Evaluation of ethanol leaf extract of <i>Ocimum sanctum</i> in experimental models of anxiety and depression

Chatterjee, Manavi; Verma, Pinki; Maurya, Rakesh; Palit, Gautam

doi:10.3109/13880209.2010.523832

Cited by 43 publications

(33 citation statements)

References 25 publications

(28 reference statements)

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“…Besides possessing fewer adverse effect, natural products structurally possess broad spectrum chemical diversity, biochemical specificity and other medicinal properties that also make them favourable as lead structures for the remedies of a number of disorders including psychosis [7,8]. Therefore we have directed our endeavours towards establishing the scientific rational in governing the efficacy of one of the much studied and most consumed species of ginseng in United state for its potential to treat schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antipsychotic Potential of Panax quinquefolium in Ketamine Induced Experimental Psychosis Model in Mice

et al. 2011

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The search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has progressed significantly from the past few decades and their therapeutic potential has been assessed in a variety of animal models. The aim of our study was to screen one such plant, Panax quinquefolium (PQ), with significant neuroactive properties for its antipsychotic potential. A graded dose study with PQ at 12.5-200 mg/kg, p. o. showed differential effects against the ketamine induced hyperactivity in the Digiscan animal activity monitor. Nevertheless at 100 mg/kg, p.o., PQ blocked ketamine induced memory impairment in the passive avoidance paradigm. In the chronic studies, PQ reduced the ketamine induced enhanced immobility in the forced swim test and did not show extra-pyramidal side effects in bar test and wood block test of catalepsy. These behavioural effects were compared with standard drugs haloperidol and clozapine. Further PQ reduced DA and 5-HT content after chronic treatment, but not after acute administration. In addition, PQ extract reduced acetylcholinesterase activity and nitrate levels, however increased glutamate levels in hippocampus. Overall our findings suggest that PQ possess antipsychotic like properties, which may leads to future studies with its specific constituents which may particularly be beneficial in predominant negative and cognitive symptoms of schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Antipsychotic Potential of Panax quinquefolium in Ketamine Induced Experimental Psychosis Model in Mice

et al. 2011

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“…Investigations are now focused on the search of novel and better tolerated molecules from natural resources to control the severity and the progression of mental disorders (Chatterjee et al, 2011b(Chatterjee et al, , 2013Ishola et al, 2012;Zhang, 2004). Natural products have characteristically high chemical diversity, biochemical specificity, and several other medicinal properties that make them favorable lead structures for the treatment for various disorders, including psychosis.…”

Section: Introductionmentioning

confidence: 99%

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Chatterjee

Verma

Kumari

et al. 2015

Pharmaceutical Biology

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(2015) Antipsychotic activity of standardized Bacopa extract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems, Pharmaceutical Biology, 53:12, 1850-1860, DOI: 10.3109/13880209.2014 (40, 80, and 120 mg/kg, p.o.) were given to the mice 1 h prior to ketamine administration and tested for positive symptoms and cognitive deficits. A chronic ketamine treatment regimen was used to study the effect of BM on negative symptoms such as immobility enhancement. Each mouse was used once for the behavioral studies.Results: BM reduced ketamine-induced hyperactivity with an EC 50 value of 76.60 mg/kg. The 80 mg/kg dose was used for all other behavior analysis. Pretreatment with BM at 80 mg/kg showed two-fold increases in transfer latency time (TLT) in passive avoidance task. Chronic BM pretreatment (80 mg/kg p.o. daily Â 10 d) ameliorated the ketamine-induced enhanced immobility effect by 21% in the forced swim test. BM treatment reversed ketamine-induced increase in monoamine oxidase activity in both cortex and striatum and normalized the acetylcholinesterase activity and the glutamate levels in the hippocampus. Discussion and conclusion: Overall our findings suggest that BM possesses antipsychotic properties which might be due to its modulatory action on dopamine, serotonin, and glutamate neurotransmission.

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“…The apparatus consists of 2 compartments; a compartment illuminated by light and a second compartment that is covered and is dark, with dimensions (20 × 20 cm). The compartments were connected by an opening 7.5 × 7.5 cm located at fl oor level in the centre of the partition [ 22 ] . 4 groups (n = 8) were pretreated as follows: Group I -0.5 % gum acacia in normal saline (…”

Section: Light/dark Testmentioning

confidence: 99%

“…The hole-board test provides a simple method for measuring the response of an animal to an unfamiliar environment and is widely used to assess emotionality, anxiety, and/or responses to stress in animals [ 37 ] . Head-dipping behavior [ 38 ] is sensitive to changes in the emotional state of the animal, and has been suggested to express an anxiolytic state in animals, which may be refl ected by an increase in head-dipping behavior [ 22 ] . Our results showed that C. thonningii increased the number of head-dips, indicating anxiolytic-like eff ect.…”

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confidence: 99%

Antidepressant and Anxiolytic Effects of the Methanol Root Extract of Capparis thonningii: Involvement of Monoaminergic, Cholinergic and GABAergic Systems

et al. 2014

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Evaluation of ethanol leaf extract of Ocimum sanctum in experimental models of anxiety and depression

Cited by 43 publications

References 25 publications

Evaluation of the Antipsychotic Potential of Panax quinquefolium in Ketamine Induced Experimental Psychosis Model in Mice

Evaluation of the Antipsychotic Potential of Panax quinquefolium in Ketamine Induced Experimental Psychosis Model in Mice

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Antidepressant and Anxiolytic Effects of the Methanol Root Extract of Capparis thonningii: Involvement of Monoaminergic, Cholinergic and GABAergic Systems

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