 35 weeks of gestation with pulsed‐wave Doppler (PW), M‐mode, and tissue Doppler imaging (TDI). Fetal cardiac functions were compared between maternal asthma and the control group. Cardiac functions were assessed according to the duration of maternal asthma diagnosis, as well. Results Early diastolic function parameters, tricuspid E wave (p = .001), and tricuspid E/A ratio (p = .005) were significantly lower in the group with maternal asthma. Tricuspid annular plane systolic excursion (TAPSE) and measurements of mitral annular plane systolic excursion (MAPSE) values were statistically lower in the study group than in the control group; p = .010 and p = .012, respectively. Parameters assessed with TDI (E′, A′, S′, E/E′, and MPI′ of tricuspid valves) and global cardiac function parameters assessed with PW like myocardial performance index (MPI) and left cardiac output (LCO) were similar between groups (p > .05). Although, MPI did not change between groups, and the isovolumetric relaxation time (IVRT) value was prolonged in maternal asthma cases (p = .025). Conclusion We found that maternal asthma disease causes alteration in fetal diastolic and early systolic cardiac functions, but the global fetal cardiac function does not change. Diastolic heart function values also varied with the duration of maternal asthma. Prospective studies are needed to compare fetal cardiac functions with additional patient groups according to disease severity and type of medical treatment.

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“…The sample size was calculated using G Power software (version 3.1 Franz Foul, Kiel University). It was determined that at least 30 participants had to be included to achieve a mean effect size of 0.50 and 95% power at a significance level of < 0.05 14 . Control cases were planned as 60 participants as well.…”

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confidence: 99%

Assessment Of Fetal Cardiac Functions In Pregnant Women Wı̇th Asthma

Koç

Oluklu

Hendem

et al. 2023

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Aim:This study aims to investigate the effects of maternal asthma on fetal cardiac functions. Methods:The study was planned with 30 pregnant women who presented to a tertiary health center and were diagnosed with asthma and 60 healthy controls with similar gestational ages. The fetal echocardiographic assessment was assessed between 33 and 35 weeks of gestation with pulsed-wave Doppler (PW), M-mode, and tissue Doppler imaging (TDI). Fetal cardiac functions were compared between maternal asthma and control group. Cardiac functions were assessed according to the duration of maternal asthma diagnosis, as well. Results:Early diastolic function parameters, tricuspid E wave (p=0.001), and tricuspid E/A ratio (P=0.005) were significantly lower in the group with maternal asthma. TAPSE and MAPSE values were statistically lower in the study group than in the control group; p=0.010 and p=0.012, respectively. Parameters assessed with TDI (E’, A’, S’, E/E’, and MPI’ of tricuspid valves) and global cardiac function parameters assessed with pulsed-wave Doppler like myocardial performance index (MPI) and left cardiac output (LCO) were similar between groups (p> 0.05). Although, MPI did not change between groups, and the isovolumetric relaxation time (IVRT) value was prolonged in maternal asthma cases (p=0.025). Conclusion:We found that maternal asthma disease causes alteration in fetal diastolic and early systolic cardiac functions, but the global fetal cardiac function does not change. Diastolic heart function values also varied with the duration of maternal asthma. Prospective studies are needed to compare fetal cardiac functions with additional patient groups according to disease severity and type of medical treatment.

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Evaluation of fetal cardiac morphology and functions in pregnant women with familial Mediterranean fever

Cited by 8 publications

References 20 publications

Effect of maternal autoimmune diseases on fetal pulmonary artery Doppler indices: A case–control study

Effect of maternal autoimmune diseases on fetal pulmonary artery Doppler indices: A case–control study

Assessment of fetal cardiac functions in pregnant women with asthma

Assessment Of Fetal Cardiac Functions In Pregnant Women Wı̇th Asthma

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