Evaluation of factors influencing medication compliance in inpatient treatment of psychotic disorders

Janssen, Birgit; Gäebel, Wolfgang; Haerter, M.; Komaharadi, F.; Lindel, Birgit; Weinmann, Stefan

doi:10.1007/s00213-006-0413-4

Cited by 75 publications

(86 citation statements)

References 25 publications

(22 reference statements)

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“…Literature showed one of the commonest reason cited for discontinuation of medication was poor financial status. 10 But the other study showed in-spite of the…”

Section: Resultsmentioning

confidence: 90%

“…denial of illness & side effect of medications. 9 Study conducted by Janssen B et al reported that individual who switched from a typical to an atypical antipsychotic drug more compliant was observed; it may be due to lesser side effects 10 .They also revealed that perceived benefit from medication proved to be the main reason for patients compliance with neuroleptic treatment. With regards to association between level of compliance and treatment access related factors, significant association was found (P<0.05).…”

Section: Lama S Et Al May-august 2012; Vol 10 (No2);113-117mentioning

confidence: 98%

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Level of compliance and factors associated with non-compliance to treatment among the mentally ill patients

2012

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Background: Mental illnesses are treatable and need medication and other therapies i.e. counseling, psychotherapy etc for the better outcome. Poor adherence to psychiatric medication regimens is a major obstacle to the effective care of persons who have chronic mental illness. Objectives: The study aims to identify the level of compliance and factors associated with non-compliance to treatment regimen. Methods: This was a hospital based cross sectional study carried out in psychiatric ward and OPD at B.P.Koirala Institute of Health Sciences, Dharan Nepal. A total of 150 patients were included as study samples using purposive sampling technique. Data was collected using self developed, pre tested, semi structured Pro forma by interview method. Results: Half of the patients showed average compliance. Thirty seven percentages of patients had good compliance and only 13% showed poor compliance. There was no association between drug compliance and demographic variables (p> 0.05). Drug compliance was significantly associated with factors such as drug related aspects, treatment access related factors, quality of interaction with treating team, family support, attitude towards mental illness and relatives' insight towards mental illness (p<0.05 ). Conclusion: The findings of the study highlighted the various factors such as drug related, social support, and treatment access related factors are influencing the drug compliance among the mentally ill patients.

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“…Literature showed one of the commonest reason cited for discontinuation of medication was poor financial status. 10 But the other study showed in-spite of the…”

Section: Resultsmentioning

confidence: 90%

Section: Lama S Et Al May-august 2012; Vol 10 (No2);113-117mentioning

confidence: 98%

Level of compliance and factors associated with non-compliance to treatment among the mentally ill patients

2012

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“…The evidence suggests that sociodemographic factors such as gender [Acosta et al 2009;Linden et al 2001] and family/marital status [Acosta et al 2009;Linden et al 2001] do not influence adherence as the association between nonadherence and these variables were not significant in most studies. However, results were mixed concerning ethnicity [Aldebot and de Mamani, 2009;Valenstein et al 2004], level of education [Acosta et al 2009;Aldebot and de Mamani, 2009;Hudson et al 2004;Janssen et al 2006;Linden et al 2001;Loffler et al 2003] and age [Acosta et al 2009;Linden et al 2001;Valenstein et al 2004]. Lack of insight was significantly associated with nonadherence in all studies [Acosta et al 2009;Aldebot and de Mamani 2009;Loffler et al 2003;Olfson et al 2006] except one [Linden et al 2001].…”

Section: Discussionmentioning

confidence: 99%

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Higashi¹,

Medic

Littlewood

et al. 2013

Therapeutic Advances in Psychopharmacology

472

381

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Background: Nonadherence to medication is a recognized problem and may be the most challenging aspect of treatment. Methods:We performed a systematic review of factors that influence adherence and the consequences of nonadherence to the patient, healthcare system and society, in patients with schizophrenia. Particular attention was given to the effect of nonadherence on hospitalization rates, as a key driver of increased costs of care. A qualitative systematic literature review was conducted using a broad search strategy using disease and adherence terms. Due to the large number of abstracts identified, article selection was based on studies with larger sample sizes published after 2001. Thirty-seven full papers were included: 15 studies on drivers and 22 on consequences, of which 12 assessed the link between nonadherence and hospitalization. Results: Key drivers of nonadherence included lack of insight, medication beliefs and substance abuse. Key consequences of nonadherence included greater risk of relapse, hospitalization and suicide. Factors positively related to adherence were a good therapeutic relationship with physician and perception of benefits of medication. The most frequently reported driver and consequence were lack of insight and greater risk of hospitalization respectively. Conclusions: Improving adherence in schizophrenia may have a considerable positive impact on patients and society. This can be achieved by focusing on the identified multitude of factors driving nonadherence.

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“…Studies involving the conventional antipsychotics had earlier implicated the incidence of akathisia as a major determinant of treatment discontinuation. 17,46 However, with the increased use of the second-generation, atypical antipsychotics, akathisia has become less of an issue, 9,47 and indeed current thinking is that lack of efficacy, rather than tolerability profile, is a stronger predictor of early discontinuation. 7,35,[48][49][50] Medication noncompliance and undercompliance continue to be a problem in the treatment of schizophrenia; the vast majority of hospital admissions for exacerbation of psychosis have been linked to noncompliance, 6,51 which may still be the most important militating factor in relapse.…”

Section: Discussionmentioning

confidence: 99%

Patient perspectives on antipsychotic treatments and their association with clinical outcomes

Liu‐Seifert

Osuntokun²,

Godfrey³

et al. 2010

PPA

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This analysis examined patient-reported attitudes toward antipsychotic medication and the relationship of these attitudes with clinical outcomes and pharmacotherapy adherence. The analysis included three randomized, double-blind studies in patients with schizophrenia, schizoaffective disorder, or schizophreniform disorder diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders 4th Edition and randomly assigned to treatment with olanzapine 5-20 mg/day or another antipsychotic (haloperidol 2-20 mg/day, risperidone 2-10 mg/day, or ziprasidone 80-160 mg/day). Patient-reported improvements were significantly greater for olanzapine (n = 488) versus other treatments (haloperidol n = 145, risperidone n = 158, or ziprasidone n = 271) on multiple Drug Attitude Inventory items. A positive attitude toward medication reported by patients was significantly associated with greater clinical improvement on the Positive and Negative Syndrome Scale and lower discontinuation rates. These results suggest that patients' perceptions of treatment benefits are associated with objective clinical measures, including reduction of symptom severity and lower discontinuation rates. Furthermore, olanzapine may be associated with more positive treatment attitudes. These findings may contribute to a better understanding of reasons for treatment adherence from patients' own perspectives.

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Evaluation of factors influencing medication compliance in inpatient treatment of psychotic disorders

Abstract: Patient-related in addition to disease-related factors may strongly influence medication compliance. Besides more compliance with atypicals supposed by the literature, there may be a higher propensity for atypical drugs to be prescribed to those assumed to be more compliant.

Cited by 75 publications

References 25 publications

Level of compliance and factors associated with non-compliance to treatment among the mentally ill patients

Level of compliance and factors associated with non-compliance to treatment among the mentally ill patients

Medication adherence in schizophrenia: factors influencing adherence and consequences of nonadherence, a systematic literature review

Patient perspectives on antipsychotic treatments and their association with clinical outcomes

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