Evaluation of erythrocyte and reticulocyte parameters as indicative of iron deficiency in patients with anemia of chronic disease

Torino, Ana Beatriz Barbosa; Gilberti, Maria de Fátima Pererira; Costa, Edvilson da; Lima, Gisélia Aparecida Freire de; Grotto, Helena Zerlotti Wolf

doi:10.1016/j.bjhh.2015.02.004

Cited by 24 publications

(32 citation statements)

References 22 publications

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“…Mean serum ferritin levels in the three groups were 10.85, 83.35 and 773.4 µg/L, respectively, while median values were 10.9, 63.4 and 374 µg/L, respectively. Similar results were seen in studies by Torino et al and Punnonen et al As serum ferritin is a marker of inflammation, the levels tend to be higher in patients suffering from inflammatory disorders and therefore it cannot be relied upon as a sole marker for iron status in these subset of patients.…”

Section: Discussionmentioning

confidence: 99%

“…The mean levels of Ret He in the three groups were 20.82, 25.26 and 28.1 pg, while the median values were 21, 25.1 and 27.9 pg in the three groups, respectively. In study by Torino et al the median Ret He in the control group was 35.1 pg as compared to ACD/ACD combined/IDA where the values were 29.7/26/25.2, respectively. The values in our study were consistent with the previously published results.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of reticulocyte hemoglobin for assessment of anemia in rheumatological disorders

et al. 2019

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Objective: The aim of this study was to evaluate the role of reticulocyte hemoglobin (Ret He) estimation in subtyping of anemia and to find the correlation of Ret He with the severity of anemia. Methods:Ninety-four patients with rheumatic diseases with anemia were enrolled.Blood samples were taken to determine various parameters. Patients were divided into three groups: iron deficiency anemia, anemia of chronic disease with iron deficiency and anemia of chronic disease depending on the iron status and inflammatory markers. Analysis of variance and Pearson correlation coefficient were used. Receiver operating characteristic analysis was used to evaluate the accuracy of the parameters in differentiating anemia. Results: Statistically significant differences among groups were seen with regard to parameters such as erythrocyte sedimentation rate, C-reactive protein, serum ferritin, total iron binding capacity, transferrin saturation, transferrin receptor protein, soluble transferrin receptor/log ferritin and Ret He. Ret He correlates with the subtype of anemia in patients with rheumatic disorders but it does not correlate with the severity of anemia. Soluble transferrin receptor/log ferritin, Ret He and serum ferritin values were the best parameters to differentiate between various groups. Ret He (pg) values of <24, 24-26.5 and >26.5, while serum ferritin levels (µg/L) of <35, 35-178 and >178 were highly sensitive and specific for iron deficiency anemia, anemia of chronic disease with iron deficiency and anemia of chronic disease groups, respectively. Conclusion: In cost constraints settings, a simple investigation like Ret He alone or with serum ferritin can help us to diagnose and differentiate between the different types of anemia accompanying rheumatological disorders without doing other serum iron studies and expensive tests like transferrin receptor protein which are not readily available. K E Y W O R D S assessment of anemia, log ferritin, Ret He, soluble transferrin receptor

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of reticulocyte hemoglobin for assessment of anemia in rheumatological disorders

et al. 2019

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“…Dentro deste contexto, os parâmetros reticulocitários se apresentam como uma boa alternativa para o diagnóstico da DF. Como os reticulócitos tem uma sobrevida de 1 a 2 dias no sangue periférico, eles fornecem informações que correspondem ao conteúdo de hemoglobina em eritrócitos recém-formadas, sendo, portanto, um indicador precoce da bioviabilidade do ferro (TORINO et al, 2015).…”

Section: Deficiência De Ferrounclassified

“…O IRF equivale aos reticulócitos que possuem média e alta fluorescência, sendo determinados pelos equipamentos que utilizam as metodologias de dispersão a laser, correspondendo a soma de MRF e de HRF. A determinação das frações de imaturidade reticulócitos (LFR, MFR e HFR) e a fração de reticulócitos imaturos (IRF), têm sido estudadas como parâmetros úteis para avaliação precoce de recuperação medular após transplantes de medula óssea (GROTTO et al, 1999;SCHILLER;MORAN, 2006;TORINO et al, 2015). O aumento da porcentagem de reticulócitos imaturos pode predizer a recuperação de tratamento de anemias aplásticas ou a recuperação de tratamento quimioterápicos, antes mesmo da elevação da contagem absoluta de reticulócitos, de neutrófilos e de plaquetas (WATANABE et al, 1994;GROTTO et al, 1999;GONCALO et al, 2011;DA SILVA et al, 2016).…”

Section: 32 Reticulócitos Imaturos E As Frações De Imaturidade Dounclassified

Reticulocyte Hemoglobin Content in the Diagnosis of Iron Deficiency

Monteiro¹,

Carvalho

Comeron

et al. 2016

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Introdução: A contagem de reticulócitos no sangue periférico fornece informações sobre a atividade eritropoiética, a qual só pode ser mantida pela disponibilidade suficiente de ferro à medula óssea para produção de hemoglobina. A quantidade de hemoglobina contida nos reticulócitos pode servir de indicador da eritropoiese, sendo utilizada para o diagnóstico e monitoramento de pacientes com anemias por deficiência de ferro. Objetivos: O presente trabalho tem como objetivo pesquisar a aplicabilidade do conteúdo de hemoglobina do reticulócitos, liberado pelos analisadores hematológicos, como parâmetro no diagnóstico da deficiência de ferro. Metodologia: O estudo consiste em um levantamento bibliográfico de livros e artigos científicos das bases de dados MEDLINE Pubmed, SciELO e BIREME relacionado ao conteúdo de hemoglobina no reticulócito e sua aplicação no diagnóstico da deficiência de ferro. Resultados e Discussão: Em geral, não existe um teste laboratorial utilizado na rotina, com sensibilidade e especificidade suficiente para ser de forma isolada, o marcador definitivo da deficiência de ferro. Entre os índices reticulocitários utilizados na prática clínica, o conteúdo de hemoglobina dos reticulócitos tem sido amplamente investigado para o diagnóstico da depleção de ferro, sendo útil na identificação de estados iniciais de anemia por deficiência deste metal, antecipando tratamentos com ferro e impedindo a implantação da anemia em estágios mais avançados. Além disto, o conteúdo de hemoglobina do reticulócitos também pode ser útil para identificar pacientes que não respondem ao tratamento com ferro via oral, no qual o conteúdo de hemoglobina nos reticulócitos permanece baixo, mesmo após o início da terapia. Conclusão: Apesar de existirem limitações relacionadas a padronização dos valores de normalidade do conteúdo de hemoglobina do reticulócitos, a análise deste índice reticulocitário parece ter um futuro promissor como um parâmetro de grande aplicabilidade para avaliação dos estados de deficiência de ferro.

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“…Several alternative markers have been proposed in recent years, of which reticulocyte hemoglobin content (CHr) and percentage of hypochromic red blood cells (%Hypo) are the most promising [8][9][10][11]. The reticulocytes last only 24 to 48 h in circulation before developing into mature red blood cells.…”

Section: Introductionmentioning

confidence: 99%

The validity of reticulocyte hemoglobin content and percentage of hypochromic red blood cells for screening iron-deficiency anemia among patients with end-stage renal disease: a retrospective analysis

2020

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Background: Early detection of iron-deficiency anemia (IDA) can enhance the efficiency and effectiveness of clinical treatment and quality of life for end-stage renal disease (ESRD) patients. This study aimed to evaluate the validity of CHr and %Hypo in screening IDA among ESRD patients and compare their performance with screening IDA among non-ESRD patients. Method: A retrospective analysis of 312 participants was conducted at Cho Ray Hospital, Vietnam, including healthy control participants and ESRD patients. Receiver operator characteristics curves and the area under the curve (AUC) of models were used to evaluate the performance of CHr, %Hypo. Optimal cutoff values were determined using Youden's index. Results: Detecting IDA in ESRD patients is more complicated, as the screening performance of CHr and %Hypo in predicting IDA among ESRD patients were lower than non ESRD group, but still reasonable with AUC = 0.748 (95% CI: 0.656-0.840, power = 0.997) and 0.740 (95% CI: 0.647-0.833, power = 0.996), respectively. Cutoff values of CHr < 31.5 pg and %Hypo> 10.0 pg are recommended to obtain optimal screening ability for Vietnamese ESRD patients. Conclusion: CHr and %Hypo appears to be useful tools for screening IDA among both non ESRD and ESRD patients. The low cost and accessible of the two markers encourage their utility as effective screening tools in clinical practice.

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Evaluation of erythrocyte and reticulocyte parameters as indicative of iron deficiency in patients with anemia of chronic disease

Cited by 24 publications

References 22 publications

Evaluation of reticulocyte hemoglobin for assessment of anemia in rheumatological disorders

Evaluation of reticulocyte hemoglobin for assessment of anemia in rheumatological disorders

Reticulocyte Hemoglobin Content in the Diagnosis of Iron Deficiency

The validity of reticulocyte hemoglobin content and percentage of hypochromic red blood cells for screening iron-deficiency anemia among patients with end-stage renal disease: a retrospective analysis

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