Evaluation of faecal calprotectin as a valuable non‐invasive marker in distinguishing gut pathogens in young children with acute gastroenteritis

Sýkora, Josef; Siala, Konrad; Huml, Michal; Varvařovská, J; Schwarz, Jaqueline; Pomahačová, Renata

doi:10.1111/j.1651-2227.2010.01843.x

Cited by 57 publications

(53 citation statements)

References 32 publications

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“…Weh et al [12] showed that C-Reactive Protein, serum Interferon gama, and the fecal proteins lactoferrin and f-CP might be useful in differentiating between bacterial and viral gastroenteritis in adults. Sykora et al published that f-CP facilitates early discrimination between bacterial and viral causes of AGE in children before the age 3 [13]. Similarly to this study, our study indicated that f-CP levels are significantly higher in patients with microscopy-positive groups in especially proven bacterial gastroenteritis, such as Salmonella and Shigella infections, but lower in patients with Rotavirus, Adenovirus, and Norovirus infections.…”

Section: Discussionsupporting

confidence: 81%

Fecal calprotectin: can be used to distinguish between bacterial and viral gastroenteritis in children?

Duman

Gençpınar

Biçmen

et al. 2015

The American Journal of Emergency Medicine

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Section: Discussionsupporting

confidence: 81%

Fecal calprotectin: can be used to distinguish between bacterial and viral gastroenteritis in children?

Duman

Gençpınar

Biçmen

et al. 2015

The American Journal of Emergency Medicine

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“…The f-CP level in C. concisus patients was significantly lower and 41 patients had normal f-CP (<50 mg/kg). This finding reflects the lower intestinal inflammation in these patients compared with C. jejuni/coli patients, and the f-CP levels in C. concisus infection could be compared with viral gastroenteritis although with a prolonged clinical outcome [5,9,10]. The authors conclude that clinicians should be aware of C. concisus infection, especially in patients with prolonged mild diarrhea, in the differential diagnosis to IBD.…”

mentioning

confidence: 74%

Evaluation of fecal calprotectin inCampylobacter concisusandCampylobacter jejuni/coligastroenteritis

Nielsen

Engberg

Ejlertsen

et al. 2013

Scandinavian Journal of Gastroenterology

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Calprotectin (CP) is a calcium-binding cytosolic neutrophil protein and the concentration in feces reflects the migration of neutrophils into the gut lumen. Testing for fecal CP (f-CP) in patients with negative cultures for enteric pathogens is widely accepted as a useful screening tool for identifying patients who are most likely to benefit from endoscopy for suspected inflammatory bowel disease (IBD) with the assumption that a negative f-CP is compatible with a functional disorder. Campylobacter concisus has recently been reported to have a high incidence in the Danish population almost equal to Campylobacter jejuni and Campylobacter coli and has been reported to cause prolonged watery diarrhea. However, isolation of C. concisus from feces requires the filter method in a hydrogen-enriched microaerobic atmosphere, which is not commonly used in the laboratory, and the diagnosis may consequently be missed. The aim of this study was to evaluate the f-CP levels, as a marker for the intestinal inflammation in C. jejuni/coli- and C. concisus-infected patients. The authors found a high concentration of f-CP (median 631: IQR 221-1274) among 140 patients with C. jejuni/coli infection, whereas the f-CP level among 99 C. concisus-infected patients was significantly lower (median 53: IQR 20-169). The data correlate to the severe inflammatory gastroenteritis seen in patients infected with C. jejuni/coli, whereas C. concisus-infected patients have a much lower intestinal inflammation which could be compared with viral gastroenteritis. Nevertheless, clinicians should be aware of C. concisus infection, especially in patients with prolonged mild diarrhea, in the differential diagnosis to IBD.

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“…It is important to remember that all evidence indicates that a raised faecal calprotectin is indicative of organic disease but has no role in the differential diagnosis of the type of disease 9. Increased faecal calprotectin concentrations have been reported in bacterial gastroenteritis in adults10 and children,11 colorectal cancer12 and diverticular disease 13…”

Section: Calprotectinmentioning

confidence: 99%

Faecal markers of gastrointestinal inflammation

Sherwood

2012

J Clin Pathol

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Gastrointestinal (GI) symptoms including abdominal pain, bloating and diarrhoea are a relatively common reason for consulting a physician. They may be due to inflammatory bowel disease (inflammatory bowel disease; Crohn's disease, ulcerative colitis and indeterminate colitis), malignancy (colorectal cancer), infectious colitis or irritable bowel syndrome (IBS). Differentiation between these involves the use of clinical, radiological, endoscopic and serological techniques, which are invasive or involve exposure to radiation. Serological markers include C-reactive protein, erythrocyte sedimentation rate and antibodies (perinuclear antineutrophil cytoplasm antibody and anti-Saccharomyces cerevisiae antibody). Faecal markers that can aid in distinguishing inflammatory disorders from non-inflammatory conditions are non-invasive and generally acceptable to the patient. As IBS accounts for up to 50% of cases presenting to the GI clinic and is a diagnosis of exclusion (Rome III criteria), any test that can reliably distinguish IBS from organic disease could speed diagnosis and reduce endoscopy waiting times. Faecal calprotectin, lactoferrin, M2-PK and S100A12 will be reviewed.

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Evaluation of faecal calprotectin as a valuable non‐invasive marker in distinguishing gut pathogens in young children with acute gastroenteritis

Abstract: f-CP facilitates early discrimination between bacterial and viral causes of AG in young children. Combining f-CP with CRP increases the diagnostic power of diagnosing BAG.

Cited by 57 publications

References 32 publications

Fecal calprotectin: can be used to distinguish between bacterial and viral gastroenteritis in children?

Fecal calprotectin: can be used to distinguish between bacterial and viral gastroenteritis in children?

Evaluation of fecal calprotectin inCampylobacter concisusandCampylobacter jejuni/coligastroenteritis

Faecal markers of gastrointestinal inflammation

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