Evaluation of Exosomal miRNA as Potential Biomarkers in Cervical Cancer

Abstract

Different studies show that small non-coding RNAs, such as microRNAs (miRNAs) obtained from exosomes, are considered potential biomarkers in several types of cancer, including cervical cancer (CC). Therefore, the present study seeks to present an overview of the role of circulating exosomal miRNAs with the potential to act as biomarkers for the diagnosis and prognosis of CC and to analyze the presence of these miRNAs according to the stage of CC. For this purpose, a review was developed, with articles consulted from the electronic databases MEDLINE/PubMed, Scopus, and Web of Science published between 2015 and 2021. Seven articles were included after a selection of studies according to the eligibility criteria. In addition to the methods used for sample analysis, detection, and isolation of miRNAs in each article, clinical data were also extracted from the patients studied, such as the stage of cancer. After analyzing the network of the seven miRNAs, they were associated with the immune system, CC progression and staging, and cisplatin resistance. With the belief that studies on miRNAs in cervical cancer would have major clinical implications, in this review, we have attempted to summarize the current situation and potential development prospects.

Advancements in the Management of Cervical Intraepithelial Neoplasia: A Comprehensive Review

“…Circulating microRNAs (miRNAs) have exhibited potential as non-invasive biomarkers for identifying cervical lesions, facilitating early diagnosis and risk assessment [ 27 ]. Exosomal miRNAs like miR-125a-5p, let-7d-3p, and miR-30d-5p have been recognized as diagnostic biomarkers for cervical cancer and its precursors, highlighting their utility in non-invasive screening modalities [ 28 ]. Specific long non-coding RNAs have also been spotlighted as biomarkers for predicting cervical cancer, furnishing insights into disease progression, and identifying potential therapeutic targets [ 28 ].…”

“…Exosomal miRNAs like miR-125a-5p, let-7d-3p, and miR-30d-5p have been recognized as diagnostic biomarkers for cervical cancer and its precursors, highlighting their utility in non-invasive screening modalities [ 28 ]. Specific long non-coding RNAs have also been spotlighted as biomarkers for predicting cervical cancer, furnishing insights into disease progression, and identifying potential therapeutic targets [ 28 ]. These molecular biomarkers furnish clinicians with valuable insights into diagnosing cervical cancer, prognosticating, and guiding treatment decisions.…”

Role of microRNA in Sex Steroid Hormones Signaling and Its Effect in Regulation of Endometrial, Ovarian, and Cervical Cancer: A Literature Review

“…Exosomes are also implicated in various processes related to cancer, including metastasis, angiogenesis, tumor immunity, and treatment resistance. While miRNAs have been established as diagnostic biomarkers for cervical cancer and precancerous lesions, further investigation is needed to understand the role of exosomal cervical cancer-derived miRNAs as diagnostic biomarkers and their contribution to cervical cancer progression [28].…”