Evaluation of epidural administration of morphine or morphine and bupivacaine for postoperative analgesia after premedication with an opioid analgesic and orthopedic surgery in dogs

Kona‐Boun, Jean‐Jacques; Cuvelliez, Sophie; Troncy, Éric

doi:10.2460/javma.229.7.1103

Cited by 85 publications

(80 citation statements)

References 36 publications

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“…[5][6][7][8][9][10] Multimodal treatment, defined as the simultaneous use of different techniques or drugs, has been recommended because of its ability to act via various mechanisms, which results in additive or synergistic effects. [11][12][13] In 1 study, 14 investigators found that administration of a single drug is often not sufficient for controlling postoperative pain.…”

mentioning

confidence: 99%

“…The combination of different techniques, such as administration of systemically active drugs (opioids, NSAIDs, and local anesthetics), use of regional analgesia (epidural and intra-articular analgesia), and physical methods (compression, cryotherapy, and immobilization), results in balanced analgesia and better pain control. 5,7,10,11,13 A combination of perioperative administration of NSAIDs, incisional and intra-articular analgesia, and postoperative cryotherapy has been successfully used for patients undergoing CrCL repair.…”

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confidence: 99%

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Effect of cold compression therapy on postoperative pain, swelling, range of motion, and lameness after tibial plateau leveling osteotomy in dogs

Drygas¹,

McClure²,

Goring³

et al. 2011

javma

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Objective—To evaluate the effect of cold compression therapy (CCT) on postoperative pain, lameness, range of motion of the stifle joint, and swelling following tibial plateau leveling osteotomy (TPLO) in dogs. Design—Randomized, blinded, placebo-controlled clinical trial. Animals—34 client-owned dogs with unilateral deficiency of a cranial cruciate ligament undergoing TPLO. Procedures—Dogs were assigned to 2 groups. Group 1 (n = 17 dogs) received CCT in the 24-hour period following TPLO. Group 2 (n = 17 dogs) received no CCT. Degree of lameness, range of motion, and circumference of the stifle joint were measured before surgery and 1,14, and 28 days after surgery. A modified composite Glasgow pain scale, visual analogue scale, and pain threshold score were used to evaluate signs of pain before surgery and 1,14, and 28 days after surgery. Logistic regression and linear regression analysis were used to compare the measured variables. Results—No complications were observed, and all dogs tolerated CCT. Use of CCT resulted in lower values for the visual analogue scale and Glasgow pain scale and lower pain threshold scores; lower lameness scores; less swelling; and an increased range of motion 24 hours after surgery. At 14 days after surgery, there were no significant differences between groups. At 28 days after surgery, too few data sets were available for comparison. Conclusions and Clinical Relevance—CCT decreased signs of pain, swelling, and lameness and increased stifle joint range of motion in dogs during the first 24 hours after TPLO.

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confidence: 99%

mentioning

confidence: 99%

Effect of cold compression therapy on postoperative pain, swelling, range of motion, and lameness after tibial plateau leveling osteotomy in dogs

Drygas¹,

McClure²,

Goring³

et al. 2011

javma

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“…Several studies have reported the high analgesic efficacy and long duration of action of ED morphine 2,5,19,20 . Nevertheless, a few published studies have described the analgesic properties and the efficacy of extradural tramadol in dogs 10,17 .…”

Section: Discussionmentioning

confidence: 99%

A comparison of extradural tramadol and extradural morphine for postoperative analgesia in female dogs undergoing ovariohysterectomy

et al. 2012

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PURPOSE: To compare the postoperative analgesic effects of the extradural tramadol or morphine in female dogs undergoing ovariohysterectomy. METHODS: Sixteen female dogs were randomly assigned to two groups of eight animals each and received morphine (0.1mg kg-1 M group) or tramadol (2mg kg-1 T group). The pre-anesthetic medication was intravenously (iv) acepromazine (0.05mg kg-1). Anesthesia was induced with propofol (4mg kg-1iv) and maintained with isoflurane. The degree of analgesia was evaluated using a numerical rating scale that included physiologic and behavior variables. Dogs were scored at one, three, six and 12 hours after surgery by one blinded observer. Dogs were treated with morphine (0.5mg kg-1) if their scores were >6. Serum cortisol was measured before the pre-anesthetic medication was administered (basal), at the time of the ovarian pedicle clamping (T0), and at 1 (T1), 6 (T6) and 12 (T12) hours postoperative. RESULTS: The pain score did not differ between morphine and tramadol treatments. Rescue analgesia was administered to one dog in the T treatment group. Serum cortisol did not differ between treatments. CONCLUSION: The extradural administration of morphine or tramadol is a safe and effective method of inducing analgesia in female dogs undergoing ovariohyterectomy.

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“…The pain was measured before the sedation (baseline scores), and at 30 min, and 1, 2, 4, 6, 8, 12, 20 and 24 hours after extubation, using the Glasgow Composite Pain Scale (GCPS) 3,23 . Next, pain was assessed using a Visual Analogue Scale (VAS) in which, 0=no pain and 100=worst possible pain, manifested by vocalization, aggression, and refusal to allow the examination) [1][2][3][4][5] .…”

Section: This Study Was Approved By the Institutional Animalmentioning

confidence: 99%

“…Orthopedic surgery in dogs is commonly associated with moderate to severe postoperative pain and inflammation [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Analgesic comparison of systemic lidocaine, morphine or lidocaine plus morphine infusion in dogs undergoing fracture repair

et al. 2014

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Intellectual and scientific content of the study, statistical analysis, critical revision. ABSTRACT PURPOSE:To compare the postoperative analgesic effects of lidocaine, morphine and lidocaine plus morphine administered by constant rate infusion (CRI) and analyzing their effects on opioid requirements after orthopedic surgery in dogs. METHODS:Twenty-four dogs underwent fracture repairs were premedicated with IM acepromazine (0.05 mg/kg) combined with morphine (0.3mg/kg). Anesthesia was induced with IV propofol (4 to 5 mg/ kg) and maintained with isoflurane. The dogs were randomly assigned to 3 groups and administered a CRI IV of lidocaine (T-L), morphine (T-M) or lidocaine plus morphine (T-LM) at the same doses. Postoperative analgesia was assessed for 24 hours using a Visual Analog Scale (VAS) and the Glasgow Composite Pain Scale (GCPS). Rescue analgesia was performed if the evaluation score exceeded 50% of the VAS and/or 33% of the GCPS. RESULTS:The pain score and postoperative opioid requirements did not differ among the treatments. Rescue analgesia was administered to 1/8 dogs in the T-M and T-LM, and to 3/8 dogs in the T-L. CONCLUSION:Lidocaine, morphine or lidocaine/morphine CRI may be efficacious techniques for pain management in the first 24 hours post-surgery. However, the two drugs administered together did not reduce the postoperative opioid requirement in dogs undergoing fracture repair.

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Evaluation of epidural administration of morphine or morphine and bupivacaine for postoperative analgesia after premedication with an opioid analgesic and orthopedic surgery in dogs

Cited by 85 publications

References 36 publications

Effect of cold compression therapy on postoperative pain, swelling, range of motion, and lameness after tibial plateau leveling osteotomy in dogs

Effect of cold compression therapy on postoperative pain, swelling, range of motion, and lameness after tibial plateau leveling osteotomy in dogs

A comparison of extradural tramadol and extradural morphine for postoperative analgesia in female dogs undergoing ovariohysterectomy

Analgesic comparison of systemic lidocaine, morphine or lidocaine plus morphine infusion in dogs undergoing fracture repair

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