Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-<sup>13</sup>C]glycine and its deuteration toward longer retention of the hyperpolarized state

Kondo, Yohei; Saito, Yutaro; Elhelaly, Abdelazim Elsayed; Hyodo, Fuminori; Nishihara, Tatsuya; Itoda, Marino; Nonaka, Hiroshi; Sando, Shinsuke

doi:10.1039/d1ra07343e

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Cited by 4 publications

References 26 publications

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Hyperpolarized tracer design, synthesis, and characterization

Suh,

Eskandari,

Huynh

et al. 2024

Advances in Magnetic Resonance Technology and Applications

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Hyperpolarized tracer design, synthesis, and characterization

Suh,

Eskandari,

Huynh

et al. 2024

Advances in Magnetic Resonance Technology and Applications

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Enzyme-activated nanomaterials for MR imaging and tumor therapy

Lv,

Yue,

Liu

et al. 2024

Coordination Chemistry Reviews

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Detecting biomarkers by dynamic nuclear polarization enhanced magnetic resonance

Chen,

Zhang,

et al. 2024

National Science Review

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Hyperpolarization stands out as a technique capable of significantly enhancing the sensitivity of nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Dynamic nuclear polarization (DNP), among various hyperpolarization methods, has gained prominence for its efficacy in real-time monitoring of metabolism and physiology. By administering a hyperpolarized substrate through dissolution DNP (dDNP), the biodistribution and metabolic changes of the DNP agent can be visualized spatiotemporally. This approach proves to be a distinctive and invaluable tool for non-invasively studying cellular metabolism in vivo, particularly in animal models. Biomarker plays a pivotal role in influencing the growth and metastasis of tumor cells by closely interacting with them, and accordingly detecting pathological alterations of these biomarkers is crucial for disease diagnosis and therapy. In recent years, a range of hyperpolarized DNP molecular bioresponsive agents utilizing various nuclei, such as 13C, 15N, 31P, 89Y, etc., have been developed. In this context, we explore how these magnetic resonance signals of nuclear spins enhanced by DNP respond to biomarkers, including pH, metal ions, enzymes, or redox processes. This review aims to offer insights into the design principles of responsive DNP agents, target selection, and the mechanisms of action for imaging. Such discussions aim to propel the future development and application of DNP-based biomedical imaging agents.

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Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-¹³C]glycine and its deuteration toward longer retention of the hyperpolarized state

Abstract: By examining enzymatic and magnetic properties, γ-Glu-[1-13C]Gly-d2 was developed as a long-lived DNP molecular probe for detecting γ-glutamyl transpeptidase.

Cited by 4 publications

References 26 publications

Hyperpolarized tracer design, synthesis, and characterization

Hyperpolarized tracer design, synthesis, and characterization

Enzyme-activated nanomaterials for MR imaging and tumor therapy

Detecting biomarkers by dynamic nuclear polarization enhanced magnetic resonance

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Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-13C]glycine and its deuteration toward longer retention of the hyperpolarized state

Abstract: By examining enzymatic and magnetic properties, γ-Glu-[1-13C]Gly-d2 was developed as a long-lived DNP molecular probe for detecting γ-glutamyl transpeptidase.

Cited by 4 publications

References 26 publications

Hyperpolarized tracer design, synthesis, and characterization

Hyperpolarized tracer design, synthesis, and characterization

Enzyme-activated nanomaterials for MR imaging and tumor therapy

Detecting biomarkers by dynamic nuclear polarization enhanced magnetic resonance

Contact Info

Product

Resources

About

Evaluation of enzymatic and magnetic properties of γ-glutamyl-[1-¹³C]glycine and its deuteration toward longer retention of the hyperpolarized state