Evaluation of faecal incontinence scores

Brophy, Shawn; Deasy, Joseph O.; McNamara, DA

doi:10.1055/s-2005-922899

Cited by 1 publication

(2 citation statements)

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“…In this model, it is assumed that there is no significant change in the structure of the matrix during contact with water and that the swelling of the polymer network and its dissolution are negligible. The drug is initially dispersed inside the polymer network, and then due to the difference of concentration in the release medium, it is slowly diffused and released from the carrier structure 62 . This mechanism is aligned with our observation regarding the in vitro release study, where polymer swelling did not appear at pH = 6.8 and 7.4, and the drug was released from the non‐coated CNPs at a very low rate.…”

Section: Resultssupporting

confidence: 89%

“…The drug is initially dispersed inside the polymer network, and then due to the difference of concentration in the release medium, it is slowly diffused and released from the carrier structure. 62 This mechanism is aligned with our observation regarding the in vitro release study, where polymer swelling did not appear at pH = 6.8 and 7.4, and the drug was released from the non-coated CNPs at a very low rate. Therefore, the coating of CNPs with a lipid layer further contributed to the faster diffusion of the hydrophobic Isotretinoin.…”

Section: In Vitro Drug Release Studysupporting

confidence: 90%

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Preparation a core‐shell lipid/polymer nanoparticle containing Isotretinoin drug with pH sensitive property: A response surface methodology study

Ghaghelestani

Farhadian

Binesh

2021

J of Applied Polymer Sci

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In this study, a core‐shell lipid/polymer nanoparticle (NP) was prepared to deliver Isotretinoin drug with pH sensitive and controllable drug release property for oral administration usage. Chitosan was cross‐linked to tripolyphosphate to form the core of the NP using the ionic gelation technique and coated with glycerol monostearate lipid as a shell by applying a two‐step approach. Response surface methodology was used to investigate the effects of various parameters on particle size and drug entrapment efficiency of the nanoparticles. Optimal nanoparticles with lower particle size and higher entrapment efficiency had a diameter of 100 nm based on TEM analysis and 64% drug entrapment efficiency. Coating NPs surface with lipid changed the NPs charge, hydrophilicity and swelling property. Lipid coating NPs changed release rate from 6 to 4% after 2 h in simulated gastric fluid (SGF), 9 to 16% after 6 h in simulated intestine fluid (SIF) and 21 to 71% after 7 days in blood medium. Kinetic modeling of drug release confirmed Fickian diffusion based on Higuchi model in SIF and blood media where swelling and dissolution of polymer network were negligible, while drug dissolution due to polymer swelling in SGF media was the dominant mechanism for drug release.

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Section: Resultssupporting

confidence: 89%

Section: In Vitro Drug Release Studysupporting

confidence: 90%