Evaluation of Factor VIII as a Risk Factor in Indian Patients with DVT

Abstract

Introduction. Elevated factor VIII population in the Indian population has not been studied as a possible risk factor for deep vein thrombosis (DVT). High factor VIII level is considered a predisposing factor for DVT and its recurrence. However it is known to vary between populations and its exact role in the etiopathogenesis of thrombophilia remains unknown. Material and Methods. Factor VIII levels of patients with DVT who had undergone a prothrombotic workup as a part of their workup was compared to normal age matched controls in a 1 : 3 ratio. Results. There were 75 patients with DVT who had undergone a prothrombotic workup in the course of their treatment for lower limb DVT. In these, 64% had levels of factor VIII more than 150 as compared to 63% of normal controls (p > 0.05, not significant). Conclusion. Elevated factor VIII in the Indians may not be associated with the same thrombotic risk as seen in the West. We find a variation in the levels of factor VIII with a different “normal” than what is reported in other populations. This needs further study to elucidate the role of factor VIII in the evaluation and treatment of thrombophilia.

Laboratory characterization of obligate carriers of type 3 von Willebrand disease with a potential role for Platelet Function Analyzer (PFA‐200)

“…However, there are insufficient data in comparison with Indian population. Two studies from India have shown that the mean factor VIII and VWF values are higher in blood donors in India when compared to other populations around the world 26,27 . Although the exact mechanism for this is uncertain, this could explain the higher values seen among the OCs of our study.…”

“…Two studies from India have shown that the mean factor VIII and VWF values are higher in blood donors in India when compared to other populations around the world. 26,27 Although the exact mechanism A variable laboratory phenotype was seen among the OCs.…”

Comparison of Factor Viii Activity in O and Non-O Blood Types

“…Some previous studies have claimed that non-O blood types have the risk of thrombosis and O blood type with the risk of hemorrhage. 4,6,8,[10][11][12] Factor-VIII is an acute phase protein and is increased temporarily during an inflammatory process. Kamphuisen's study showed no relationship between factor VIII activity and CRP (C-Reactive Protein) in venous thrombosis patients.…”