Evaluation of Erythropoietin Levels in the Anemia of Thermal Injury

Vasko, Susan D.; Burdge, Jeremy J.; Ruberg, R.L.; Verghese, Alexia S.

doi:10.1097/00004630-199109000-00008

Cited by 22 publications

(15 citation statements)

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“…Most studies have defined the transfusion trends in burn patients, focusing on the relationship between % TBSA burn and transfusion needs [12–14]. …”

Section: Introductionmentioning

confidence: 99%

“…Graves et al patients with >10% TBSA burn received an average of 19.7 units of blood [13],while for Vasko et al, their patients with >10% TBSA burn required an average of 8.94 units per patient [14]. However this conclusion overly generalizes patients as >10% could mean 11, 25, 70%.…”

Section: Introductionmentioning

confidence: 99%

“…However this conclusion overly generalizes patients as >10% could mean 11, 25, 70%. For patients with >30% TBSA, the mean transfusion requirement was 17 units [14]. Palmieri et al found that, on average, 13.7 ± 1.1 units of PRBCs were transfused per patient with >20% TBSA, for burns of >50% TBSA, 30 units of blood were transfused per patient [12].…”

Section: Introductionmentioning

confidence: 99%

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Determinants and time to blood transfusion among thermal burn patients admitted to Mulago Hospital

2017

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BackgroundBlood transfusion, a practice under re-evaluation in general, remains common among thermal burn patients due to the hematological alterations associated with burns that manifest as anemia. Today advocacy is for restrictive blood transfusion taking into account individual patient characteristics. We went out to identify the parameters that may determine transfusion requirement and the time to blood transfusion for thermal burn patients in Mulago Hospital in order to build statistics and a basis to standardize future practice and Hospital protocol.Methods112 patients with thermal burns were enrolled into a prospective cohort study conducted in the Surgical Unit of the Accidents and Emergency Department and Burns Unit of Mulago Hospital. Relevant data on pre-injury, injury and post-injury factors was collected including relevant laboratory investigations and treatment modalities like surgical intervention. Patients were clinically followed up for a maximum period of 28 days and we identified those that were transfused.Results22.3% of patients were transfused. The median time to transfusion was 17 days from time of injury and varied with different patient characteristics. The median pre-transfusion hemoglobin (Hb) level was 8.2 g/dL. Transfusion was significantly related to; admission to the intensive care unit (p = 0.001), a body mass index (BMI) <2 kg/m2 (p = 0.021), % total burn surface area (TBSA) >20 (p = 0.049), pre-existing illness (p = 0.046), and white blood cell (WBC) count <4000 or >12,000/μL (p = 0.05).ConclusionPre-existing illnesses, a low BMI, TBSA of >20%, admission to the intensive care unit and abnormalities in the WBC count are useful predictors of blood transfusion among thermal burns patients admitted to Mulago Hospital. The precise time to transfusion from time of burns injury cannot be generalized. With close monitoring of each individual patient lies the appropriateness and timeliness of their management.

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“…Most studies have defined the transfusion trends in burn patients, focusing on the relationship between % TBSA burn and transfusion needs [12–14]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Determinants and time to blood transfusion among thermal burn patients admitted to Mulago Hospital

2017

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“…For patients with >30% TBSA, the mean transfusion requirement was 17 units. 7 Palmieri et al found that, on average, 13.7 ± 1.1 units of pRBCs were transfused per patient with ≥20% TBSA. For burns of ≥50% TBSA, >30 units of blood were transfused per patient.…”

Section: Transfusion Ratesmentioning

confidence: 99%

“…However, a reticulocytopenic anemia persisted despite this increase in EPO. 7 Deitch and Sittig measured EPO, serum iron, total iron binding capacity, ferritin, transferrin saturation, hemoglobin, and reticulocyte counts in 24 burn patients and stratified them based on burn size. There was an inverse correlation between hemoglobin and EPO, indicating an appropriate response to anemia.…”

Section: Reducing Transfusion: Epo Surgical Techniques and Transfusmentioning

confidence: 99%

Anemia of Thermal Injury: Combined Acute Blood Loss Anemia and Anemia of Critical Illness

Posluszny

Gamelli

2010

Journal of Burn Care & Research

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Blood Transfusions for Burn Patients

Tariq

Hoffman

et al. 2021

Essentials of Blood Product Management in Anesthesia Practice

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Evaluation of Erythropoietin Levels in the Anemia of Thermal Injury

Cited by 22 publications

References 0 publications

Determinants and time to blood transfusion among thermal burn patients admitted to Mulago Hospital

Determinants and time to blood transfusion among thermal burn patients admitted to Mulago Hospital

Anemia of Thermal Injury: Combined Acute Blood Loss Anemia and Anemia of Critical Illness

Blood Transfusions for Burn Patients

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