Evaluation of Epstein-Barr virus-specific antibodies in Cypriot multiple sclerosis patients

Deeba, Elie; Koptides, Dana; Gaglia, Efthychia; Constantinou, Astero; Lambrianides, Anastasia; Pantzaris, Marios; Krashias, George; Christodoulou, Christina

doi:10.1016/j.molimm.2018.12.010

Cited by 22 publications

(9 citation statements)

References 62 publications

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“…MS does not develop in the absence of exposure to EBV, and EBV is a 'required', but insufficient on its own, contributor in early disease pathophysiology. Independent support comes from an observed higher rate of EBV activation in MS [22,23], a role for EBV in triggering new relapses consistent with a reduced ability of EBV-specific CD8 + T cells (e.g., T cell exhaustion, see Glossary) to limit EBV reactivation in MS patients [24,25], and a strong correlation between the presence of anti-EBV antibodies in blood and disease onset [26][27][28][29]. Evidence of CNS involvement comes from reports of elevated anti-EBNA1 IgG serology associated with the appearance of new gadolinium (Gd)enhancing brain lesions [30] and the presence, in patients, of EBNA1-specific T cells recognizing myelin [31].…”

Section: Multiple Sclerosis and Ebv: Evolution Of The Theorymentioning

confidence: 93%

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

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Pender

Khanna

et al. 2020

Trends in Molecular Medicine

199

149

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New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere of excitement in the MS community. B cells are now known to play a major role in disease, demonstrated by the highly impactful effect of a B cell-depleting antibody on controlling MS. The idea that a virus may play a role in the development of MS has a long history and is supported mostly by studies demonstrating a link between B cell-tropic Epstein-Barr virus (EBV) and disease onset. Efforts to develop antiviral strategies for treating MS are underway. Although gaps remain in our understanding of the etiology of MS, the role, if any, of viruses in propagating pathogenic immune responses deserves attention. HighlightsClinical studies show that depletion of B cells reduces disease burden in both relapsing-remitting and progressive multiple sclerosis (MS) patients.

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Section: Multiple Sclerosis and Ebv: Evolution Of The Theorymentioning

confidence: 93%

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

Bar‐Or

Pender

Khanna

et al. 2020

Trends in Molecular Medicine

199

149

View full text Add to dashboard Cite

show abstract

“…12 For the purpose of statistical analysis, z -scores were calculated for 9-HPT and TWT from normative values displayed in the National Multiple Sclerosis Society Task Force database. 13…”

Section: Methodsmentioning

confidence: 99%

“…12 For the purpose of statistical analysis, z-scores were calculated for 9-HPT and TWT from normative values displayed in the National Multiple Sclerosis Society Task Force database. 13 Other clinical measures, which can reflect spinal cord pathology, were tested including the following: American Spinal Injury Association (ASIA) motor and sensory scale, 14 Multiple Sclerosis Walking Scale-12 (MSWS-12) 15 and Modified Ashworth Scale (MAS), 16 grip strength from upper limbs (Sammons Preston, Incorporated, Bolingbrook, IL, USA), vibration perception thresholds (VPTs), (Bio -medical Instrument Company, Newbury, Ohio) and postural stability. 17…”

Section: Clinical Assessmentsmentioning

confidence: 99%

Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis

et al. 2020

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Background: Pathology in the spinal cord of patients with primary progressive multiple sclerosis (PPMS) contributes to disability progression. We previously reported abnormal Q-space imaging (QSI)-derived indices in the spinal cord at baseline in patients with early PPMS, suggesting early neurodegeneration. Objective: The aim was to investigate whether changes in spinal cord QSI over 3 years in the same cohort are associated with disability progression and if baseline QSI metrics predict clinical outcome. Methods: Twenty-three PPMS patients and 23 healthy controls recruited at baseline were invited for follow-up cervical cord 3T magnetic resonance imaging (MRI) and clinical assessment after 1 year and 3 years. Cord cross-sectional area (CSA) and QSI measures were obtained, together with standard brain MRI measures. Mixed-effect models assessed MRI changes over time and their association with clinical changes. Linear regression identified baseline MRI indices associated with disability at 3 years. Results: Over time, patients deteriorated clinically and showed an increase in cord QSI indices of perpendicular diffusivity that was associated with disability worsening, independently of the decrease in CSA. Higher perpendicular diffusivity and lower CSA at baseline predicted worse disability at 3 years. Conclusion: Increasing spinal cord perpendicular diffusivity may indicate ongoing neurodegeneration, which underpins disability progression in PPMS, independently of the development of spinal cord atrophy.

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“…EBV infection in MS is documented in several articles. [69][70][71][72][73][74][75][76][77] Hassani et al have shown the presence of EBV in 90% of the tested MS cases (n = 101) compared with that in only 24% of the non-MS control cases (n = 24). EBV infection is associated with B cells, CD8 + T cells, astrocytes, and microglia.…”

Section: Mohammedmentioning

confidence: 99%

Environmental Influencers, MicroRNA, and Multiple Sclerosis

Mohammed

2020

J Cent Nerv Syst Dis

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Multiple sclerosis (MS) is a complex neurological disorder characterized by an aberrant immune system that affects patients’ quality of life. Several environmental factors have previously been proposed to associate with MS pathophysiology, including vitamin D deficiency, Epstein-Barr virus (EBV) infection, and cigarette smoking. These factors may influence cellular molecularity, interfering with cellular proliferation, differentiation, and apoptosis. This review argues that small noncoding RNA named microRNA (miRNA) influences these factors’ mode of action. Dysregulation in the miRNAs network may deeply impact cellular hemostasis, thereby possibly resulting in MS pathogenicity. This article represents a literature review and an author’s theory of how environmental factors may induce dysregulations in the miRNAs network, which could ultimately affect MS pathogenicity.

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Evaluation of Epstein-Barr virus-specific antibodies in Cypriot multiple sclerosis patients

Cited by 22 publications

References 62 publications

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

Ongoing microstructural changes in the cervical cord underpin disability progression in early primary progressive multiple sclerosis

Environmental Influencers, MicroRNA, and Multiple Sclerosis

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