“…Breast cancer detection is currently based on physical examination and imaging (mammography, ultrasound, and MRI) [6], although emerging methods include direct examination of the cytomorphology of exfoliated cells [7], and the molecular analysis of tumor biomarkers in nipple aspirate fluid or in ductal lavage [8], [9], [10]. In the last decade, biomarker discoveries for breast cancer detection have focused on blood and/or tissue, using proteomic [11], [12], [13], [14], [15], [16], transcriptomic [17], [18], [19], [20], [21], and genomic approaches [22], [23]. In comparison to prognostic biomarkers [24], [25], [26], the development of detection biomarkers has been limited, mainly due to a lack of sensitivity and specificity for this clinical context [2], [27], [28].…”